Diagnosis value of focal liver lesions with SonoVue®-enhanced ultrasound compared with contrast-enhanced computed tomography and contrast-enhanced MRI: a meta-analysis

Yang, Guang; Xie, Liangdi; Ding, Hailong; Cai, Ailong; Huang, Ying

doi:10.1007/s00432-011-1035-8

Cited by 70 publications

(56 citation statements)

References 55 publications

(39 reference statements)

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“…The cirrhotic liver represents a particular challenge, since small tumors can be hard to distinguish from regeneration nodules. Contrast enhanced ultrasound has been shown to be a very useful method in this respect, yielding similar diagnostic utility as MRI and CT [98] . In difficult cases, a combination of the different methods is often needed.…”

Section: Trendsmentioning

confidence: 99%

Effect of liver regeneration on malignant hepatic tumors

Shi

Line

2014

WJG

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Liver regeneration after major surgery may activate occult micrometastases and facilitate tumor growth, leading to liver tumor recurrence. Molecular changes during liver regeneration can provide a microenvironment that stimulates intrahepatic tumor propagation through alterations in cellular signaling pathways, where activation and proliferation of mature hepatocytes, hepatic progenitor cells, non-parenchymal liver cells might favor both liver regeneration and tumor growth. This review highlights recent advances of tumor growth and development in the regenerating liver, possible mechanisms and clinical implications. Key words: Hepatocellular carcinoma; Colorectal cancer; Recurrence; Liver regeneration; Hepatic progenitor cell; Epithelial to mesenchymal transition Core tip: The liver has a unique capacity for regeneration after cellular damage or partial removal of tissue, and modern liver surgery relies on this property. Liver regeneration is a complex process involving a large array of growth factors, cytokines and cells to restore hepatic mass and function. Experimental and clinical data indicate that the regeneration signals facilitate the growth of both primary and secondary liver tumors and can alter their malignant potential. This is an important mechanism underlying recurrence after liver surgery. New therapeutic strategies founded on better insight into the relationship between liver regeneration and tumor biology are needed.Shi JH, Line PD. Effect of liver regeneration on malignant hepatic tumors.

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Section: Trendsmentioning

confidence: 99%

Effect of liver regeneration on malignant hepatic tumors

Shi

Line

2014

WJG

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“…This opinion is shared by Westwood et al and Guang et al who reported that contrast -enhanced ultrasound (CEUS) could provide a similar diagnostic performance to other imaging modalities contrast-enhanced computed tomography (ECT) and contrast-enhanced magnetic resonance imaging (CEMRI) for the assessment of focal liver lesions (FLLs) [29,30]. Ultrasonography can play important role in staging and follow-up of breast cancer patients, particularly in developing countries, where resources for advanced medical imaging is limited [31].…”

Section: IVmentioning

confidence: 90%

Ultrasonography Appearances of Hepatic Metastases from Female Breast Cancer in Patients in Central Sudan

Salih¹,

Elhaj²

2014

IOSRJDMS

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“…There are certain problems with cirrhotic altered liver when malignant neoplasms ≤ 1 cm are difficult to distinguish from the regeneration sites. Ultrasound diagnostics (Ultrasound) with contrast allows differential diagnosis in this area, adding to the data of MRI and CT [22]. In difficult cases, it is important to combine several methods.…”

Section: Clinical Manifestations Of the Regenerative Ability Of Livermentioning

confidence: 99%

Metabolic changes from liver regeneration after metastatic colorectal cancer surgery

Burlaka

Zvirych²,

Dorozhinskiy³

et al. 2017

Nowotwory. Journal of Oncology

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Background. The pathological effect of the surgical ischemia-reperfusion technique is a cause for the development of liver damage and occurrence of acute liver failure during the postoperative period in cancer patients after major resection as well as after transplantation. Despite the urgency of the problem, most of the pathological processes that accompany the above-mentioned conditions are still only incompletely studied. Objective. To investigate the mechanisms of the damaging effects of stress reaction after liver resection, to evaluate the functional state of residual liver tissue and to find ways to influence the regeneration and apoptosis of the resected liver, which in the future would make the liver surgery safer. Methods. The results of treatment of 15 patients with colorectal cancer (mCRC) and liver metastases, who had undergone surgery in the period from December 2015 to November 2016 at the National Cancer Institute. Determination of the state of the detoxifying function of hepatocytes and the coupling of biological oxidation and phosphorylation in the mitochondria of hepatocytes were performed by electron paramagnetic resonance at the temperature of liquid nitrogen. Results. It has been found that the levels of the oxidized and low-spin forms of cytochrome P-450 in the catalytic cycle of the detoxification system were 0.33 ± 0.08 relative units and 1.11 ± 0.13 relative units, respectively (the normal levels are 0.59 ± 0.03 relative units and 2.56 ± 0.02 relative units). Also, an increase registered in the levels of formation of complexes of NO-FeS-proteins up to the values of 0.33 ± 0.08 relative units (the normal level is 0.14 ± 0.07). We believe that such changes are the cause of disturbances in the energy function of mitochondria and the formation of cell hypoxia, which correlates with an increase of lactate levels in tissue of the future liver remnant. The liver remnant levels are > 2.00 mM/g·tissue, while the normal is 1.80 ± 0.26 mm/g·tissue. This confirms the functioning of hepatocytes under hypoxic conditions. Conclusions. In the residual liver tissue, we have found a decrease in detoxification system deficiency and the energy supply of hepatocytes. In hepatocytes of the future liver remnant, reprogramming of the metabolism of mitochondria from oxidative phosphorylation in glycolysis is registered, resulting in the formation of cell hypoxia and an increase in levels of lactate and superoxide radicals. To assess the degree of ALF in the postoperative period, we suggest use of the levels of lactate, the activity of cytochrome P-450, the levels of formation of complexes of NO and FeS-proteins in mitochondria ETC and the generation rate of SR as the markers. NOWOTWORY J Oncol 2017; 67, 2: 121-126

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Diagnosis value of focal liver lesions with SonoVue®-enhanced ultrasound compared with contrast-enhanced computed tomography and contrast-enhanced MRI: a meta-analysis

Cited by 70 publications

References 55 publications

Effect of liver regeneration on malignant hepatic tumors

Effect of liver regeneration on malignant hepatic tumors

Ultrasonography Appearances of Hepatic Metastases from Female Breast Cancer in Patients in Central Sudan

Metabolic changes from liver regeneration after metastatic colorectal cancer surgery

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