Diagnostic accuracy of anti-cyclic citrullinated peptide antibodies in juvenile idiopathic arthritis

Kasapçopur, Özgür; Altun, Sibel; Aslan, Mustafa; Karaarslan, S; Kamburoglu-Göksel, A; Sarıbaş, Suat; Arısoy, Nı̇l; Kocazeybek, Bekir

doi:10.1136/ard.2003.019331

Cited by 58 publications

(50 citation statements)

References 14 publications

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“…Our findings showed that the prevalence rates of all ACPAs in the whole population of JIA patients were less than 30% and much lower than those of adult RA patients, which agrees with the results reported in previous studies on anti-CCP (Avcin et al, 2002;Bongi et al, 2004;Kasapçopur et al, 2004;Kwok et al, 2005;Gilliam et al, 2011;Tebo et al, 2012). Therefore, we confirmed that ACPAs cannot serve as screening biomarkers for the general JIA population due to their low sensitivity.…”

Section: Discussionsupporting

confidence: 81%

Diagnostic performance of anti-citrullinated protein/peptide antibodies in juvenile idiopathic arthritis

et al. 2016

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ABSTRACT. The prevalence rates of anti-citrullinated protein/peptide antibodies (ACPAs) were investigated in a cohort of juvenile idiopathic arthritis (JIA) patients, and their diagnostic performances were compared. ACPAs, including anti-cyclic citrullinated peptide IgG (anti-CCP), anti-CCP IgG/IgA (anti-CCP3.1), citrullinated recombinant rat filaggrin antibodies (CPA), anti-mutated citrullinated vimentin (anti-MCV), and antibodies to citrullinated human IgG-derived peptides (RA/CP), were measured in the sera from 81 JIA patients. Serum samples from 55 children with other joint diseases or viral infections and 49 healthy donors were tested as controls. Of the 81 JIA patients, 7 (8.6%), 8 (9.9%), 17 (21.0%), 23 (28.4%), and 18 (22.2%) were found to be positive for anti-CCP, anti-CCP3.1, CPA, anti-MCV, and RA/CP, respectively, with specificities of 98.1, 95.1, 93.3, 84.6, and 86.5%. Analysis by subtype revealed that 7/7 (100%) of RF-positive polyarticular JIA patients tested positive at high serum levels for anti- MCV or RA/CP, and 5/7 (71.4%) were positive for anti-CCP, anti-CCP3.1, or CPA (P < 0.001, compared with controls). Eighteen of 81 JIA patients demonstrated joint erosions on radiographs and erosive arthritis occurred more often in ACPAs positive patients (P < 0.01). Our findings indicate that although ACPAs are not satisfactory screening biomarkers for JIA due to low sensitivity, ACPA measurement can aid in diagnosing RF-positive polyarticular JIA and identifying JIA patients with severe bone involvement. The diagnostic performance of each ACPA in JIA is different, and the careful selection of assays is necessary.

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Section: Discussionsupporting

confidence: 81%

Diagnostic performance of anti-citrullinated protein/peptide antibodies in juvenile idiopathic arthritis

et al. 2016

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“…18 The first three studies about anti-CCP Abs in childhood reported 2%-5% anti-CCP positivity. [12][13][14] Hromadnikova et al found seven children (5%) with anti-CCP. Two of them were diagnosed as having RF polyarticular JIA.…”

Section: Discussionmentioning

confidence: 97%

“…[12][13][14][15][16][17][18][19] Five of them investigated children with JIA, but in the other studies, patients with JIA served as the control group for RA. In the study of Lee all anti-CCP-positive patients had an RF-positive polyarticular JIA, 19 and Bizarro et al found none of their three JIA patients to be anti-CCP positive.…”

Section: Discussionmentioning

confidence: 99%

Anticyclic citrullinated peptide antibodies in juvenile idiopathic arthritis

Brunner

Sitzmann

2006

Mod Rheumatol

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Anticyclic citrullinated peptide (anti-CCP) antibodies have been detected in patients with juvenile idiopathic arthritis (JRA), particularly in those with polyarticular JIA. We analyzed the presence of anti-CCP antibodies of the IgG class in sera of patients with defined juvenile idiopathic arthritis (JIA) of various subgroups. One hundred and fifty-nine serum samples were investigated. Forty-five patients were diagnosed with JIA (15 male and 30 female) aged 1.9-17.3 years (median 12.9, mean 11.0). Thirty-eight samples were taken from patients suffering from other autoimmunopathies and 34 patients with other underlying diseases were taken at different time points in their disease course. Under 42 samples were taken from patients with noninflammatory diseases. Enzyme-linked immunosorbent assay (ELISA) was used for the detection of anti-CCP antibodies. Anti-CCP antibodies were found in 6.9% of all samples and in 4.4% patients with JIA. Disease duration and medication did not differ significantly between anti-CCP positive and negative patients. A review of the literature and our own results shows that anti-CCP antibodies can be detected in the sera of only some patients with JIA. Routine determination of anti-CCP cannot be recommended.

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“…Overall, anti-CCP Abs were found in 5% (7/140) patients including 3/52 RF-negative polyarthritis, 2/18 RF-positive polyarthritis, 1/15 ERA, and 1/5 unclassifiable arthritis. Kasapçopur et al [6] detected anti-CCP Abs in 2% (3/122) of children with JIA. Twelve of them had RF-positive polyarticular JIA.…”

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confidence: 99%

“…However, their presence fis not reflated to tThe dfisease course or to tThe severfity off tThe jofint involvement [2]. Anti-CCP Abs have been studied in children a few times [3][4][5][6][7]. Reviewing the literature, Low et al [7] found anti-CCP Abs in 77% (51/66) patients with JIA, including 15/18 (83%) RF-negative polyarthritis, 12/16 (75%) RF-positive polyarthritis, 16/19 (84%) oligoarthritis, 8/13 (62%) systemic arthritis.…”

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confidence: 99%

Anticyclic Citrullinated Peptide Antibody: A Predictor of Juvenile Idiopathic Arthritis Progression Toward Rheumatoid Arthritis

Ghaffarpas¹

2012

J Med Diagn Meth

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Rheumatoid Arthritis (RA) has been associated with several autoantibodies, including antiperinuclear factor, anti-keratin antibodies, anti-filaggrin antibodies, and anti-Cyclic Citrullinated Peptide (anti-CCP) antibodies. Most studies found that anti-CCP antibodies are only detected in Juvenile Rheumatoid Arthritis (JRA) patients with positive Rheumatoid Factor (RF). In our center we experimentally observed that children with Juvenile Idiopathic Arthritis (JIA) that tested positive for anti-CCP Abs were also tested positive for RF. In seven years of follow-up of these 86 patients, 63 (73.2%) developed RA. It can be hypothesized that the antibodies against CCP plays an important role in progression of the JIA towards RA. On the other hand anti-CCP Abs may play a role in the pathogenesis of RA. Further studies are needed to clarify this association.

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Diagnostic accuracy of anti-cyclic citrullinated peptide antibodies in juvenile idiopathic arthritis

Cited by 58 publications

References 14 publications

Diagnostic performance of anti-citrullinated protein/peptide antibodies in juvenile idiopathic arthritis

Diagnostic performance of anti-citrullinated protein/peptide antibodies in juvenile idiopathic arthritis

Anticyclic citrullinated peptide antibodies in juvenile idiopathic arthritis

Anticyclic Citrullinated Peptide Antibody: A Predictor of Juvenile Idiopathic Arthritis Progression Toward Rheumatoid Arthritis

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