Diagnosis, Screening and Treatment of Abdominal, Thoracoabdominal and Thoracic Aortic Aneurysms

Abstract

Dr. Reinhart T. Grundmann works currently as an independent medical expert. He is a professor of surgery at the University of Cologne and he has the qualification of general and vascular surgery. He is the former medical director of the B.Braun company, one of the leading providers of healthcare solutions. In the last eight years he has been working as the medical director of the Clinics Altotting-Burghausen, Germany. Dr. Grundmann was from 1992 until 2008 the managing director of the Zentralblatt fur Chirurgie and he is currently a member of the Editorial Board of World Journal of Gastrointestinal Surgery. He edited from 2001 to 2005 the Jahrbuch der Chirurgie-the book which provides an information on the latest developments in surgery. Dr. Grundmann already published more than 260 scientific publications, including books and the book chapters. His recent research interests lie in the field of efficiency and efectiveness in surgery. In this frame, he published a workflows on liver surgery, gastric cancer, obesity surgery and surgery for abdominal and carotide artery stenosis treatment.

Comparative Ultrastructural and Stereological Analyses of Unruptured and Ruptured Saccular Intracranial Aneurysms

“…Fragmentation of the IEL has been observed before (7,(12)(13)(14) while 1 study also showed that such fragmentation was accompanied by the presence of mast cells (12). Structural remodeling of the IEL involves loss of the original, well organized elastin, and replacement by deposition of much less organized, patches of elastin, called intimal elastic tissue (20). The turnover of vascular elastin is very slow, with a half-life of 60-70 years, which means that structurally functional vascular elastin is primarily produced during childhood (21).…”

“…Upon degradation of elastin in IA, SMCs (22) and macrophages (23) deposit intimal elastic tissue. Although this intimal elastic tissue consists of elastin, its functional properties are lost (20). Clear increase in the intimal elastic tissue deposition in the ruptured IA suggests that further structural remodeling is activated before the rupture.…”

Abdominal aortic aneurysm

“…A systematic review of patients with small AAAs by Bath et al (2015) found that of 2323 patients, the risk of cardiovascular death was 3% per year, prevalence of ischaemic heart disease was 44.9%, myocardial infarction was 26.8%, heart failure was 4.4%, and stroke was 14%. Sidloff et al (2015), in the Aneurysm Global Epidemiology Study, demonstrated a positive linear relationship between AAA mortality and global trends in systolic blood pressure, cholesterol and smoking prevalence. The body mass index demonstrated a negative linear association with AAA mortality.…”