Diagnostic accuracy of 18 F-FDG-PET and PET/CT in patients with Ewing sarcoma family tumours: a systematic review and a meta-analysis

Treglia, Giorgio; Salsano, Marco; Stefanelli, Antonella; Mattoli, Maria Vittoria; Giordano, Alessandro; Bonomo, Lorenzo

doi:10.1007/s00256-011-1298-9

Cited by 107 publications

(57 citation statements)

References 18 publications

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“…ES cells also showed a higher GAPDH expression, with particular regard to the SK-N-MC cells, reflecting a higher glycolytic activity. In keeping with the in vitro high glucose consumption of ES cells, the sensitivity, specificity, and accuracy of FDG-PET in this tumor have relevant impacts on treatment [35]. Using this approach, we therefore concluded that ES cells develop a compensatory response to adverse local environment that facilitates tumor progression through the simultaneous activation of mitochondrial respiration and upregulation of glycolysis.…”

Section: Discussionmentioning

confidence: 87%

V-ATPase is a candidate therapeutic target for Ewing sarcoma

Avnet

Pompo

Lemma

et al. 2013

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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Suppression of oxidative phosphorylation combined with enhanced aerobic glycolysis and the resulting increased generation of protons are common features of several types of cancer. An efficient mechanism to escape cell death resulting from intracellular acidification is proton pump activation. In Ewing sarcoma (ES), although the tumor-associated chimeric gene EWS-FLI1 is known to induce the accumulation of hypoxia-induced transcription factor HIF-1α, derangements in metabolic pathways have been neglected so far as candidate pathogenetic mechanisms. In this paper, we observed that ES cells simultaneously activate mitochondrial respiration and high levels of glycolysis. Moreover, although the most effective detoxification mechanism of proton intracellular storage is lysosomal compartmentalization, ES cells show a poorly represented lysosomal compartment, but a high sensitivity to the anti-lysosomal agent bafilomycin A1, targeting the V-ATPase proton pump. We therefore investigated the role of V-ATPase in the acidification activity of ES cells. ES cells with the highest GAPDH and V-ATPase expression also showed the highest acidification rate. Moreover, the localization of V-ATPase was both on the vacuolar and the plasma membrane of all ES cell lines. The acidic extracellular pH that we reproduced in vitro promoted high invasion ability and clonogenic efficiency. Finally, targeting V-ATPase with siRNA and omeprazole treatments, we obtained a significant selective reduction of tumor cell number. In summary, glycolytic activity and activation of V-ATPase are crucial mechanisms of survival of ES cells and can be considered as promising selective targets for the treatment of this tumor.

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Section: Discussionmentioning

confidence: 87%

V-ATPase is a candidate therapeutic target for Ewing sarcoma

Avnet

Pompo

Lemma

et al. 2013

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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“…PET/CT has very high sensitivity and specificity of 96% and 92%, respectively, for detecting EESs. 17 Similar to skeletal ESSs, EESs are 18 F-FDG-avid tumours ( Figure 2). The mean SUVmax of the primary tumours in our study was 7 (range, 3-11).…”

Section: Discussionmentioning

confidence: 99%

Multimodality imaging features, metastatic pattern and clinical outcome in adult extraskeletal Ewing sarcoma: experience in 26 patients

Somarouthu¹,

Shinagare²,

Rosenthal³

et al. 2014

BJR|case reports

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Objective: To describe the multimodality imaging features, metastatic pattern and clinical outcome in adult extraskeletal Ewing sarcoma (EES). Methods: In this institutional review board-approved, health insurance portability and accountability act-compliant retrospective study, we included 26 patients (17 females and 9 males; mean age, 36 years; range, 18-85 years) with pathologically confirmed EES seen at our institute between 1999 and 2011, who had imaging of primary tumour. Imaging of primary tumour in all 26 patients and follow-up imaging in 23 was reviewed by two radiologists in consensus. Clinical data were extracted from electronic medical records. Results: The most common primary sites were the torso (n 5 13), extremities (n 5 10) and head and neck (HN) region (n 5 3). The mean tumour size was 9 cm (range, 3-22 cm); tumours of the torso were larger than those of other areas (p . 0.05). Compared with the skeletal muscle, tumours were isodense on CT (21/21), hypointense (n 5 5) to isointense (n 5 14) on T 1 weighted image, hyperintense on T 2 weighted image (19/19) and were fluorine-18 fludeoxyglucose ( 18

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“…Específicamente, en familia Ewing y PNET la adición de imáge-nes híbridas con TC a las tradicionales con PET efectuado con FDG es importante (sensibilidad, especificidad y precisión de PET: 71%, 95% y 88%, vs híbrido: 87%, 97% y 94%, respectivamente; ambas metodologías tienen relevancia e impacto en la estrategia de tratamiento 15,17 . En sarcomas óseos, uno de los factores pronósticos más importantes es la respuesta a la terapia que puede ser medida como porcentaje de necrosis y se puede observar como hipometabolismo central 13 .…”

Section: Discussionunclassified