Diagnosis Sepsis Neonatal

Abstract

Sepsis adalah respon sistemik terhadap infeksi yang disebabkan oleh bakteri, virus, jamur,protozoa atau ricketsia. Insiden sepsis pada neonatus rendah yaitu 1-8 perseribu kelahiranhidup, namun angka kematian lebih dari 20-50 % kasus. Tidak ada satupun pemeriksaantunggal laboratorium yang dapat dipakai untuk diagnosis sepsis neonatal. Skor hematologiRodwell dan atau pemeriksaan imunologi sIL2R dapat dipakai sebagai alat diagnostiksepsis neonatal.

A hematologic scoring system and C-reactive protein compared to blood cultures for diagnosing bacterial neonatal sepsis

“…8 The scoring system consists of 7 findings, each of which are assigned a score of abnormal white blood cell count, abnormal total neutrophil [polymorphonuclear cells (PMN)] count, elevated immature to total PMN ratio, immature to mature neutrophil (IM) ratio > 3, elevated immature PMN count, platelet count < 150,000/mm 3 , and degenerative changes in PMNs. 8,9 C-reactive protein has also been used to diagnose sepsis. The combination of CRP measurement and a hematologic scoring system is expected to be a new modality for rapidly diagnosing neonatal sepsis.…”