Diagnosis of Mesobuthus eupeus envenomation by skin test: Reverse passive Arthus reaction

Khoobdel, Mehdi; NikbakhtBoroujeni, Gh; Zahraei-Salehi, Taghi; Khosravi, Mohammad; Sasani, Farhang; Bokaei, S; Koochakzadeh, Alireza; Zamani‐Ahmadmahmudi, Mohamad; Akbari, Abolfazl

doi:10.1016/j.toxicon.2013.11.004

Cited by 1 publication

(1 citation statement)

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“…According to the authors, the simplicity of application, low cost, minimal risk, suitable specificity, sensitivity and quick visible results indicated the possibility of using this reaction in envenomation diagnosis. However, despite satisfactory results, more research is required to prove and reduce probable side effects before it is tested in humans [ 42 ].…”

Section: In Vitro Assays For Identification And/or Quantification mentioning

confidence: 99%

Venomous Arachnid Diagnostic Assays, Lessons from Past Attempts

Dias-Lopes

Paiva

Guerra-Duarte

et al. 2018

Toxins

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Diagnostic tests for arachnid accidents remain unavailable for patients and clinicians. Together with snakes, these accidents are still a global medical concern, and are recognized as neglected tropical issues. Due to arachnid toxins’ fast mechanism of action, quick detection and quantification of venom is required to accelerate treatment decisions, rationalize therapy, and reduce costs and patient risks. This review aims to understand the current limitations for arachnid venom identification and quantification in biological samples. We benchmarked the already existing initiatives regarding test requirements (sample or biomarkers of choice), performances (time, detection limit, sensitivity and specificity) and their validation (on animal models or on samples from envenomed humans). Our analysis outlines unmet needs for improving diagnosis and consequently treatment of arachnid accidents. Hence, based on lessons from past attempts, we propose a road map for raising best practice guidelines, leading to recommendations for future progress in the development of arachnid diagnostic assays.

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Section: In Vitro Assays For Identification And/or Quantification mentioning

confidence: 99%