Diagnosis of pheochromocytoma using [¹²³I]‐ compared with [¹³¹I]‐metaiodobenzylguanidine scintigraphy

Abstract

Background: Patient with pheochromocytoma (PCT) cannot be cured without operation, therefore, preoperative determination of the localization of PCT should be performed accurately.

Diagnostic Performance of 68Ga-DOTATATE PET/CT, 18F-FDG PET/CT and 131I-MIBG Scintigraphy in Mapping Metastatic Pheochromocytoma and Paraganglioma

“…Despite comparable results of I-MIBG scintigraphy in PCC/PGL detection [34], the lower sensitivity of 131 I-MIBG scintigraphy observed in this study could still be 18 F-FDG PET/CT was considered true positive, the specificities of all three modalities are thus, by definition, 100 % I for imaging with current gamma cameras, which contribute to poorer target-to-background ratio, and therefore possibly lower detection rate. Other factors, such as different biological properties among patients or presence of MIBGconfounding therapy, may also contribute to these discrepancies.…”

A Case of Metastatic Extra-Adrenal Pheochromocytoma 12 Years after Surgery

“…However, the sensitivity of CT for extra-adrenal pheochromocytoma is lower than that for adrenal pheochromocytoma (82% vs. 94%) (11). The sensitivity and specificity of MIBG scintigraphy is reported to be 87.4% and 99%, respectively (19). MIBG scintigraphy is the most valuable tool in detection of extra-adrenal pheochromocytoma and its metastases, especially when CT and MRI findings are negative.…”

Semiquantitative 123I-Metaiodobenzylguanidine Scintigraphy to Distinguish Pheochromocytoma and Paraganglioma from Physiologic Adrenal Uptake and Its Correlation with Genotype-Dependent Expression of Catecholamine Transporters

“…For example, several studies demonstrated a poor overall sensitivity of 123 I-MIBG scintigraphy in SDHB-related PPGLs (,50%) (24,25). Similar to 123 I-MIBG, several PET tracers specifically target catecholamine synthesis, storage, and secretion pathways including 18 F-fluorodihydroxyphenylalanine and 18 F-fluorodopamine. Kaji et al showed that 18 F-fluorodihydroxyphenylalanine PET is superior to 123 I-MIBG scintigraphy in the context of von HippelLindau syndrome (26).…”

“…Overall, specificities of 123 I-MIBG scintigraphy range between 70% and 100% for pheochromocytomas and 84% and 100% for paragangliomas, whereas sensitivities range between 85% and 88% and 56% and 76%, respectively (14)(15)(16)(17). Physiologic uptake of 123 I-MIBG by normal adrenal glands can give false-positive results or obscure small lesions (18)(19)(20). The sensitivity appears to be lower for extraadrenal, metastatic, recurrent, and certain hereditary PPGLs (14,16,(21)(22)(23)(24).…”