Diagnosis of Primary Langerhans Cell Histiocytosis of the Vulva in a Postmenopausal Woman

Abstract

Langerhans cell histiocytosis (LCH) is a very rare disease of female genital tract, most commonly seen in vulva and unusual in postmenopausal period. Herein, we report the 8th case of pure vulvar LCH in a postmenopausal woman. We pay attention to the differential diagnosis in postmenopausal state, features of pathologic diagnosis, and treatment options.

Vulvar Langerhans cell histiocytosis and thalidomide: an effective treatment option

“…Involvement of the genital area usually occurs as part of a multisystem disease and only infrequently as an isolated phenomenon . To 2015, a total of 26 cases of pure vulva involvement had been published, in which the most frequent location was the female genital tract …”