Diagnosis of solitary fibrous tumor in the submandibular gland: Case report and literature review

Abstract

Solitary fibrous tumors (SFTs) rarely occur in the head and neck area. Imaging findings are nonspecific, and immunohistochemical (IHC) analysis is necessary for a definitive diagnosis. We report the case of a patient with a mass in the submandibular region that was initially diagnosed as basal cell adenoma. After excision and IHC examinations, a SFT was diagnosed.

Solitary fibrous tumour of the submandibular gland: Novel insights from clinical practice on a close mimicker of pleomorphic adenoma and a diagnostic challenge for the cytopathologist

“…Most cases of SFT reported in the literature have been resected without a prior FNA 2‐5,7 . In this case, we demonstrate the challenges for the cytopathologist on ROSE with a retrospective review of the cytomorphological findings.…”

“…Nevertheless, smaller lesions typically demonstrate homogeneous enhancement. Magnetic resonance imaging is the preferred modality of study for tissue characterisation 5 …”

“…The few cases of SFT of the submandibular gland reported in the literature have been surgically removed with rare recurrence, malignant transformation, or metastasis 2‐7 . The preferred treatment strategy for SFTs is complete surgical resection.…”

“…The most common spindle cell lesions of the salivary gland are myoepithelial‐predominant pleomorphic adenoma, myoepithelioma, schwannoma, and less frequently, nodular fasciitis, solitary fibrous tumour (SFT), myoepithelial carcinoma, spindle cell carcinoma, and melanoma 1 . Approximately forty cases of SFTs have been reported in the parotid gland over the past 17 years, 5 cases in the submandibular gland, and 1 in the sublingual gland 2‐7 …”

Solitary Fibrous Tumor: A Rare Differential for Submandibular Gland Swelling

“…Solitary brous tumour is spindle cell neoplasms that commonly arise in the pleura and other serosal regions with more than 50% of these tumours located in the thoracic cavity, however extrathoracic tumours have been reported in various sites such as the liver, skin and the head and neck. Solitary brous tumours (SFTs) of the head and neck region are extremely rare with oral cavity being the most common site (1). SFTs are commonly benign, yet 10% to 15% of extrapleural SFTs have shown malignant characteristics in the form of metastatic disease (2).…”