The presented paper deals with the numerical modeling of groundwater response to the extreme hydrological situations in the Danube River. A 3-D numerical groundwater modeling is carried out using MODFLOW (McDonald and Harbaugh, 1998) and Groundwater Modeling System (AQUAVEO, 2021) simulation packages for available hydrological, geological, and hydro-geological parameters to study how the groundwater responded to the flood event in the Danube River that occurred in June 2013.