Diagnosis of ocular toxocariasis by detecting antibodies in the vitreous humor

Inchauspe, Sebastian; Echandi, Laura V.; Dodds, Emilio M.

doi:10.1016/j.oftale.2018.02.004

Cited by 5 publications

(5 citation statements)

References 30 publications

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“…27 Inchauspe et al reported six OT cases with negative serological antitoxocara IgG subsequently confirmed by positive vitreous anti-toxocara IgG. 17 To our knowledge, our study was the first to focus on the cutoff value of IF antitoxocara IgG. We found that IF anti-toxocara IgG is an even better diagnostic tool for OT than serum antitoxocara IgG.…”

Section: Discussionsupporting

confidence: 45%

“…15 On the other hand, even if serological toxocara antibody is negative, diagnosis of OT cannot be excluded. [16][17][18][19] Therefore, the detection of anti-toxocara IgG in the intraocular fluid (IF) has been suggested to confirm the diagnosis. 17 However, to date, a diagnostic cutoff value for IF anti-toxocara IgG has not been reported, and the diagnostic value of the Goldmann-Witmer coefficient (GWC) remains uncertain.…”

Section: Introductionmentioning

confidence: 99%

“…[16][17][18][19] Therefore, the detection of anti-toxocara IgG in the intraocular fluid (IF) has been suggested to confirm the diagnosis. 17 However, to date, a diagnostic cutoff value for IF anti-toxocara IgG has not been reported, and the diagnostic value of the Goldmann-Witmer coefficient (GWC) remains uncertain. For a more objective and precise diagnosis of OT, in this study, we detected the level of specific toxocara antibodies in serum and in IF, to further analyze their diagnostic value.…”

Section: Introductionmentioning

confidence: 99%

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Diagnosis of Ocular Toxocariasis by Serum and Aqueous Humor IgG ELISA

Huang

Sun

Liu

et al. 2021

Trans. Vis. Sci. Tech.

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Ocular toxocariasis (OT) is a worldwide ocular parasitic infection and is especially sight-threatening in children. Because of the clinical manifestation diversity, OT has frequently been misdiagnosed. The purpose of this study was to evaluate the diagnostic value of anti-toxocara immunoglobulin G (IgG) in intraocular fluid (IF) and serum in OT.Methods: IF and serum were collected from patients with clinically diagnosed OT and non-OT uveitis. The level of anti-toxocara IgG was detected by enzyme-linked immunosorbent assay. The data were statistically analyzed in anti-toxocara IgG and the Goldmann-Witmer coefficient (GWC) between groups. The area under the receiver operating characteristic curve (AUC ROC) was performed to assess the diagnostic value of serum and IF anti-toxocara IgG and the GWC.Results: A total of 290 participants, 128 (44.1%) with OT and 162 (55.9%) with non-OT uveitis, were included in this study. The default serum anti-toxocara IgG cutoff value of 11 U had 72.1% sensitivity and 95.5% specificity. With the optimized cutoff value of 8.2 U, the AUC was 0.886 (95% confidence interval [CI] = 0.830-0.929, P < 0.0001), sensitivity increased to 80.2%, and specificity was 94.0%. With an IF anti-toxocara IgG cutoff value of 1.8 U, the AUC was 0.934 (95% CI = 0.892-0.963, P < 0.0001), sensitivity was as high as 88.4%, and specificity was 96.4%. Conclusions:Our study proposes novel diagnostic cutoff values of serum and IF antitoxocara IgG for OT, which are 8.2 U and 1.8 U, respectively.

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Section: Discussionsupporting

confidence: 45%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Diagnosis of Ocular Toxocariasis by Serum and Aqueous Humor IgG ELISA

Huang

Sun

Liu

et al. 2021

Trans. Vis. Sci. Tech.

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“…9 OT is mostly unilateral (90%) and affects children and young adults. [10][11][12] The contamination occurs through contact with dogs and cats, especially puppies and kittens or soil. OT manifests with unilateral blurry vision, floaters, strabismus and leukocoria in more advanced cases.…”

Section: Discussionmentioning

confidence: 99%

Late onset retinoblastoma in a 12-year-old girl: a case report

Lazari

Papageorgiou

Tsironi

et al. 2022

Preprint

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We report the case of a 12-year-old girl, who presented with floaters and a white-to-cream peripheral retinal mass in her left eye. No intrinsic calcifications in B-scan ultrasonography and CT scan of the orbits were present and MRI showed a homogenously enhancing peripheral retinal mass with restricted diffusion. Due to close contact with puppies, the patient was initially treated for ocular toxocariasis. However, one month later she developed anterior chamber seeding and anterior chamber tap showed group E retinoblastoma (RB). This case underlines that RB may occur in older ages with atypical manifestations, such as uveitis and absence of calcifications.

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“…The initial diagnosis of OLM is based on clinical signs and observation of lesions with an ophthalmoscope in the fundus examination. Confirmation of the diagnosis can be made by the detection of antibodies against excretion-secretion antigens of T. c a n i s by ELISA in the vitreous humor of the affected eye and the study of the lesions by ultrasound biomicroscopy (UBM) and optical coherence tomography (OCT) [71,72].…”

Section: Olm Syndromementioning

confidence: 99%

Toxocariosis: From a One Health Perspective

Arenzana-Seisdedos¹,

Muñoz-Guzmán²

2022

Parasitic Helminths and Zoonoses - From Basic to Applied Research

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Toxocariosis is a neglected zoonotic infection caused by the nematodes Toxocara canis or Toxocara cati. The distribution of the disease is worldwide and mainly affects dogs and cats, and its larval stage can cause human infection with serious repercussions on the health of its hosts. The infection causes a delay in the development, digestive disorders, nonspecific nervous manifestations, and occasionally death of some puppies and kittens associated with hyperparasitosis. In humans, the infection produces clinical syndromes known as visceral larva migrans (VLM), ocular larva migrans (OLM), neurotoxocariosis and covert toxocariosis. The close contact of people with their pets and the environmental conditions that favor the transmission of this diseased place it within the context of one health. The One Health concept is defined as the collaborative efforts of multiple disciplines (medical personnel, veterinarians, researchers, etc.) that work locally, nationally, and globally to achieve optimal health for people, animals, and the environment, from this perspective, toxocariosis is a study model in which classic and recent knowledge of the medical and veterinary area must be combined for its full understanding, with a goal of establishing integrative criteria for its treatment, control, and prevention.

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Diagnosis of ocular toxocariasis by detecting antibodies in the vitreous humor

Cited by 5 publications

References 30 publications

Diagnosis of Ocular Toxocariasis by Serum and Aqueous Humor IgG ELISA

Diagnosis of Ocular Toxocariasis by Serum and Aqueous Humor IgG ELISA

Late onset retinoblastoma in a 12-year-old girl: a case report

Toxocariosis: From a One Health Perspective

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