Diagnostic Accuracy of Cord Bilirubin to Predict the Need for Phototherapy in Healthy Neonates &gt;35-Week Gestational Age: A Systematic Review and Meta-Analysis

Anne, Rajendra Prasad; Rahiman, Emine A; Dudeja, Sankalp; Kumar, Ashutosh

doi:10.1016/j.jceh.2022.11.011

Cited by 1 publication

(1 citation statement)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several works in the past have also tried to identify early predictors that could efficiently earmark neonates with an elevated risk of needing phototherapy. Potential markers explored in these studies include initial cord bilirubin concentrations; the relative ratio of TcB to total serum bilirubin in conjunction with vital clinical parameters, like GA; and sophisticated machine learning models that synthesize data points-like bilirubin concentrations, neonatal weight, GA, and hours elapsed since birth-for predictive purposes [27][28][29].…”

Section: Discussionmentioning

confidence: 99%

Early-Term Neonates Demonstrate a Higher Likelihood of Requiring Phototherapy Compared to Those Born Full-Term

Tan,

Chen,

Lin

et al. 2023

Children

View full text Add to dashboard Cite

Early-term neonates (with a gestational age (GA) of 37 and 0/7 weeks to 38 and 6/7 weeks) face higher morbidities, including respiratory and neurodevelopmental issues, than full-term (39 and 0/7 weeks to 40 and 6/7 weeks) infants. This study explores whether hyperbilirubinemia necessitating phototherapy also differs between these groups. A retrospective study was conducted on neonates born from January 2021–June 2022, excluding those with specific conditions. Evaluated factors included GA, birth weight, bilirubin levels, glucose-6-phosphate dehydrogenase (G6PD) deficiency, and feeding type, with phototherapy given as per AAP guidelines. Of 1085 neonates, 356 met the criteria. When stratifying the neonates based on the need for phototherapy, a higher proportion of early-term neonates required phototherapy compared to full-term (p < 0.05). After factoring in various risks (GA; birth weight; gender; feeding type; G6PD deficiency; transcutaneous bilirubin levels at 24 h and 24–48 h postpartum; maternal diabetes; and the presence of caput succedaneum or cephalohematoma), early-term neonates were more likely to need phototherapy than full-term babies (OR: 2.15, 95% CI: 1.21 to 3.80). The optimal cut-off for transcutaneous bilirubin levels 24–48 h postpartum that were used to predict phototherapy need was 9.85 mg/dl. In conclusion, early-term neonates are at a greater risk for developing jaundice and requiring phototherapy than full-term neonates. Monitoring bilirubin 24–48 h postpartum enhances early prediction and intervention.

show abstract

Section: Discussionmentioning

confidence: 99%