Diagnosis of right ventricular acute myocardial infarction by dual isotope thallium-201 and indium-111 antimyosin SPECT imaging

Rational chemical design of the next generation of molecular imaging probes based on physics and biology: mixing modalities, colors and signals

“…158,159,167,168 Multiple color optical agents can be combined with multiple multimodality imaging. 33,[169][170][171][172] B.2.2 Nuclear ''multi-color'' imaging. Using energy resolution features of gamma cameras and different types of gamma emitters, multiple nuclear probes can be detected simultaneously, each targeting a different process.…”

“…Clinical applications include SPECT for thyroid and parathyroid imaging in which radioactive iodine and thallium are used together 173,174 as well as in cardiac scintigraphy where radioactive technetium and thallium may be combined. [169][170][171] For instance, in the assessment of acute myocardial ischemia 201 Tl is used to identify areas with patent blood flow and 99m Tc-labelled myosin antibody-fragment is used to identify areas of damaged myocardium by detection of exposed myosin fibers. 170,171 Although multiplexed nuclear imaging provides useful insights, broader application has been limited by the poor spatial resolution of SPECT and the double dose of ionizing radiation required.…”

“…[169][170][171] For instance, in the assessment of acute myocardial ischemia 201 Tl is used to identify areas with patent blood flow and 99m Tc-labelled myosin antibody-fragment is used to identify areas of damaged myocardium by detection of exposed myosin fibers. 170,171 Although multiplexed nuclear imaging provides useful insights, broader application has been limited by the poor spatial resolution of SPECT and the double dose of ionizing radiation required. Additionally, current strategies for imaging with multiple radiolabelled antibodies require several days from the time of administration for sufficient TBR.…”

Multiplexed imaging in cancer diagnosis: applications and future advances

“…One approach to increase the information is to use multiplex imaging with an additional imaging agent. Multi contrast agent applications include SPECT in the thyroidandparathyroid 17–19 and cardiac scintigraphy, 20–23,48–51 both of which can simultaneously detect two different imaging agents (ie, 99m Tc, 123 I, 111 In, and 201 Tl) with the energy resolution features of gamma cameras (figure 1B). These methods rely on the use of two different agents, each targeting a different process, and simultaneously acquiring data from each.…”

“…Clinical applications include the assessment of acute cardiac ischaemia with 201 Tl to identify viable myocardium through patent blood flow in combination with 111 In-labelled myosin antibody to identify exposed myosin fibres in damaged myocardium. 20–23 Although promising, these advances have limited spatial resolution and do not allow the recon struction of high-resolution images, as can be achieved using conventional methods. Unfortunately, imaging with multiple radiolabelled antibodies faces similar challenges.…”