Diagnosis of insulinoma in the dog: A study of 11 cases

Dunn, J. K.; Heath, M. F.; Herrtage, M. E.; Jackson, K. F.; Walker, M.

doi:10.1111/j.1748-5827.1992.tb01041.x

Cited by 21 publications

(13 citation statements)

References 5 publications

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“…Paired plasma glucose and serum insulin concentrations were measured in all dogs. In all cases, the insulin:glucose ratio was in excess of 4·2 μ/mol, suggestive of insulinoma (Kruth and others 1982, Dunn and others 1992).…”

Section: Resultsmentioning

confidence: 99%

Improved survival in a retrospective cohort of 28 dogs with insulinoma

Polton

White

Brearley

et al. 2006

J of Small Animal Practice

138

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Survival times in this study exceed those in other studies published previously. In part, this is explained by an improved remission duration following surgery compared with previous reports. More striking though is the longevity of patients following institution of medical therapy. These data give strong objective support to the role of medical therapy in the management of canine insulinoma, including following relapse after surgically induced remission.

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Section: Resultsmentioning

confidence: 99%

Improved survival in a retrospective cohort of 28 dogs with insulinoma

Polton

White

Brearley

et al. 2006

J of Small Animal Practice

138

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“…Pancreatic b cell neoplasia could not be ruled out in this case. In the second dog with hyperinsulinaemia, a 2-year-old male Boxer (insulin concentration = 1653 pmol/L; glucose concentration = 2.9 mmol/L), the insulin concentration was dramatically higher than normal physiological values, and is higher even than values commonly encountered in dogs with b-cell neoplasia (Dunn et al, 1992). This dog was also moderately hypoglycaemic, and was collapsed despite a haematocrit of 27%.…”

Section: Discussionmentioning

confidence: 99%

Plasma insulin concentrations in hypoglycaemic dogs with Babesia canis rossi infection

Rees¹,

Schoeman²

2008

Veterinary Parasitology

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Hypoglycaemia has been identified as a life-threatening metabolic complication in almost 20% of severely ill dogs suffering from babesiosis due to Babesia canis rossi infection, and has been correlated with mortality. Hyperinsulinaemia as a result of inappropriate insulin secretion may precipitate hypoglycaemia, and has been suggested as a possible cause of hypoglycaemia in human and murine malaria. This prospective, cross-sectional, observational study, including 94 dogs with naturally occurring virulent babesiosis, sought to identify the presence of inappropriate insulin secretion in hypoglycaemic canine babesiosis. Pre-treatment jugular blood samples were collected for simultaneous determination of plasma glucose and insulin concentrations. Animals were retrospectively divided into three groups: hypoglycaemic (BG < 3.3 mmol/L; n = 16), normoglycaemic (BG 3.3-5.5 mmol/L; n = 62), and hyperglycaemic (BG > 5.5 mmol/L; n = 16). The median insulin concentrations for the hypoglycaemic, normoglycaemic, and hyperglycaemic groups were 10.7 pmol/L, 10.7 pmol/L, and 21.7 pmol/L, respectively. Statistical analysis revealed no significant difference in insulin concentration between the three groups. Additionally, the median insulin concentration in the hypoglycaemic and normoglycaemic groups was below the detection limit of the assay, suggesting that insulin secretion was appropriately low (i.e. undetectable) in these cases. Only two dogs had inappropriately elevated insulin concentrations. One of these dogs was hypoglycaemic. We conclude that hyperinsulinaemia is an infrequent cause of hypoglycaemia in virulent canine babesiosis. Other causes of hypoglycaemia, such as increased glucose consumption, depletion of hepatic glycogen stores, and hepatic dysfunction with impaired gluconeogenesis, are speculated to play more important roles in the pathophysiology of hypoglycaemia in canine babesiosis.

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“…As a result, tissue utilisation of glucose continues, the hypoglycaemia worsens and ultimately clinical signs develop. The onset and severity of clinical signs is determined by the degree of hypoglycaemia and the rate at which the plasma concentration of glucose falls (Feldman and Nelson 1987). A rapid decline in the plasma glucose concentration may occur with fasting, exercise or excitement in dogs with insulinomas.…”

Section: Discussionmentioning

confidence: 99%

Insulin‐secreting tumours of the canine pancreas: Clinical and pathological features of 11 cases

Dunn

Bostock

Herrtage

et al. 1993

J of Small Animal Practice

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This paper describes the clinical and pathological features of 11 dogs with insulin‐secreting tumours of the pancreas. All the dogs showed episodic weakness or collapse. The diagnosis was made on fasting plasma glucose and serum insulin concentrations, the insulimglucose ratio, and the results of an intravenous glucose tolerance test. Ten of the dogs had exploratory laparotomy, and partial pancreatectomy was performed in nine of the cases. One case was euthanased at surgery because of widespread metastases. The tumours were graded histologically and the results compared with the time to recurrence of clinical signs and postoperative survival time. Postoperative survival time for dogs which died or were euthanased as a direct result of tumour recurrence, and time to recurrence of clinical signs were calculated from actuarial survival curves. The median time to recurrence of clinical signs after surgery was 12 months (range from four to 16 months; mean time to recurrence of clinical signs 12 months). Two cases died of unrelated disease, without recurrence of hypoglycaemic signs. The median postoperative survival time was 14 months (range 10 to 33 months; mean survival time 15 months). There is a suggestion that tumours with a high mitotic count carried a worse prognosis.

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Diagnosis of insulinoma in the dog: A study of 11 cases

Cited by 21 publications

References 5 publications

Improved survival in a retrospective cohort of 28 dogs with insulinoma

Improved survival in a retrospective cohort of 28 dogs with insulinoma

Plasma insulin concentrations in hypoglycaemic dogs with Babesia canis rossi infection

Insulin‐secreting tumours of the canine pancreas: Clinical and pathological features of 11 cases

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