Diagnosis of oral mucous membrane pemphigoid by means of combined serologic testing

Hayakawa, Taihei; Furumura, Minao; Fukano, Hideo; Li, Xiaoguang; Ishii, Norito; Hamada, Takahiro; Ohata, Chika; Tsuruta, Daisuke; Shimozato, Kazuo; Hashimoto, Takashi

doi:10.1016/j.oooo.2013.12.402

Cited by 62 publications

(110 citation statements)

References 53 publications

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“…La pemphigoide cicatricielle est une dermatose bulleuse auto-immune sous épidermique rare [1]. Elle est plus fréquente chez la femme (sexe ratio F/H de 1.5 à 2) [3].…”

Section: Discussionunclassified

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Forme particulière de Pemphigoide cicatricielle à dépôt unique d’IgA

Aounallah¹,

Jrad²,

Ksiaa³

et al. 2017

Pan Afr Med J

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La Pemphigoide cicatricielle est une dermatose bulleuse sous épithéliale qui atteint essentiellement les muqueuses avec une évolution cicatricielle. Il s'agit d'un homme de 66 ans hospitalisé pour gingivite érosive avec dysphagie, dyspnée et flou visuel. L'examen dermatologique retrouvait des lésions érosives du palais et du pharynx. L'examen ophtalmologique notait des symblépharons, un ectropion et une cataracte bilatérale. La biopsie gingivale avait montré un décollement nécrotique de l'épithélium buccal. L'immunofluorescence directe notait un dépôt linéaire d'Immunoglobuline A à la jonction dermo-épidermique. L'Immunofluorescence indirecte était revenue négative. Le diagnostic de pemphigoide cicatricielle était confirmé. Le Transit oeso-gastro-duodénal a objectivé une double sténose de l'œsophage. L'endoscopie nasale, pharyngée et bronchique retrouvait des ulcérations de l'épiglotte, de l'hypopharynx, du pharynx et de l'arbre bronchique. Le patient a bénéficié d'un bolus de Solumedrol relayé par la Prednisone à la dose de 0.5mg/Kg/j associé à la Disulone à la dose de 100mg/j. L'évolution était favorable au début mais s'est compliquée après 2 mois d'une aggravation de la dysphagie et de la sténose oesophagienne. Notre observation est très particulière par la survenue d'une Pemphigoide cicatricielle chez un sujet de sexe masculin ayant un tableau grave en rapport avec l'extension des lésions à toutes les muqueuses conjonctivale, buccale, nasale, œsophagienne et même bronchique associée à une immunofluorescence directe faite d'un dépôt d'IgA uniquement.

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“…La pemphigoide cicatricielle est une dermatose bulleuse auto-immune sous épidermique rare [1]. Elle est plus fréquente chez la femme (sexe ratio F/H de 1.5 à 2) [3].…”

Section: Discussionunclassified

“…La pemphigoide cicatricielle est une dermatose bulleuse sous-épithéliale auto-immune rare [1]. Elle se caractérise par une atteinte essentiellement muqueuse notamment la muqueuse buccale, conjonctivale, oropharyngée, oesophagienne [2] avec une évolution cicatricielle des lésions ce qui fait toute la gravité de l'atteinte.…”

Section: Introductionunclassified

Forme particulière de Pemphigoide cicatricielle à dépôt unique d’IgA

Aounallah¹,

Jrad²,

Ksiaa³

et al. 2017

Pan Afr Med J

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“…In order to identify the final target antigen, immunoblotting using the C‐terminal of BP180 and laminin‐332 recombinant proteins is necessary, but facilities in which the procedure can be performed are limited. ELISA (CLEIA) of the NC16a domain of BP180 tests positive in more than half of cases of anti‐BP180 type MMP; however, even in negative cases, the possibility of MMP cannot be ruled out . Recently, an ELISA method using BP180 full‐length recombinant protein has been developed, and it is expected to be clinically applied for the diagnosis of anti‐BP180 type MMP and the evaluation of disease activity …”

Section: Overview Of Pemphigoid Diseasesmentioning

confidence: 99%

Japanese guidelines for the management of pemphigoid (including epidermolysis bullosa acquisita)

Ujiie

Iwata

Yamagami

et al. 2019

The Journal of Dermatology

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The pemphigoid group is a category of autoimmune subepidermal blistering diseases in which autoantibodies deposit linearly at the epidermal basement membrane zone (BMZ). The main subtypes of pemphigoid mediated by immunoglobulin G autoantibodies are bullous pemphigoid (BP), mucous membrane pemphigoid (MMP) and epidermolysis bullosa acquisita (EBA). To establish the first guidelines approved by the Japanese Dermatological Association for the management of pemphigoid diseases, the Committee for Guidelines for the Management of Pemphigoid Diseases (Including EBA) was founded as part of the Study Group for Rare Intractable Skin Diseases under the Ministry of Health, Labor and Welfare Research Project on Overcoming Intractable Diseases. These guidelines aim to provide current information for the management of BP, MMP and EBA in Japan. Based on evidence, the guidelines summarize the clinical and immunological manifestations, pathophysiologies, diagnostic criteria, disease severity determination criteria, treatment algorithms and treatment recommendations. Because of the rarity of these diseases, there are few clinical studies with a high degree of evidence, so several parts of these guidelines were established based on the opinions of the Committee. To further optimize these guidelines, periodic revision in line with the new evidence is necessary.

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“…A way to detect the proteins present in MMP is by using the western blot or immunoblotting technique. This method uses antibodies to detect the target proteins present in each serum [29]. The fourth method ELISA, is another technique that can provide serum samples with immunopathological data.…”

Section: Diagnosis Techniques and Correlating Symptomsmentioning

confidence: 99%

“…There are continuous findings that provide new diagnostic tools or new treatment procedures. There have been new discoveries that involve combined serologic testing to diagnose MMP as well as indirect immunofluorescence (IIF), which has been exceptionally helpful in diagnosing MMP [29]. Of the new tools that have been discovered to assist in diagnosing, one example is reflectance confocal microscopy (RCM).…”

Section: Recent Advancements and Treatmentsmentioning

confidence: 99%

Mucous membrane pemphigoid: A wide-ranging assessment of various cases and corresponding methods of diagnosis and treatment

Sivri¹,

Chandra²

2018

Med-Science

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Mucous Membrane Pemphigoid (MMP) is as an infrequent yet tenacious autoimmune blistering disease involving the mucosae of the oral cavity, as well as the conjunctiva, genitals, nasal cavity, pharynx and occasionally the skin. It is seen most commonly in older adults, although cases have been reported throughout early childhood. This review article will provide a thorough explanation of MMP by discussing common misdiagnosis scenarios, presenting rare case reports, and exploring recent treatment options in hopes of spreading awareness for furthering research on diagnosis techniques. The purpose this article is to bring light to the dental community, medical professionals and autoimmune disease researchers, the importance of an early and authentic diagnosis and corresponding methods of recent treatments.

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Diagnosis of oral mucous membrane pemphigoid by means of combined serologic testing

Cited by 62 publications

References 53 publications

Forme particulière de Pemphigoide cicatricielle à dépôt unique d’IgA

Forme particulière de Pemphigoide cicatricielle à dépôt unique d’IgA

Japanese guidelines for the management of pemphigoid (including epidermolysis bullosa acquisita)

Mucous membrane pemphigoid: A wide-ranging assessment of various cases and corresponding methods of diagnosis and treatment

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