Diagnosis of leiomyosarcoma of colon

Kiran, P. Shashi; Shiny, P. M.; Dhanya, KS; Aravindan, K P

doi:10.4103/0973-1482.154017

Cited by 12 publications

(6 citation statements)

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“…Moreover, LMS is an extremely rare cancer representing 3–6% of all GI mesenchymal tumors. They arise from muscularis mucosae or propria occurring mostly in middle-aged males [3] , [5] . During the pre-KIT area, most of the GI mesenchymal malignancies were wrongfully diagnosed as leiomyoma, LMS, or leiomyoblastomas.…”

Section: Discussionmentioning

confidence: 99%

Two cases of primary leiomyosarcoma of sigmoid colon treated with laparoscopic surgery: A case report and a review of literature

Bananzadeh

Mokhtari

Sohooli

et al. 2021

International Journal of Surgery Case Reports

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Introduction and importance Leiomyosarcoma (LMS) of the colon is an extremely rare and highly invasive tumor arising from the muscularis propria of the gastrointestinal tract. After the introduction of oncogenic role of KIT by immunohistochemistry (IHC), the reported cases of gastrointestinal leiomyosarcoma were highly limited. True LMS of the colon is such a rare disorder that there isn't much description of its nature. Case presentation We reported two very rare cases of primary leiomyosarcoma of sigmoid colon, which referred to our institution with symptoms of abdominal pain, lower GI bleeding and fatigue. After the initial investigations, both patients were diagnosed with primary LMS of sigmoid colon that underwent laparoscopic tumor resection. Clinical discussion The classical colonic LMS presents with a vast majority of non-specific symptoms including mild abdominal pain, fresh/obscure rectal bleeding, and weight loss. The most common location for colonic LMS is the sigmoid colon, and ascending colon. The prognostic factors for the disease outcome have not been established properly; however, patient age, tumor size/grade, and local/distant dissemination are of great importance. Conclusion Herein, we reported two rare cases of primary leiomyosarcoma of sigmoid colon that was treated with laparoscopic surgery.

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Section: Discussionmentioning

confidence: 99%

Two cases of primary leiomyosarcoma of sigmoid colon treated with laparoscopic surgery: A case report and a review of literature

Bananzadeh

Mokhtari

Sohooli

et al. 2021

International Journal of Surgery Case Reports

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“…Moreover, LMS is an extremely rare cancer representing 3-6% of all GI mesenchymal tumors. They arise from muscularis mucosae or propria occurring mostly in middle-aged males [3,4]. In the pre-KIT area, most of the GI mesenchymal malignancies were wrongfully diagnosed as leiomyoma, LMS, or leiomyoblastomas.…”

Section: Discussionmentioning

confidence: 99%

Two cases of primary leiomyosarcoma of sigmoid colon treated with laparoscopic surgery: a case report and a review of literature

Bananzadeh

Mokhtari

Sohooli

et al. 2021

Preprint

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Background Leiomyosarcoma (LMS) of the colon is an unbelievably rare and highly invasive tumor arising from the muscularis propria of the gastrointestinal tract. After the introduction of the oncogenic role of KIT by immunohistochemistry (IHC), the reported cases of gastrointestinal leiomyosarcoma were limited. True LMS of the colon is such a rare disorder that there isn’t enough description of its nature. The classical colon LMS presents with a vast majority of non-specific symptoms including mild abdominal pain, fresh/obscure rectal bleeding, and weight loss. Case presentation: we experienced two extremely rare cases of colonic LMS. First patient was a 48-year-old man referred to our surgical outpatient clinic with mild intermittent abdominal pain and occasional rectal bleeding. After the initial investigation patient underwent colonoscopy that was suggestive of a large polypoid mass in 15 centimeters from the anal verge. Histopathology and Subsequent immunohistochemistry were in favor of LMS of sigmoid colon, and he underwent Laparoscopic anterior resection. The second patient was a 49-year-old man with 3-month history of fatigue, melena, and unintentional weight loss. Colonoscopy revealed a large circumferential mass in sigmoid colon 40 cm from the anal verge with the diagnosis of LMS. He underwent Laparoscopic left hemicolectomy. Conclusion: Herein, we reported two rare cases of primary leiomyosarcoma of sigmoid colon treated with laparoscopic surgery. The tumors were surgically removed via laparoscopic approach. Overall, colonic LMS is a highly invasive neoplasm with poor oncologic outcome.

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“…Yaren A et al [20] reported that a 66-year-old female with CLMS underwent adjuvant chemotherapy with ifosfamide plus doxorubicin after surgery, and no evidence of disease was observed during his follow-up time. Kiran P et al [23] reported that a 54-year old male with LMS of the colon received postoperative chemotherapy with ifosfamide and doxorubicin for six cycles, but then he developed a recurrence after a disease-free period of half a year. After a surgery for recurrence, he was still alive well without disease.…”

Section: Discussionmentioning

confidence: 99%

A pooled analysis of risk factors of surgically treated leiomyosarcoma of the colon in adults

Wang

Yuan³

et al. 2020

World J Surg Onc

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Background: This current systematic review aimed to evaluate the role of surgical management and risk factors by pooled cases from all identified patients with colonic leiomyosarcomas. Methods: The authors searched the Ovid MEDLINE, Embase, PubMed, and Cochrane databases using the keywords "colonic," "colon," and "leiomyosarcoma." Risk factors of colonic leiomyosarcoma in the pooled cohort were also evaluated. Results: Between 1923 and 2019, 41 cases of colonic leiomyosarcoma were identified in 22 (53.7%) males and 19 (46.3%) females, with a mean and median age of 58.7 ± 2.2 years and 56.0 years. According to univariate analysis, smaller tumor size < 8 cm was significantly associated with longer progression-free survival (HR = 6.957, 95% CI 1.405-34.442; p = 0.017), and younger age < 60 years was trending toward better overall survival (HR = 2.765, 95% CI 0.924-8.272; p = 0.069). Conclusions: Colonic leiomyosarcomas are rare neoplasms with aggressive clinical behaviors. Age < 60 years and tumor size < 8 cm were favorable factors for patients' better survival. Literature search strategyThe search protocol, including the search questions and inclusion and exclusion criteria, was developed a priority according to the Preferred Reporting Items for systematic reviews and meta-analysis (PRISMA) guidelines. We performed a systematic literature research of the Ovid Medline, Embase, Pubmed, and Cochrane Library Database from 1923 to 2019. The keywords used in the search were "colonic," "colon," and "leiomyosarcoma." We further reviewed all the references provided in the publication and incorporate

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Diagnosis of leiomyosarcoma of colon

Cited by 12 publications

References 0 publications

Two cases of primary leiomyosarcoma of sigmoid colon treated with laparoscopic surgery: A case report and a review of literature

Two cases of primary leiomyosarcoma of sigmoid colon treated with laparoscopic surgery: A case report and a review of literature

Two cases of primary leiomyosarcoma of sigmoid colon treated with laparoscopic surgery: a case report and a review of literature

A pooled analysis of risk factors of surgically treated leiomyosarcoma of the colon in adults

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