Diagnostic accuracy of concentric needle jitter in myasthenia: Prospective study

Machado, Flavia Costa Nunes; Kouyoumdjian, João Aris; Marchiori, Paulo Eurípedes

doi:10.1002/mus.25229

Cited by 13 publications

(7 citation statements)

References 18 publications

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“…In GMG a sensitivity of 76.9% and specificity of 35.7% is calculated for the test; while CNE-SFEMG for OMG cases showed a sensitivity of 82.4% and specificity of 64.7%. These results are comparable to the previous studies in the calculated sensitivity; however, three studies report higher (96-100%) specificity [28,29,33] and one study reported 17.2-17.9% specificity in a large Asian cohort [24]. Receivers Operating Characteristic (ROC) curves were also constructed for our patients' results, to define maximal sensitivity and specificity of the technique and to demonstrate the diagnostic accuracy of CNE-SFEMG, showing 67.6%, 62.5% and 73.5% accuracy for all MG, GMG and OMG respectively.…”

Section: Open Access Journal Of Neurology and Neurosurgerysupporting

confidence: 89%

“…Few papers have reported the sensitivity of CNE-SFEMG in MG [28][29][30][31][32][33][34], and a small number of them have also addressed their specificity [24,28,29,33]. Our study's findings reaffirm the high sensitivity of the CNE-SFEMG test in the diagnosis of MG. Abnormal CNE-SFEMG results were detected in 79.1%, 77% and 82.4% of all MG, GMG and OMG patients respectively.…”

Section: Open Access Journal Of Neurology and Neurosurgerysupporting

confidence: 80%

“…Receivers Operating Characteristic (ROC) curves were also constructed for our patients' results, to define maximal sensitivity and specificity of the technique and to demonstrate the diagnostic accuracy of CNE-SFEMG, showing 67.6%, 62.5% and 73.5% accuracy for all MG, GMG and OMG respectively. Higher ROC curves' values are reported in other studies [24,33]. For most previously published studies, CNE-SFEMG has a higher sensitivity in GMG and a relatively lower sensitivity in OMG [28][29][30][31][32][33][34].…”

Section: Open Access Journal Of Neurology and Neurosurgerymentioning

confidence: 60%

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The Utility of Concentric Needle Single Fiber Electromyography in Diagnosing Myasthenia Gravis

Nadeem¹

2021

OAJNN

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Introduction: Myasthenia Gravis (MG) is a chronic autoimmune neuromuscular disorder, characterized by varying degrees of fluctuating muscular weakness and fatigability. The diagnosis of MG can be difficult and, therefore, bed-side clinical testing, electrophysiological investigations; as well as serum antibodies tests are often used to establish the diagnosis. Objective:The aim of this study was to define the diagnostic accuracy of concentric needle electrode single fiber electromyography (CNE-SFEMG) jitter test in MG patients and to determine its' diagnostic value by calculating the sensitivity, specificity, predictive values and accuracy of the test.Methods: Retrospective analysis of 74 Omani MG patients' data was carried out to determine the diagnostic sensitivity, specificity and predictive values of CNE-SFEMG test; against a reference standard of MG by virtue of clinical features, antibody assay and response to treatment.Receiver Operating Characteristic (ROC) curve was plotted and the area under the ROC curve (AUC) was also calculated to measure the accuracy of the test. A comparison of the frequency of CNE-SFEMG abnormality between ocular (OMG) and generalized (GMG) myasthenia gravis patients was done.Results: Abnormal CNE-SFEMG results were detected in 79.1%, 77% and 82.4% of all MG, GMG and OMG patients respectively. Based on the reference standard used, the sensitivity, specificity and predictive values were determined, and the test accuracy was measured in all MG, GMG and OMG included patients. CNE-SFEMG had a sensitivity of 79.1 % and specificity of 51.6 % in all MG patients with 67.6% test accuracy. In GMG, CNE-SFEMG had a sensitivity of 76.9%, specificity of 35.7% and 62.5% accuracy of the test; while CNE-SFEMG for OMG cases showed a sensitivity of 82.4% and specificity of 64.7% with 73.5% test accuracy.The CNE-SFEMG abnormality was more frequent in the ocular than the generalized MG patients but with insignificant statistical difference. Conclusion:Our findings indicate that CNE-SFEMG is a very useful and valid test for MG and our results were comparable, but lower than previously published values.Significance: The sensitivities, specificity, predictive values and test accuracy of CNE-SFEMG jitter in the diagnosis of MG cases attending the neuromuscular unit at a tertiary care hospital in Muscat-Oman were documented.

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Section: Open Access Journal Of Neurology and Neurosurgerysupporting

confidence: 89%

Section: Open Access Journal Of Neurology and Neurosurgerysupporting

confidence: 80%

Section: Open Access Journal Of Neurology and Neurosurgerymentioning

confidence: 60%

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The Utility of Concentric Needle Single Fiber Electromyography in Diagnosing Myasthenia Gravis

Nadeem¹

2021

OAJNN

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“…Similarly, in a systematic review, Benatar (7) confirmed a high specificity of SFEMG for the diagnosis of GMG. For OMG, the sensitivity ranged from as low as 62% (7) to as high as 100% (8,9). Mercelis and Merckaert (10) found a specificity of 97% and a sensitivity of 80% for OMG in stimulated-SFEMG for Orbicularis Oculi (OO).…”

Section: Introductionmentioning

confidence: 99%

“…Disposable concentric needle electrodes (CNE) is currently used for jitter measurement (5,11), due to the increasing concern for the transmission of infections. Some papers have presented normative data and the diagnostic value of the test in MG (5,9,(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21). Farrugia et al (22) found no difference in mean jitter values for Extensor Digitorum (ED) and OO muscles in 24 MG patients using both single fiber electrode (SFE) and CNE.…”

Section: Introductionmentioning

confidence: 99%