Diagnosis of Skeletal Metastases in Malignant Extraskeletal Cancers

Schirrmeister, Holger; Arslandemir, Coskun

doi:10.1016/b978-0-12-374895-9.00024-4

Cited by 3 publications

(3 citation statements)

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“…For the cases with new bone formation (n=22), a neoplastic pathogenesis cannot be excluded. As Greenspan and Borys (2016:7) note, "no single periosteal response is hallmark to a particular neoplasm", even if interrupted and rapidly produced bone is more likely to be seen in aggressive neoplasms (Ragsdale, 1993;Burgener et al, 2008;Schirrmeister and Arslandemir, 2010;Costelloe and Madewell, 2016;Greenspan and Borys, 2016). Thus, these discreet areas of bone formation or enlargement of the bone contour could be a response to the neoplastic disease recorded in the cause of death; however their typology and pattern are non-specific.…”

Section: Interpretation Of the Score 2 Resultsmentioning

confidence: 99%

“…Abnormal bone proliferation was recorded, accounting for: i) their distinct visual characteristics (woven/lamellar/mixed, spiculated [hair-on-end, sunburst or coarse patterns], and widening of bone contour); ii) location, extension, number and size. Determination of these macroscopic features can aid in the differentiation between indolent or aggressive lesions, and can also inform the rate of progression (Ragsdale, 1993;Burgener et al, 2008;Schirrmeister and Arslandemir, 2010;Costelloe and Madewell, 2016;Greenspan and Borys, 2016).…”

Section: Methodsmentioning

confidence: 99%

“…Clinically, osseous metastases are generally detected in nearly 25-30% of the patients at initial diagnosis and in ca. 50% for advanced cases (Coleman and Rubinas, 2009;Schirrmeister and Arslandemir, 2010;Kumar et al, 2015). Not all primary neoplastic cell types have equal osseous metastatic propensity.…”

Section: Paleopathological Diagnosismentioning

confidence: 99%

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Absence of evidence or evidence of absence? A discussion on paleoepidemiology of neoplasms with contributions from two Portuguese human skeletal reference collections (19th–20th century)

Marques

Matos

Costa

et al. 2018

International Journal of Paleopathology

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Biological, sociocultural, demographic and environmental factors are major contributors to the contemporary burden of oncological diseases. Although cancer's current epidemiological landscape is fairly well known, its past occurrence and history seem more obscure. In order to test the hypothesis that paleopathological diagnosis is an adequate measure of the prevalence of malignant neoplasms in human remains, 131 skeletons (78 females, 53 males, age-at-death range: 15-93 years) from Coimbra and Lisbon Identified Skeletal Collections, 19th/20th century (Portugal), were examined. The cause of death for all of the selected skeletons was a malignant neoplasm, as recorded in the collection's documental files. Through the application of standard paleopathological protocols, it was determined that 17.6% (n = 23) of the skeletons had unequivocal osseous signs of metastatic and/or neoplastic lesions. Forty-five percent (n = 59) had manifest osseous lesions, however the lesional patterns were not clearly pathognomonic. Although all of the analyzed individuals were documented as having succumbed to malignant neoplastic disease, a total of 37.4% (n = 49) of the individuals did not exhibit osseous abnormalities. Individuals with breast cancer often exhibited lesions. This study presents a quantitative estimate of the accuracy of paleopathological diagnosis; as well as a theoretical reflection on the burden of cancer in the past. We emphasize the need for a paradigm shift while thinking about the future of paleo-oncology.

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Section: Interpretation Of the Score 2 Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Absence of evidence or evidence of absence? A discussion on paleoepidemiology of neoplasms with contributions from two Portuguese human skeletal reference collections (19th–20th century)

Marques

Matos

Costa

et al. 2018

International Journal of Paleopathology

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PET/CT in assessment of colorectal liver metastases: a comprehensive review with emphasis on 18F-FDG

Zirakchian Zadeh

2023

Clin Exp Metastasis

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Pattern of Metastatic Bone Disease- An Observational Study

Krishnan¹,

Shetty²,

Babu³

et al. 2018

jemds

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BACKGROUND Metastasis to the skeletal system is commonly associated with lung, prostate and breast cancers. The pattern of metastatic spread varies depending on the type of the primary tumour and its site. This study aimed to assess the pattern and anatomical distribution of skeletal metastases in histologically proven malignancies. MATERIALS & METHODS 128 consecutive cancer patients with evidence of skeletal metastasis were evaluated for the anatomical distribution of bone metastases. The clinical presentation of the metastatic bone disease was documented and the pattern of skeletal metastasis in various cancers evaluated. RESULTS The 128 patients (76 males and 52 females) consisted of 45 patients (35.2%) with lung cancer, 41 patients (32%) with prostate cancer, 19 patients (14.8%) with breast cancer, 9 patients (7%) with gastrointestinal cancer, 7 patients (5.5%) with renal cell carcinoma and other miscellaneous tumours in the remaining 7. Spine was found to be the most common site of skeletal metastasis (57.8%), followed by pelvic bones (22.6%) and ribs (14.8%). Lung cancers metastasized to spine, pelvis, ribs, scapula, humerus and sternum. Prostate and breast cancers had metastatic lesions in the spine, pelvis, ribs, scapula, femur, sternum, clavicle, and tibia. The clinical presentation varied from no specific symptoms to bone pain, neurological deficit and pathological fracture. CONCLUSION Bone metastasis has been found to occur in a predictable pattern. Thus, the knowledge of the usual pattern of metastasis in the commonly seen malignancies will enable the clinician to formulate a thorough work-up for the diagnosis and management of metastatic bone disease.

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Diagnosis of Skeletal Metastases in Malignant Extraskeletal Cancers

Cited by 3 publications

References 30 publications

Absence of evidence or evidence of absence? A discussion on paleoepidemiology of neoplasms with contributions from two Portuguese human skeletal reference collections (19th–20th century)

Absence of evidence or evidence of absence? A discussion on paleoepidemiology of neoplasms with contributions from two Portuguese human skeletal reference collections (19th–20th century)

PET/CT in assessment of colorectal liver metastases: a comprehensive review with emphasis on 18F-FDG

Pattern of Metastatic Bone Disease- An Observational Study

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