Diagnosis of MALT Lymphoma from Surveillance Endoscopy of a Patient with a &lt;b&gt;&lt;i&gt;CDH1&lt;/i&gt;&lt;/b&gt; Gene Germline Mutation

Pinto, Cláudia Martins Marques; Cunha, Ana Luísa; Rodrigues, Ângelo; Dias, Rita; Brandão, Catarina; Dinis-Ribeiro, Mário

doi:10.1159/000514652

Cited by 1 publication

(1 citation statement)

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“…This raises the question of the necessity of these biopsies, which should always be encouraged in patients undergoing upper endoscopy for any reason. In a number of patients, GML is diagnosed histologically on systematic biopsies obtained on a normally looking or showing only slight abnormalities gastric mucosa [27,33,34]. In an analysis of pooled data regarding 2000 patients included in 38 studies published before 2010, GML was diagnosed on a normal or slightly hyperemic gastric mucosa in 140 patients (8.4%) [35].…”

Section: Endoscopymentioning

confidence: 99%

Clinical Management of Patients with Gastric MALT Lymphoma: A Gastroenterologist’s Point of View

Matysiak‐Budnik

Priadko

Bossard³

et al. 2023

Cancers

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Gastric mucosa-associated lymphoid tissue (MALT) lymphomas (GML) are non-Hodgkin lymphomas arising from the marginal zone of the lymphoid tissue of the stomach. They are usually induced by chronic infection with Helicobacter pylori (H. pylori); however, H. pylori-negative GML is of increasing incidence. The diagnosis of GML is based on histological examination of gastric biopsies, but the role of upper endoscopy is crucial since it is the first step in the diagnostic process and, with currently available novel endoscopic techniques, may even allow an in vivo diagnosis of GML per se. The treatment of GML, which is usually localized, always includes the eradication of H. pylori, which should be performed even in H. pylori-negative GML. In the case of GML persistence after eradication of the bacteria, low-dose radiotherapy may be proposed, while systemic treatments (immunochemotherapy) should be reserved for very rare disseminated cases. In GML patients, at diagnosis but even after complete remission, special attention must be paid to an increased risk of gastric adenocarcinoma, especially in the presence of associated gastric precancerous lesions (gastric atrophy and gastric intestinal metaplasia), which requires adequate endoscopic surveillance of these patients.

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