Diagnosis of Kikuchi-Fujimoto Disease: A Comparison between Open Biopsy and Minimally Invasive Ultrasound-Guided Core Biopsy

Yu, Shan–Chi; Chen, Chun‐Nan; Huang, Hsin-I; Chen, Tseng‐Cheng; Wang, Cheng-Ping; Lou, Pei‐Jen; Ko, Jenq‐Yuh; Hsiao, Tzu‐Yu; Yang, Tsung‐Lin

doi:10.1371/journal.pone.0095886

Cited by 19 publications

(14 citation statements)

References 22 publications

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“…4 Ultrasound-guided core biopsy (USCB) is a proven diagnostic tool in head and neck tumours. [5][6][7] In this study, we explored the utility of USCB to diagnose BOT malignancy.…”

mentioning

confidence: 99%

Application of ultrasound‐guided core biopsy as a novel diagnostic tool for base of tongue cancer: Our experiences with ten patients

Chen

Lin

et al. 2016

Clinical Otolaryngology

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“…4 Ultrasound-guided core biopsy (USCB) is a proven diagnostic tool in head and neck tumours. [5][6][7] In this study, we explored the utility of USCB to diagnose BOT malignancy.…”

mentioning

confidence: 99%

Application of ultrasound‐guided core biopsy as a novel diagnostic tool for base of tongue cancer: Our experiences with ten patients

Chen

Lin

et al. 2016

Clinical Otolaryngology

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“…Yu et al . reported that appropriate diagnostic material can be obtained by ultrasound-guided biopsy, which can be an optimal first-line diagnostic measure [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

A white man with Kikuchi-Fujimoto disease mimicking lymphoma, preceded by frequent episodes of tonsillitis: a case report

et al. 2017

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BackgroundKikuchi-Fujimoto disease is a very rare cause of benign lymphadenopathy affecting mainly young Asiatic females. Little is known about the causative agent of Kikuchi-Fujimoto disease; however, there are hypotheses of infectious, autoimmune, or hyperimmune background of the disease that have not yet been confirmed in the conducted studies. Frequent episodes of tonsillitis preceding the onset of Kikuchi-Fujimoto disease have not been described as yet.Case presentationA 23-year-old white man with a history of over 20 episodes of tonsillitis in the preceding 2 years was admitted to our hospital because of cervical unilateral lymphadenopathy, fever, night sweating, weight loss, and fatigue. On admission, slight tenderness of cervical lymph nodes and asymmetric palate tonsil enlargement were noted. Owing to the patient’s general symptoms and history of malignancy in his close family, a malignant disease such as lymphoma was suspected. Histopathological examination of the excised lymph node revealed areas of coagulative necrosis with abundant karyorrhectic debris, with histiocytes and lymphocytes observed at the margins of the necrotic areas. The microscopic examination led to an unexpected diagnosis of Kikuchi-Fujimoto disease. The patient was treated symptomatically. All of the patient’s symptoms, excluding tonsil enlargement, retreated within 2 months.ConclusionsIn the differential diagnosis of cervical lymphadenopathy in patients with frequent episodes of tonsillitis, Kikuchi-Fujimoto disease should be taken into account. Kikuchi-Fujimoto disease may convincingly mimic symptoms characteristic of lymphoma.

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“…In order to make a proper diagnosis the pathologically altered lymph node must be taken by surgical biopsy and histopathology must be performed [12]. It is often required to perform additional immunohistochemistry.…”

Section: Discussionmentioning

confidence: 99%

Quiz. Correct answer to the quiz. Check your diagnosis Histiocytic necrotising lymphadenitis in mediastinum mimicking thymoma or lymphoma – case presentation and literature review of Kikuchi Fujimoto disease

Błasiak

Jeleń²,

Rzechonek³

et al. 2016

pjp

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Kikuchi Fujimoto disease (KFD) as a rare self-limiting lymphadenopathy of short and benign course concerns most frequently the lymph nodes of the neck. The most common symptoms are painfulness of the diseased area, fever and night sweating. The etiology is not well understood, but in the role of pathogenesis viral, autoimmune and genetic factors are taken into account. In the presented case of 37-year-old female it was necessary to exclude diseases such as lymphoma or thymoma because of atypical mediastinal location of Kikuchi Fujimoto disease. After multidisciplinary consultation the lymph node was resected from the mediastinum with videothoracoscopic approach. The diagnosis was difficult for the pathologist because of the large percentage of necrosis of the lymph node but the image was typical for histiocytic necrotizing lymphadenitis. Two cases of patients with KFD limited to the mediastinum have been previously reported in the literature. This article presents the world's first reported case of this disease in the topographic location of the thymus. Furthermore, a review of current literature was made.

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Diagnosis of Kikuchi-Fujimoto Disease: A Comparison between Open Biopsy and Minimally Invasive Ultrasound-Guided Core Biopsy

Cited by 19 publications

References 22 publications

Application of ultrasound‐guided core biopsy as a novel diagnostic tool for base of tongue cancer: Our experiences with ten patients

Application of ultrasound‐guided core biopsy as a novel diagnostic tool for base of tongue cancer: Our experiences with ten patients

A white man with Kikuchi-Fujimoto disease mimicking lymphoma, preceded by frequent episodes of tonsillitis: a case report

Quiz. Correct answer to the quiz. Check your diagnosis Histiocytic necrotising lymphadenitis in mediastinum mimicking thymoma or lymphoma – case presentation and literature review of Kikuchi Fujimoto disease

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