Diagnosis of Hypertension due to Renal Arterial Stenosis

Birchall, Robert; Batson, Hugh M.; Anderson, Eugene G.

doi:10.1161/01.cir.29.1.6

Cited by 21 publications

(2 citation statements)

References 10 publications

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“…These results are consistent with observations made in human unilateral renal arterial stenosis [2,13,14],…”

Section: Fractional Reabsorption O F Water Urinary Concentration Andsupporting

confidence: 93%

Separate Renal Concentrating Ability in Chronically Hypertensive Rats with Unilateral Goldblatt Clip

Kramer¹,

Ochwadt²

1974

Nephron

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The maximal concentrating ability of the clamped and the untouched kidney was studied in non-anesthetized Wistar rats which had been rendered hypertensive by the constriction of one renal artery. Both kidneys were able to elaborate a well-concentrated urine after dehydration and under the influence of exogenous vasopressin, whereby the clamped kidney was even superior in this respect to the untouched contralateral kidney. The concentration of inulin was regularly elevated in the urine from the clamped kidney. A slight depression of RPF and GFR ran parallel with a drop of blood pressure in the course of the experiment. Total sodium excretion in the Goldblatt rats was not different from that of normal rats; in hypertensive rats, however, two thirds of the total output were accomplished by the untouched kidney. The difference in concentrating ability between the two kidneys is interpreted as a consequence of different sodium reabsorption in the ascending limb of Henle’s loop.

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“…These results are consistent with observations made in human unilateral renal arterial stenosis [2,13,14],…”

Section: Fractional Reabsorption O F Water Urinary Concentration Andsupporting

confidence: 93%

Separate Renal Concentrating Ability in Chronically Hypertensive Rats with Unilateral Goldblatt Clip

Kramer¹,

Ochwadt²

1974

Nephron

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“…This thesis is supported by the occurrence of 'exaggerated natriuresis' in other forms of hypertension, viz. phaeochromocytoma, hyperaldosteronism, Cushing's syndrome, and in the contralateral kidney in renovascular hypertension (Hanenson et al, 1959;Birchall et al, 1953;Birchall, Madsen & Anderson, 1964), and after elevation of blood pressure by the infusion of metaraminol (Vaamonde et al, 1964;Eisinger, 1966). Increased blood pressure, by virtue of changes in the compliance characteristics of the systemic vascular bed, might alter the systemic haemodynamic response to volume expansion OJlrych et al, 1964).…”

Section: Discussionmentioning

confidence: 99%

Intrarenal Pressure and Exaggerated Natriuresis in Essential Hypertension

et al. 1970

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1. Intrarenal pressure, estimated by measurement of wedged renal vein pressure, was elevated in patients with essential hypertension. Despite increased afferent arteriolar resistance, glomerular pressure was elevated indicating that the higher systemic pressure in essential hypertension is transmitted beyond the arterioles and accounts for elevation of intrarenal pressure.2. During hypertonic saline loading in hypertensives, renal arteriolar resistance falls, resulting in further increase in intrarenal pressure. Increments in intrarenal pressure paralleled increases in sodium excretion in patients with essential hypertension during the exaggerated natriuresis and in normotensive subjects after the prolonged infusion of hypertonic saline.3. The marked increase in intrarenal pressure which appears to be responsible for exaggerated natriuresis in essential hypertension is attributable to an altered (exaggerated) response of the renal arterioles. The data suggest that elevated intrarenal pressure may play a role in the regulation of sodium balance in patients with essential hypertension.While many investigators have noted that patients with essential hypertension excrete more sodium than normotensive subjects in response to the infusion of hypertonic saline, the mechanism for this exaggerated natriuresis is not known (Baldwin et al.

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Test for Pathologic Secretion of Aldosterone

Birchall¹

1968

JAMA

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Diagnosis of Hypertension due to Renal Arterial Stenosis

Cited by 21 publications

References 10 publications

Separate Renal Concentrating Ability in Chronically Hypertensive Rats with Unilateral Goldblatt Clip

Separate Renal Concentrating Ability in Chronically Hypertensive Rats with Unilateral Goldblatt Clip

Intrarenal Pressure and Exaggerated Natriuresis in Essential Hypertension

Test for Pathologic Secretion of Aldosterone

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