Diagnostic accuracy of DWI in patients with ovarian cancer

Yuan, Xia; Guo, Linghong; Du, Wei; Mo, Fei; Liu, Ming

doi:10.1097/md.0000000000006659

Cited by 12 publications

(9 citation statements)

References 49 publications

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“…The other subgroup analysis showed that better sensitivity was achieved when considering only the gastrointestinal tumors, suggesting that DWI could perform better for PMs from gastrointestinal tumors than from ovarian tumors. This is supported by a previous meta-analysis that revealed 86% sensitivity and 81% specificity for PMs from ovarian cancer, [ 29 ] which are lower than in the present meta-analysis. A meta-analysis of patients with cervical cancer showed that PET-CT was better than DWI for the detection of positive lymph nodes.…”

Section: Discussionsupporting

confidence: 89%

Diagnostic value of diffusion-weighted imaging/magnetic resonance imaging for peritoneal metastasis from malignant tumor

Dong¹,

Li²,

Peng³

2021

Medicine

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Background: Previous meta-analyses examined either multiple tools for the diagnosis of peritoneal metastases (PMs), but not diffusion-weighted imaging (DWI), or included only 1 tumor type. This study aimed to determine the summary diagnostic value of DWI/magnetic resonance imaging in determining PMs originating from various tumors. Methods: PubMed, Embase, and Cochrane library were searched for available papers up to 2019/12. Pooled estimates for sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and accuracy were calculated using random-effects models. Results: Ten studies were included and could be used to calculate the pooled sensitivity and specificity. The pooled sensitivity of DWI for PMs was 89% (95% confidence interval [CI]: 83%–93%). The pooled specificity was 86% (95% CI: 79%–91%). When considering only the retrospective studies, the pooled sensitivity of DWI for PMs was 85% (95% CI: 81%–89%). The pooled specificity was 84% (95% CI: 72%–92%). When considering only the studies about gastrointestinal tumors, the pooled sensitivity of DWI for PMs was 97% (95% CI: 68%–100%). The pooled specificity was 86% (95% CI: 69%–95%). No publication bias was observed ( P = dd.27). Conclusion: DWI magnetic resonance imaging is highly sensitive and specific for the detection of PMs from various abdominal cancers.

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Section: Discussionsupporting

confidence: 89%

Diagnostic value of diffusion-weighted imaging/magnetic resonance imaging for peritoneal metastasis from malignant tumor

Dong¹,

Li²,

Peng³

2021

Medicine

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“…Compared with other studies of the efficacy and relative efficacy of DWI/MRI in colorectal cancer [10,11], ovarian cancer [12,13] and stomach cancer [14,15], similar results are obtained, illustrating the reproducibility of the experiment regardless of the treatment center used, study protocols, and subjective evaluation of PCI ranking results. The obtained results allow us to recommend DWI/MRI for pre-operative staging at all three investigated localizations of the tumour process.…”

Section: Discussion Of the Resultssupporting

confidence: 71%

Magnetic Resonance Imaging With Diffuse Weighted Imaging and Computed Tomography With Intravenous Contrast in Staging of Disseminated Ovarian, Stomach, Colorectal Cancer

Четвериков

Zavoloka

Onyshchenko

et al. 2019

EUREKA: Health Sciences

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The aim of the research. Development and implementation of new methods for pre-operative staging of advanced ovarian, gastric and colorectal cancer to improve patient selection for cytoreductive surgery and increase its radicality. Materials and methods. Data from 120 patients with advanced ovarian cancer, 28 with advanced gastric cancer and 119 with advanced colorectal cancer were analyzed. Preoperative detection of the incidence of peritoneal carcinoma and the possibility of surgery in radical or cytoreductive volume performed by CT with intravenous contrast (72 patients with ovarian cancer, 17 patients with gastric cancer, and 69 patients with colorectal cancer), and MR T1 and T2, contrast-enhanced T1, and diffuse-weighted sequences (48 patients with ovarian cancer, 11 patients with gastric cancer, and 50 patients with colorectal cancer). Subsequently, preoperative and intraoperative assessment of the prevalence of the tumour process with peritoneal carcinoma index (PCI) by Sugarbaker was performed. Results. A statistically significant increase in the informativeness of the preoperative assessment of the incidence of tumour process in peritoneum and the presence of distant metastases using DWI / MRI compared with CT with intravenous contrast was determined. Patients from all groups were categorized according to the completeness index of cytoreduction achieved by preoperative staging and patient selection using DWI / MRI and CT. The use of DWI / MRI allowed to significantly reduce the number of suboptimal and non-optimal cytoreductive interventions. Conclusions. DWI / MRI has made it possible to significantly improve the preoperative incidence of advanced ovarian, gastric, and colorectal cancer compared to CT, predict the radicality of future surgery, and detect inoperable cases.

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“…Furthermore, teratomas and endometriomas can be accurately diagnosed on conventional MRI and do not represent diagnostic challenges. Other studies (33)(34)(35) also demonstrated that DWI can differentiate malignancies from benign ovarian tumors. The evaluation methods in these previous studies were based on DWI sequences, a qualitative method that is particularly susceptible to researcher bias.…”

Section: Discussionmentioning

confidence: 88%

Utility of DWI with quantitative ADC values in ovarian tumors: a meta-analysis of diagnostic test performance

Cao

Qiang

et al. 2018

Acta Radiol

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Background Diffusion-weighted imaging (DWI) and quantitative apparent diffusion coefficient (ADC) values are widely used in the differential diagnosis of ovarian tumors. Purpose To assess the diagnostic performance of quantitative ADC values in ovarian tumors. Material and Methods PubMed, Embase, the Cochrane Library, and local databases were searched for studies assessing ovarian tumors using quantitative ADC values. We quantitatively analyzed the diagnostic performances for two clinical problems: benign vs. malignant tumors and borderline vs. malignant tumors. We evaluated diagnostic performances by the pooled sensitivity and specificity values and by summary receiver operating characteristic (SROC) curves. Subgroup analyses were used to analyze study heterogeneity. Results From the 742 studies identified in the search results, 16 studies met our inclusion criteria. A total of ten studies evaluated malignant vs. benign ovarian tumors and six studies assessed malignant vs. borderline ovarian tumors. Regarding the diagnostic accuracy of quantitative ADC values for distinguishing between malignant and benign ovarian tumors, the pooled sensitivity and specificity values were 0.91 and 0.91, respectively. The area under the SROC curve (AUC) was 0.96. For differentiating borderline from malignant tumors, the pooled sensitivity and specificity values were 0.89 and 0.79, and the AUC was 0.91. The methodological quality of the included studies was moderate. Conclusion Quantitative ADC values could serve as useful preoperative markers for predicting the nature of ovarian tumors. Nevertheless, prospective trials focused on standardized imaging parameters are needed to evaluate the clinical value of quantitative ADC values in ovarian tumors.

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Diagnostic accuracy of DWI in patients with ovarian cancer

Cited by 12 publications

References 49 publications

Diagnostic value of diffusion-weighted imaging/magnetic resonance imaging for peritoneal metastasis from malignant tumor

Diagnostic value of diffusion-weighted imaging/magnetic resonance imaging for peritoneal metastasis from malignant tumor

Magnetic Resonance Imaging With Diffuse Weighted Imaging and Computed Tomography With Intravenous Contrast in Staging of Disseminated Ovarian, Stomach, Colorectal Cancer

Utility of DWI with quantitative ADC values in ovarian tumors: a meta-analysis of diagnostic test performance

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