Diagnosis of <i>Helicobacter pylori</i> infection

Bessède, Emilie; Arantes, Vitor; Mégraud, Françis; Coelho, Luiz Gonzaga Vaz

doi:10.1111/hel.12404

Cited by 18 publications

(17 citation statements)

References 57 publications

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“…Recently, with the technological advancement of endoscopic imaging, there has been increasing interest in the real-time identification of HP infection during the endoscopic procedure without biopsies, resulting in cost reduction and early diagnosis of infection (69) . The Japanese school divides the status of the gastric mucosa into three categories based on endoscopic findings: normal gastric mucosa without HP infection (absence of gastritis), active HP infection (active gastritis), and previous HP infection (inactive gastritis).…”

Section: Level Of Evidence: 1a Grade Of Recommendation: Amentioning

confidence: 99%

Ivth Brazilian Consensus Conference on Helicobacter Pylori Infection

Coelho

Marinho

Genta

et al. 2018

Arq. Gastroenterol.

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Significant progress has been obtained since the III Brazilian Consensus Conference on H. pylori infection held in 2012, in Bento Gonçalves, Brazil, and justify a fourth meeting to establish updated guidelines on the current management of H. pylori infection. Therefore, the Núcleo Brasileiro para Estudo do Helicobacter pylori e Microbiota (NBEHPM), association linked to Brazilian Federation of Gastroenterology (FBG) held its fourth meeting again in Bento Gonçalves, RS, Brazil, on August 25-27, 2017. Twenty-six delegates, including gastroenterologists, endoscopists, and pathologists from the five regions of Brazil as well as one international guest from the United States, participated in the meeting. The participants were invited based on their knowledge and contribution to the study of H. pylori infection. The meeting sought to review different aspects of treatment for infection; establish a correlation between infection, dyspepsia, intestinal microbiota changes, and other disorders with a special emphasis on gastric cancer; and reassess the epidemiological and diagnostic aspects of H. pylori infection. Participants were allocated into four groups as follows: 1) Epidemiology and Diagnosis, 2) Dyspepsia, intestinal microbiota and other afections, 3) Gastric Cancer, and, 4) Treatment. Before the consensus meeting, participants received a topic to be discussed and prepared a document containing a recent literature review and statements that should be discussed and eventually modified during the face-to-face meeting. All statements were evaluated in two rounds of voting. Initially, each participant discussed the document and statements with his group for possible modifications and voting. Subsequently, during a second voting in a plenary session in the presence of all participants, the statements were voted upon and eventually modified. The participants could vote using five alternatives: 1) strongly agree; 2) partially agree; 3) undecided; 4) disagree; and 5) strongly disagree. The adopted consensus index was that 80% of the participants responded that they strongly or partially agreed with each statement. The recommendations reported are intended to provide the most current and relevant evidences to management of H. pylori infection in adult population in Brazil.

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Section: Level Of Evidence: 1a Grade Of Recommendation: Amentioning

confidence: 99%

Ivth Brazilian Consensus Conference on Helicobacter Pylori Infection

Coelho

Marinho

Genta

et al. 2018

Arq. Gastroenterol.

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“…Lastly, endoscopy is an impossible procedure for subjects such as pregnant women, children, and elderly patients [ 26 , 42 ]. There are two major approaches to noninvasive tests to diagnosis the H. pylori infection: UBT and serological examinations [ 26 , 43 ]. The main superiority of these methods is their easy applications in epidemiological studies.…”

Section: Endoscopy: a Pivotal Approach In Diagnosis Of Hmentioning

confidence: 99%

“…In the case positive result, an immunologic complex with the red latex-labeled MAb 21 Ge will be produced and then it moves till it the red color line becomes visible in the test strip. Currently, there is a good agreement between published guidelines and consensuses that SAT using monoclonal antibodies is one of the best approaches in the measurement of successful eradication of the bacterium and also for primary detection of this microorganism in clinical settings [ 33 , 43 , 55 , 65 – 67 ].…”

Section: Stool Antigen Test (Sat)mentioning

confidence: 99%

Diagnosis ofHelicobacter pyloriUsing Invasive and Noninvasive Approaches

Abadi

2018

Journal of Pathogens

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Helicobacter pylori (H. pylori) as gram-negative and spiral microorganism is responsible for colonization in the gastric microniche for more than 50% of world population. Recent studies have shown a critical role of H. pylori in the development of peptic ulcers, gastric mucosa-associated lymphoid tissue (MALT) lymphoma, and gastric cancer. Over the past decade, there has been a sharp interest to use noninvasive tests in diagnosis of the H. pylori infection. During the years after discovery by Marshall and Warren, it has been frequently declared that the rapid urease test (RUT) is one of the cheapest and rapid diagnostic approaches used in detecting the infection. Although the specificity and sensitivity are durable for this test, clinical experiences had shown that the ideal results are only achieved only if we take biopsies from both corpus and antrum at the same time. Given the diagnosis of the H. pylori in clinical samples, gastroenterologists are facing a long list of various molecular and nonmolecular tests. We need more in-depth researches and investigations to correctly generalize rapid and accurate molecular tests determining both bacterial identity and antibiotic resistance profile.

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“…After 8-12 h fasting period, breath samples were collected before and 10 min after the administration of 13 C urea capsule with 200 ml water. H. pylori infection was considered to be negative if 13 CO 2 value was below a 2.5% level in the breath sample after 10 min [21,22].…”

Section: Detection Of Small Intestinal Bacterial Overgrowth (Sibo) Anmentioning

confidence: 99%

Patients with dyspepsia have impaired mucosal integrity both in the duodenum and jejunum: in vivo assessment of small bowel mucosal integrity using baseline impedance

et al. 2019

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Background Recent studies reported that impaired proximal duodenal mucosa, assessed by duodenal biopsy, could play an important role in the development of dyspeptic symptoms. The aims of this study were (a) to develop a method to measure ''in vivo'' duodenal and jejunal baseline impedance (BI) and (b) to assess small bowel mucosal integrity in patients with functional dyspepsia (FD) and healthy controls (HC). Methods We recruited 16 patients with FD and 15 HC. All subjects underwent ambulatory duodeno-jejunal manometry combined with impedance (HRM/Z), BI were determined by measuring impedance immediately after the passage of nocturnal migrating motor complex (MMC) phase IIIs. Results The number of MMC phase IIIs in FD was significantly lower than that in HC (2.6 ± 1.4 vs 4.8 ± 1.7, p \ 0.001). The BI in patients was significantly lower than that in HC in D1(164.2 ± 59.8 X in FD and 243.1 ± 40.5 X in HC, p = 0.0061), D2 (191.2 ± 34.1 and 256.5 ± 91.4 X, p = 0.01), D3 (214.0 ± 76.9 and 278.1 ± 45.3 X, p = 0.009), D4 (270.8 ± 54.2 and 351.8 ± 50.2 X, p \ 0.001), and J1 (312.2 ± 55.4 and 379.3 ± 38.3 X, p = 0.001). Conclusions This is the first study reporting the duodenal and jejunal BI in vivo. The results have shown significantly lowered BI in the proximal small intestine in patients with FD compared to HC. Furthermore it suggests that measurements of small bowel BI could be used as a biomarker for diagnosis and follow up of patients with FD.

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Diagnosis of Helicobacter pylori infection

Cited by 18 publications

References 57 publications

Ivth Brazilian Consensus Conference on Helicobacter Pylori Infection

Ivth Brazilian Consensus Conference on Helicobacter Pylori Infection

Diagnosis ofHelicobacter pyloriUsing Invasive and Noninvasive Approaches

Patients with dyspepsia have impaired mucosal integrity both in the duodenum and jejunum: in vivo assessment of small bowel mucosal integrity using baseline impedance

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