Diagnostic Accuracy of Cardiac MRI versus FDG PET for Cardiac                     Sarcoidosis: A Systematic Review and Meta-Analysis

Aitken, Matthew; Chan, Michael Vinchill; Fresno, Camila Urzua; Farrell, Ashley; Islam, Nasir; McInnes, Matthew D. F.; Iwanochko, Robert M.; Balter, Meyer; Moayedi, Yasbanoo; Thavendiranathan, Paaladinesh; Metser, Ur; Veit-Haibach, Patrick; Hanneman, Kate

doi:10.1148/radiol.213170

Cited by 46 publications

(18 citation statements)

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“…v i a m e d i c a . p l / k a r d i o l o g i a _ p o l s k a with the endomyocardial biopsy, is its sensitivity for detection of cardiac sarcoidosis, which is reported to be 90%--100% [7,8], whereas the sensitivity of the endomyocardial biopsy is only about 25% [9]. The diagnosis of myocardial involvement based on the CMR study is traditionally based on the presence of LGE of non-ischemic etiology found in the subepicardial or midmyocardial segments of the LV walls, often involving the basal LV segments including the interventricular septum [10].…”

Section: Discussionmentioning

confidence: 99%

Role of magnetic resonance in the detection of cardiac involvement in patients with newly diagnosed extracardiac sarcoidosis: Single center experience

et al. 2022

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Background: Sarcoidosis is a systemic inflammatory disease of unknown etiology, which can affect almost any organ. Cardiac involvement determines the prognosis of the affected individuals. Its prevalence in patients with extracardiac sarcoidosis with the absence of cardiac symptoms remains unclear. Cardiac magnetic resonance (CMR) provides excellent diagnostic accuracy in the detection of heart involvement by sarcoidosis. Aim:We sought to determine the prevalence of cardiac sarcoidosis in asymptomatic individuals with newly diagnosed extracardiac sarcoidosis using CMR. Methods:We prospectively evaluated 55 consecutive patients including 23 women with newly diagnosed extracardiac sarcoidosis who underwent contrast-enhanced CMR and had no symptoms of heart disease. The mean (standard deviation) age of patients was 43 (11) years. The presence of myocardial late gadolinium enhancement (LGE) of non-ischemic etiology on CMR examination was considered diagnostic for cardiac sarcoidosis. Results:In 3 (6%) patients, the LGE pattern consistent with cardiac sarcoidosis was detected. In all patients, preserved left ventricular systolic regional and global function was present, and in none of them, the elevation of blood biomarkers of myocardial injury or overload was found. Conclusions:Our study suggests that the prevalence of cardiac involvement in patients with newly diagnosed extracardiac sarcoidosis and no symptoms of heart disease is very low as assessed by CMR. However, CMR may be considered as part of routine evaluation of patients with extracardiac sarcoidosis due to its higher diagnostic yield in comparison with echocardiography and electrocardiography, respectively.

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Section: Discussionmentioning

confidence: 99%

Role of magnetic resonance in the detection of cardiac involvement in patients with newly diagnosed extracardiac sarcoidosis: Single center experience

et al. 2022

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“…Furthermore, [ 18 F]FDG PET is an imaging method with growing interest for the diagnosis of sarcoidosis. In a recent metanalysis, [ 18 F]FDG PET/CT has been demonstrated to have a specificity similar to cardiac MRI in diagnosing cardiac sarcoidosis, although with a lower sensitivity [ 55 ]. Several studies assessed the role of [ 18 F]FDG PET/CT in the diagnosis of large-vessel vasculitis and in monitoring the disease’s activity.…”

Section: Discussionmentioning

confidence: 99%

COVID-19 vaccination, implications for PET/CT image interpretation and future perspectives

Kirienko

Biroli

Pini

et al. 2022

Clin Transl Imaging

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Introduction The present paper aims to systematically review the literature on COVID-19 vaccine-related findings in patients undergoing PET/CT. Methods The search algorithms included the following combination of terms: “PET” OR “positron emission tomography” AND “COVID”; “PET” OR “positron emission tomography” AND “COVID” AND “vaccination”; “PET” OR “positron emission tomography” AND “COVID”, AND “autoimmune”. Results We selected 17 articles which were assessed for quality and included in the systematic analysis. The most frequent vaccine-related signs on PET/CT were the deltoid [ 18 F]FDG uptake and axillary hypermetabolic lymph nodes, which were described in 8–71% and 7–90% of the patients, respectively. Similarly, frequency of these findings using other tracers than [ 18 F]FDG was greatly variable. This large variability was related to the variability in time elapsed between vaccination and PET/CT, and the criteria used to define positivity. In addition, vaccine-related findings were detected more frequently in young and immunocompetent patients than in elderly and immunocompromised ones. Discussion Therefore, awareness on vaccination status (timing, patient characteristics, and concurrent therapies) and knowledge on patterns of radiopharmaceutical uptake are necessary to properly interpret PET/CT findings.

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“…44 Positron Emission Tomography 18 F-fluorodeoxyglucose (FDG) is a glucose analogue commonly used to image metabolically active processes such as malignancy and inflammation using positron emission tomography (PET). Although cardiac-gated FDG-PET is most frequently used in the setting of cardiac sarcoidosis, 45 FDGuptake is also identified in acute myocarditis, reflecting metabolically active inflammatory cells (Figure 6). The myocardium is normally glucose avid and therefore a diet preparation protocol is required to suppress physiologic myocardial activity that could mask inflammation.…”

Section: Computed Tomographymentioning

confidence: 99%

Cardiac Imaging in Myocarditis: Current Evidence and Future Directions

et al. 2022

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Myocarditis is defined as a non-ischemic inflammatory disease of the myocardium. It remains a challenge to diagnose given non-specific symptoms and lack of specific blood biomarkers. Cardiac imaging plays an important role in the evaluation of myocarditis with unique strengths and limitations of different imaging modalities, including cardiac magnetic resonance imaging, echocardiography, cardiac computed tomography, and positron emission tomography. The purpose of this review is to discuss the strengths and limitations of various cardiac imaging techniques in the evaluation of myocarditis, review imaging findings in specific causes of myocarditis including COVID-19 and after vaccination, evaluate the role of imaging in differentiating myocarditis from potential mimics and differential considerations, identify current gaps in knowledge, and propose future directions.

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Diagnostic Accuracy of Cardiac MRI versus FDG PET for Cardiac Sarcoidosis: A Systematic Review and Meta-Analysis

Cited by 46 publications

References 54 publications

Role of magnetic resonance in the detection of cardiac involvement in patients with newly diagnosed extracardiac sarcoidosis: Single center experience

Role of magnetic resonance in the detection of cardiac involvement in patients with newly diagnosed extracardiac sarcoidosis: Single center experience

COVID-19 vaccination, implications for PET/CT image interpretation and future perspectives

Cardiac Imaging in Myocarditis: Current Evidence and Future Directions

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