Diagnostic accuracy of fine‐needle aspiration cytology in Warthin tumors

Veder, L.L.; Kerrebijn, Jeroen D. F.; Smedts, Frank; Bakker, Michael A. den

doi:10.1002/hed.21382

Cited by 46 publications

(48 citation statements)

References 32 publications

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“…On the other hand, Patient 2 lacked a lymphoid stroma in the FNAC specimen and showed papillary shaped groups of tumor cells with enlarged nuclei. Although high diagnostic accuracy is commonly reported for WT by FNAC (Veder et al 2010), our observations indicate that FNAC alone may not yield a definitive diagnosis of WT and other salivary gland tumors. Imaging diagnosis without dynamic MRIs showed no effective findings for either of the patients described here.…”

Section: Discussioncontrasting

confidence: 59%

Correct Diagnosis of Warthin Tumor in the Parotid Gland with Dynamic MRI

Ogawa

Suzuki

Sakamoto

et al. 2012

Tohoku J. Exp. Med.

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Warthin tumor (WT) is a benign tumor of the salivary gland primarily affecting middle-aged men. WT is almost exclusively located in the parotid gland and tend to grow slowly without symptoms. Although fine needle aspiration cytology (FNAC) often correctly diagnoses these tumors, they are occasionally misdiagnosed as malignant. Our study sought to distinguish between WT and non-WT using dynamic MRI. In dynamic MRI, a series of images are taken over time measuring the intensity of gadolinium uptake by the parotid. We examined two patients for this study. The first was a 53-year old male, heavy smoker, experiencing manic-depressive episodes. He received a brain MRI at which time his parotid tumor was discovered. Parotid FNAC indicated a squamous cell carcinoma. The second patient was a 76-year old male, moderate smoker and drinker, who had been complaining about swelling in the neck. FNAC of the parotid indicated acinic cell carcinoma and gadolinium-enhanced MRI suggested the tumor was malignant. Prior to surgically extracting of these masses, we performed dynamic MRI on each patient. Both tumors exhibited a pattern consisting of rapid enhancement and rapid attenuation, the pattern of which is characteristic of WT. The surgical specimens confirmed that both were WTs without malignant transformation. Our findings indicate that dynamic MRI is a useful tool for preoperative diagnosis of WT, where other examinations indicate malignancy. Early and correct diagnosis of WT can minimize the use of invasive procedures, and eliminate the stress placed on the patient from a diagnosis of cancer.

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Section: Discussioncontrasting

confidence: 59%

Correct Diagnosis of Warthin Tumor in the Parotid Gland with Dynamic MRI

Ogawa

Suzuki

Sakamoto

et al. 2012

Tohoku J. Exp. Med.

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“…Mucinous metaplasia. The fluid imparts a dirty background appearance that may be confused tumor necrosis [8,10,15] .…”

Section: Discussionmentioning

confidence: 99%

“…Histologi cally, WT characteristically consists of cystic and solid areas. The cystic area is lined by layers of tall columnar on cocytic luminal cells and flattened or cuboidal basal cells, while the stroma consists of lymphocytes [10][11][12] .The cytological diagnosis of cystic salivary gland lesions is rather difficult due to the wide range of lesions that enter the differential diagnosis which include chronic sialadenitis, WT, acinic cell carcinoma, pleomorphic adenoma and mucoepidermoid carcinoma [4,21] .…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Accuracy and Pitfalls in Fine Needle Aspiration Cytology Of Salivary Gland Lesions.

Saldanha

Fernandes²,

Fazalbhoy³

et al. 2017

APALM

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Background: Fine Needle Aspiration cytology (FNAC) is an essential diagnostic method used to evaluate salivary gland lesions. However, at times, diverse morphological patterns and overlapping features between benign and malignant lesions becomes challenging and difficult to give a definitive diagnosis.Aim are to compare the findings of preoperative FNAC with their histopathological types and to discuss the causes for discordancy and identify the potential pitfalls in cytological diagnosis. Materials and Methods:An observational analytical study was carried out over a 4 year period to review the cases of patients with salivary gland lesions who underwent FNAC in a medical college, hospital. Taking histopathological diagnosis as gold standard, the cytological diagnosis of the cases was compared and the causes of discrepancies were evaluated. Sensitivity, specificity, accuracy, positive predictive value and negative predictive value was calculated. Results:In the present study, out of 137 cases, cyto-histological correlation was available in 46 cases. Pleomorphic adenoma was the commonest lesion in the study. The diagnostic value of FNAC was: Sensitivity 66.7%, Specificity 97.4%, Positive Predictive Value 80%, Negative Predictive Value 95% and Diagnostic Accuracy 93.3%. False positive diagnosis was rendered in warthin's tumor whereas false negative diagnosis was given in mucoepidermoid carcinoma. Conclusion:FNAC is useful in the preoperative diagnosis of salivary gland lesions. Pitfalls in cytologic diagnosis were due to errors in sampling, cystic lesions and interpretation of smears .

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“…In our study, two cases were available for histopathological correlation with 100% concordance. [13] Myoepithelioma (myoepithelial adenoma) may be plasmacytoid, epitheloid or spindle cell type.The cellular pleomorphic adenoma may not be distinguisable from myoepithelioma where selective sampling of solid focus of plasmacytoid cells without specific stroma has been done. In our study, four cases were given differential diagnosis of Pleomorphic Adenoma/Myoepithelioma turned out to be Pleomorphic Adenoma in histology.…”

Section: Discussionmentioning

confidence: 99%

Cytological and Histomorphological Correlation of Salivary Gland Lesions- An Experience at Rural Tertiary Healthcare Hospital

Thangam

Kotasthane

et al. 2017

APALM

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Background: Salivary gland tumours account for 3-10% of all the head and neck neoplasm. FNAC is being increasingly used in the diagnosis of salivary gland tumours. The objective of this study was to evaluate the age, sex and site distribution and to evaluate the diagnostic accuracy of fine needle aspiration cytology (FNAC) in various salivary gland lesions in correlation with their histopathology, which helps in appropriate management of the patient. Methods:The present study was done at the pathology department, Mahatma Gandhi Medical College and Research Institute, Pondicherry. FNAC was done using 22 gauge needle and 10 ml syringe and smears were stained with H&E and Giemsa stains. Histopathology was assessed on routine H&E stained paraffin sections .Cyto-histo correlation was done and overall diagnostic accuracy, sensitivity and specificity were calculated. Results:The study was conducted on 122 patients having salivary gland lesions .The age ranged from 24-80 years. Benign tumours were common in 3rd decade, whereas malignant tumours in 6th decade of life. There was female preponderance with male to female ratio of 1:1.03.Parotid glands were commonly involved in 74(78.72%).Out of 94 neoplastic cases,78(82.97%)were benign and 14(14.89%) were malignant. Pleomorphic adenoma was the commonest lesion observed accounted for 68.08%. Conclusion:The Overall sensitivity, specificity and diagnostic accuracy were 80%, 94.74% and 91.66% respectively. FNAC of the salivary gland is safe, rapid ,accurate and reliable technique in the primary diagnosis of salivary gland lesions and useful in avoiding surgery (in inflammatory lesions) or limiting surgical procedures(in benign tumours).

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Diagnostic accuracy of fine‐needle aspiration cytology in Warthin tumors

Abstract: The diagnostic accuracy of FNAC for the diagnosis of Warthin tumor is high and the percentage of missed malignant tumors is very low. Our results imply that a cytologic diagnosis of Warthin tumor may justify conservative treatment.

Cited by 46 publications

References 32 publications

Correct Diagnosis of Warthin Tumor in the Parotid Gland with Dynamic MRI

Correct Diagnosis of Warthin Tumor in the Parotid Gland with Dynamic MRI

Diagnostic Accuracy and Pitfalls in Fine Needle Aspiration Cytology Of Salivary Gland Lesions.

Cytological and Histomorphological Correlation of Salivary Gland Lesions- An Experience at Rural Tertiary Healthcare Hospital

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