Diagnosis of Myeloproliferative Disease by Analysis of the Platelet Volume Distribution

Small, Bruce M.; Bettigole, Richard E.

doi:10.1093/ajcp/76.5.685

Cited by 29 publications

(11 citation statements)

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“…Increased MPV and heterogeneity in platelet volume and mass were associated with decreased platelet density in this study. These findings are in agreement with those from early studies using platelet morphology in blood smears or other Hematology analyzers [21][22][23][24]. The increase in platelet volume and the decrease in platelet buoyant density that we observed could be explained by proliferation or dilation of the dense tubular and open canalicular system and reduction of the mitochondria, dense granules, and -granules, as found in ultrastructural studies of platelets from ET patients [25][26][27][28].…”

Section: Discussionsupporting

confidence: 93%

Automated assessment of the neutrophil and platelet activation status in patients with essential thrombocythemia

et al. 2011

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Neutrophil and platelet activation are consistently found in essential thrombocythemia (ET), but the techniques employed to demonstrate such abnormalities are complex. To ascertain whether the ADVIA 120 analyzer can be employed to assess neutrophil and platelet activation status in ET, 55 such patients and the same number of matched healthy individuals were studied and the results correlated with neutrophil CD11b and platelet P-selectin expressions measured by flow cytometry. Compared with controls, ET patients had significantly higher values of neutrophil myeloperoxidase index (MPXI), mean platelet volume (MPV), platelet distribution width (PDW), and platelet component distribution width, and significantly lower values of neutrophil lobularity index and mean platelet component (MPC). Patients with the JAK2 mutation had significantly lower values of MPC and higher values of MPV and PDW than those with wild-type allele. A positive correlation was observed between MPXI and neutrophil CD11b expression and a negative correlation between MPC and platelet P-selectin expression. The intensity of the agreement between the variables obtained by the two methods was moderate. These results support the possible value of MPC as surrogate parameter of platelet activation in ET.

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Section: Discussionsupporting

confidence: 93%

Automated assessment of the neutrophil and platelet activation status in patients with essential thrombocythemia

et al. 2011

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“…But the values of the six parameters obtained in the controls were independent of sex and age. Other studies have shown that platelet volume is not influenced by sex and age [2,9,20,21]. Our results also show that the incidence of a peak of small elements giving the curve a bimodal aspect, was not significantly dif ferent between CT and PT patients.…”

Section: Discussionsupporting

confidence: 65%

“…Nevertheless, the anticoagu lant used for blood collection must be the same since it is well known that EDTA in duces a swelling of platelets in the two first hours after blood collection [8,12,21], So the median which takes into account MPV as well as PDW (which is a good index of platelet heterogeneity [3]) seems to be very representative of the whole blood popula tion and deserves to be tested in other pa thologies where platelets are affected.…”

Section: Discussionmentioning

confidence: 99%

Discriminant Study of Platelet Volume Indices in the Etiological Diagnosis of Thrombocytopenia

et al. 1984

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Platelet volume distribution was examined in 47 thrombocytopenic subjects with a platelet count between 20 10⁹ and 150 10⁹/1. Thrombocytopenia was attributed to defective production in 19 cases (12 acute leukemia) and to accelerated destruction in 28 cases (27 idiopathic thrombocytopenic purpura). Six volume variables were retained from the platelet volume distribution curves. A multivariate discriminant analysis has shown that the median of the curves was the most discriminant parameter between the two types of thrombocytopenia: the value of the median was less than 7 μm³ in 89.5% of patients with defective platelet production and greater than 7 μm³ in 85.7% of those with excessive platelet destruction. Thus, platelet volume measurement and the median value in particular allows a rapid orientation of the etiological diagnosis of thrombocytopenia.

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“…Moreover, the available means to differentiate these two entities are not specific enough. Some authors tried to distinguish thrombocytosis in ET from reactive thrombocytosis by using PLT parameters provided by blood analyzers [7, 8]. …”

Section: Discussionmentioning

confidence: 99%

Does Thrombocyte Size Give Us an Idea about Thrombocytosis Etiology?

Toprak

Erismis

Karakuş

et al. 2012

The Scientific World Journal

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In the presence of a pathogenetic mutation in JAK2 or MPL, a differential diagnosis of essential thrombocythemia (ET) from reactive causes is relatively simple. However, in patients with suspected ET who lack JAK2 and MPL mutations, the exclusion of secondary causes is especially important. The study was aimed to explore the clinical application of particularly mean platelet volume (MPV), hemoglobin, red blood cell indices, white blood cell, serum iron profile, and C-reactive protein level in the differential diagnosis of thrombocytosis. Medical records of 49 patients, consisting of reactive thrombocytosis (RT) and ET were retrospectively reviewed. The mean MPV level in RT group was 7.49 fL, and in ET group was 8.80 fL (P < 0.01). A cutoff point of <8.33 fL was found to have significant predictive value according to ROC curve analysis. This cutoff was associated with 83% positive predictive value (PPV) and 74% negative predictive value (NPV) in the diagnosis of ET and had a sensitivity of 65% and specificity of 89% for ET. Investigation of MPV is cheap, quick, and noninvasive, and may serve as a predictor of primary thrombocytosis. High sensitivity, specificity, PPV, and NPV enable this test an important tool and a possible surrogate marker in clinical practice.

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Diagnosis of Myeloproliferative Disease by Analysis of the Platelet Volume Distribution

Cited by 29 publications

References 0 publications

Automated assessment of the neutrophil and platelet activation status in patients with essential thrombocythemia

Automated assessment of the neutrophil and platelet activation status in patients with essential thrombocythemia

Discriminant Study of Platelet Volume Indices in the Etiological Diagnosis of Thrombocytopenia

Does Thrombocyte Size Give Us an Idea about Thrombocytosis Etiology?

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