Diagnosis of pulmonary tuberculosis from gastric aspirate samples in nonexpectorating pediatric patients in a tertiary care hospital

Sharma, S. N.; Shulania, Anuradha; Achra, Arvind; Jeram, Hishmi; Kansra, Stuti; Duggal, Nandini

doi:10.4103/ijpm.ijpm_694_19

Cited by 8 publications

(4 citation statements)

References 8 publications

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“…In this study, the diagnostic yield for microscopy, MGIT960, and CBNAAT were 8.57%, 22.9%, and 21.4% respectively for GA samples and the diagnostic yield for microscopy, MGIT960, and CBNAAT were 2.9%, 15.7%, and 12.9% respectively for IS samples. Sharma S et al [5] in their study found that GA samples provide better diagnostic yield for the detection of paediatric pulmonary TB than IS samples. The findings show that diagnostic yield for different diagnostic modalities varies in different studies.…”

Section: Discussionmentioning

confidence: 92%

“…The diagnostic performance of Xpert is comparable in IS and GA specimens. Depending on the sensitivity of the laboratory test used, GA samples have been found to have the highest detection rate (40-92%), whereas IS provides detection rates of 20-30% [5].…”

Section: Discussionmentioning

confidence: 99%

“…An automated liquid culture device for mycobacterial identification is the BD BACTEC™ Mycobacteria Growth Indicator Tube (MGIT™) system (Becton Dickinson, Buenos Aires, Argentina). Compared to traditional solid culture on the Lowenstein-Jensen (LJ) medium, it is created and optimized for the quick identification of mycobacteria from clinical specimens [5].…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic Utility of Cartridge-Based Nucleic Acid Amplification Test (CBNAAT) on Induced Sputum Versus Gastric Aspirate Samples for the Diagnosis of Paediatric Pulmonary Tuberculosis

Mishra,

Singh,

Yadav

et al. 2023

Cureus

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Background: Tuberculosis (TB) in children is neglected, mainly due to a lack of sensitive diagnostic tools. Paediatric TB is now a global priority. More paediatric TB cases are being recorded as a result of the introduction of Xpert® Mycobacterium tuberculosis (MTB)/rifampicin (RIF) (Cepheid Inc., Sunnyvale, USA). This study was undertaken to evaluate the performance of Xpert MTB/RIF in the diagnosis of pulmonary TB in children.Methods: We recruited 70 paediatric patients with probable pulmonary TB and their gastric aspirate (GA), and induced sputum (IS) samples were collected between January 2021 and June 2022 in Saifai, Etawah, Uttar Pradesh, at the Microbiology Department of the Uttar Pradesh University of Medical Sciences (U.P.U.M.S.). All samples were subjected to smear examination, Bacterial Activation of Continuous Temperature and Environmental Control -Mycobacterial Growth Indicator Tube (BACTEC-MGIT) culture, and Xpert MTB/RIF.Results: The specimens included 70 GAs and 70 IS samples. The total number of specimens were 140 and we collected GA as well as IS from each of the patient enrolled in the study. When compared to microscopy, GeneXpert provides a quicker and earlier detection of paediatric TB. The sensitivity of the cartridge-based nucleic acid amplification test (CBNAAT) against mycobacterial growth indicator tube (MGIT) was 75.0% for GA samples and 63.64% for IS samples. Conclusion: Paediatric TB, owing to its paucibacillary nature and difficulty in the collection of samples, makes the diagnosis difficult by conventional methods. Our study shows that smear and culture yield in GA samples are superior to those of IS samples and the sensitivity of Xpert MTB/RIF assay is also significantly different in GA and IS samples, but a combination of GA and IS yielded the best results.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Diagnostic Utility of Cartridge-Based Nucleic Acid Amplification Test (CBNAAT) on Induced Sputum Versus Gastric Aspirate Samples for the Diagnosis of Paediatric Pulmonary Tuberculosis

Mishra,

Singh,

Yadav

et al. 2023

Cureus

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“…S dan Ny. M dengan masalah keperawatan defisit pengetahuan di Kelurahan Bintoro dilakukan dengan beberapa cara yakni mengidentifikasi faktor penyebab TBC, mengajarkan perilaku hidup bersih dan sehat, serta melakukan penyuluhan tentang TBC (Nishiguchi, 2018;Sharma, 2020).…”

Section: Implementasiunclassified

Asuhan Keperawatan Keluarga pada Kasus Tuberculosis Paru dengan Kurangnya Pengetahuan Keluarga Merawat Anggota Keluarga yang Sakit Wilayah Kerja Puskesmas Banjarsengon

Wijaya,

Zaini

2023

phms

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Tuberculosis adalah penyakit menular disebabkan oleh infeksi bakteri Mycobacterium tuberculosis.Penularan ini dapat melaui droplet pada orang yang terinfeksi kuman Mycobacterium tuberculosis, penyakit tuberculosis dapat menular secara luas dan cepat (Depkes RI, 2017). Sumber penularan adalah penderita tuberkulosis paru BTA (+) yang bisa menularkan kepada orang di sekelilingnya, terutama menularkan pada seseorang yang kontak erat. Bakteri ini tidak tahan terhadap cahaya terutama sinar matahari sehingga perkembangan bakteri yang cepat terjadi pada malam hari (Rab, 208 C.E.). Tuberculosis masih menjadi masalah kesehatan di dunia terutama di negara berkembang. Bagi orang terjangkit tuberkulosis, ada satu hal penting yang wajib diperhatikan dan dilakukan, yaitu keteraturan dalam meminum Obat Anti Tuberkulosis (OAT) sampai dinyatakan sembuh. Biasanya penderita mengonsumsi OAT tersebut dengan jangka waktu 6 – 8 bulan. Metode penulisan dengan model studi kasus dengan pendekatan deskriptif analitik pada Tn. S dan Ny. M di Kelurahan Bintoro Wilayah Kerja PUSKESMAS Banjarsengon. Hasil studi kasus ini adalah Evaluasi asuhan keperawatan keluarga pada Tn. S dan Ny. M dengan masalah keperawatan defisit pengetahuan di Kelurahan Bintoro dapat dilakukan dengan baik. Diharapkan setelah diberikan tindakan keperawatan keluarga Tn.S dan Ny.M dapat merawat anggota keluarga dengan tepat.

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Advances in Mycobacterial Laboratories: What Is the Latest Laboratory Approach to Diagnose and Manage Pulmonary TB?

Mitarai

2022

Respiratory Disease Series: Diagnostic Tools and Disease Managements

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Diagnosis of pulmonary tuberculosis from gastric aspirate samples in nonexpectorating pediatric patients in a tertiary care hospital

Cited by 8 publications

References 8 publications

Diagnostic Utility of Cartridge-Based Nucleic Acid Amplification Test (CBNAAT) on Induced Sputum Versus Gastric Aspirate Samples for the Diagnosis of Paediatric Pulmonary Tuberculosis

Diagnostic Utility of Cartridge-Based Nucleic Acid Amplification Test (CBNAAT) on Induced Sputum Versus Gastric Aspirate Samples for the Diagnosis of Paediatric Pulmonary Tuberculosis

Asuhan Keperawatan Keluarga pada Kasus Tuberculosis Paru dengan Kurangnya Pengetahuan Keluarga Merawat Anggota Keluarga yang Sakit Wilayah Kerja Puskesmas Banjarsengon

Advances in Mycobacterial Laboratories: What Is the Latest Laboratory Approach to Diagnose and Manage Pulmonary TB?

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