Diagnosis of histological gastritis based on the Kyoto classification of gastritis in Japanese subjects – including evaluation of aging and sex difference of histological gastritis

Sumi, Naoki; Haruma, Ken; Kamada, Takenobu; Suehiro, Mitsuhiko; Manabe, Noriaki; Akiyoshi, Takashi; Shiotani, Akiko; Yamanaka, Yoshiaki; Fujimoto, Sohachi; Takao, Toshihiro

doi:10.1080/00365521.2021.2002927

Cited by 7 publications

(5 citation statements)

References 24 publications

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“…This study revealed that the H. pylori infection score had a high AUC of 0.92 with the most appropriate cutoff value of 1 (sensitivity: 0.92; specificity: 0.90). At a cutoff value of 1 for the EKC score, Sumi et al [10] found similar results: EKC had a sensitivity of 98.7% and a specificity of 98.4% in diagnosing active H. pylori infection. Kang et al [26] investigated the association between EKC scores and current H. pylori infection and found an AUC of 0.843.…”

Section: Discussionmentioning

confidence: 79%

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Endoscopic Kyoto and Kimura-Takemoto Classifications Are Comparable in Predicting High-Risk Gastric Precancerous Lesions

Nguyen,

Quach,

et al. 2024

Digestion

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Background/aims: Severe and extensive gastric atrophy, extensive or incomplete gastric intestinal metaplasia, and gastric dysplasia are considered high-risk gastric precancerous lesions (HGPLs). Endoscopic findings based on the endoscopic Kyoto classification (EKC) and the Kimura-Takemoto classification (KTC) have been reported to be significantly associated with HGPLs. This study aimed to compare these two classifications in predicting active Helicobacter pylori (H. pylori) infection and HGPLs. Methods: This is a cross-sectional study conducted on naïve dyspeptic patients who underwent upper gastrointestinal endoscopy at a tertiary hospital. Endoscopic findings were scored according to the EKC and KTC classifications. Mapping biopsies were taken, and H. pylori infection was determined using a locally validated rapid urease test and histology. The performance of EKC was compared with that of KTC using the area under the receiver operating characteristic curve (AUC) in predicting active H. pylori infection and HGPLs. Results: There were 292 patients with a median age of 46 and a male-to-female ratio of 1:1. The rates of active H. pylori infection and HGPLs were 61.3% and 14.0%, respectively. The EKC was better than the KTC in predicting active H. pylori infection (AUC: 0.771 vs. 0.658, respectively; p< 0.001). However, these two classifications had comparable performance in predicting HGPLs (AUC: 0.792 vs. 0.791, respectively; p = 0.956). Conclusion: Compared to EKC, KTC is inferior in predicting active H. pylori infection but has comparable performance in predicting HGPLs.

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Section: Discussionmentioning

confidence: 79%

“…Active H. pylori infection rates were shown to increase gradually with EKC scores of 0–1, 2–3, and 4 (8.6%, 61.4%, and 85.7%, respectively) [4, 8]. The EKC could predict H. pylori infection with a sensitivity of 78.3–98.7% and a specificity of 92–98.4% [9, 10].…”

Section: Introductionmentioning

confidence: 99%

Endoscopic Kyoto and Kimura-Takemoto Classifications Are Comparable in Predicting High-Risk Gastric Precancerous Lesions

Nguyen,

Quach,

et al. 2024

Digestion

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“…Patients negative for APCA and with a history of eradication were further classified into two subgroups: patients positive (≥ 10 U/mL) and negative (< 10 U/ml) for H. pylori antibody titer. The former was defined as “present H. pylori infection cases.” The latter individuals with an atrophy grade from C0 to C1, which is regarded as an atrophy score of 0 (negative) in the Kyoto classification 37 , were defined as “ H. pylori -uninfected cases.” The patient group negative for H. pylori antibody (< 10 U/mL) and endoscopic atrophy (≥ C-2) may include those who are H. pylori -infected and those with previous infection-induced atrophic gastritis 36 , 38 , 39 . Among these patients, those with at least one positive urea breath, stool antigen, or culture test were classified as “present H. pylori infection cases,” whereas previous infection-induced atrophic gastritis cases were defined when negative results were obtained in urea breath or stool antigen tests, as we reported previously 40 .…”

Section: Methodsmentioning

confidence: 99%

Relevance of pepsinogen, gastrin, and endoscopic atrophy in the diagnosis of autoimmune gastritis

Kishikawa

Nakamura

Ojiro

et al. 2022

Sci Rep

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Simple objective modalities are required for evaluating suspected autoimmune gastritis (AIG). This cross-sectional study aimed to examine whether pepsinogen, gastrin, and endoscopic findings can predict AIG. The diagnostic performance of endoscopic findings and serology in distinguishing AIG was evaluated. AIG was diagnosed in patients (N = 31) with anti-parietal cell antibody and/or intrinsic factor antibody positivity and histological findings consistent with AIG. Non-AIG patients (N = 301) were seronegative for anti-parietal cell antibodies. Receiver operating characteristic curve analysis of the entire cohort (N = 332) identified an endoscopic atrophic grade cutoff point of O3 on the Kimura–Takemoto classification (area under the curve [AUC]: 0.909), while those of pepsinogen-I, I/II ratio, and gastrin were 20.1 ng/mL (AUC: 0.932), 1.8 (AUC: 0.913), and 355 pg/mL (AUC: 0.912), respectively. In severe atrophy cases (≥ O3, N = 58, AIG/control; 27/31), the cutoff values of pepsinogen-I, I/II ratio, and gastrin were 9.8 ng/mL (AUC: 0.895), 1.8 (AUC: 0.86), and 355 pg/mL (AUC: 0.897), respectively. In conclusion, endoscopic atrophy is a predictor of AIG. High serum gastrin and low pepsinogen-I and I/II ratio are predictors even in the case of severe atrophy, suggesting their usefulness when the diagnosis of AIG is difficult or as serological screening tests.

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“…Gambaran inflamasi yang signifikan ditemukan pada perempuan dengan kelompok usia muda. Sementara itu gambaran inflamasi pada mukosa bagian pylorus secara signifikan lebih tinggi pada kelompok usia yang lebih muda dan H. Pylori positif dibandingkan dengan kelompok lanjut usia (60-79 tahun) (Sumi et al, 2022). Studi oleh Sjomina dkk., menunjukkan bahwa infeksi H. pylori tidak merata di berbagai daerah, hal ini diasosiasikan dengan kondisi sosiodemografik, sumber air minum, dan faktor makanan (Sjomina et al, 2018).…”

Section: Kajian Pustakaunclassified

Karakteristik Demografi, Letak Kelainan Anatomi, serta Gambaran Histopatologi Responden dengan Diagnosis Klinis Gastritis

Shalmont,

Wijaya,

Kurniawan

et al. 2023

Mal Health Stu J.

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Gastritis is often used to describe clinical symptoms related to upper abdominal complaints in patients. The diagnosis of gastritis is established by combining information resulting from endoscopy examination and histological findings. This cross-sectional study aims to examine the demographic and pathological profile of gastritis patients in one of the hospitals in Jakarta, selected based on total sampling criteria using medical record data from January 2020 to December 2022. The data is presented in descriptive form. Out of 43 respondents, the mean age is 47 years and the majority are male. The most common location of pathology is in the antral part of the stomach in 29 (67.4%) respondents, with the inflammation generally being mild in 30 (69.8%) respondents. No PMN cells, atrophy, or Helicobacter pylori bacterial infection were found in 42 (97.7%) respondents, and there was no evidence of intestinal metaplasia or dysplasia in any of the respondents. The conclusion of this study is that the most common location of pathology is in the antral section with generally mild infection with a predominance of Helicobacter pylori infection. Keywords: Endoscopy, Gastritis, Histopathology ABSTRAK Gastritis sering digunakan untuk menggambarkan gejala klinis yang berkaitan dengan keluhan pasien di perut bagian atas. Diagnosis gastritis ditegakkan setelah menggabungkan informasi yang dihasilkan dari pemeriksaan endoskopi dan temuan histologis. Penelitian potong lintang ini bertujuan melihat gambaran demografi dan patologi pasien gastritis di salah satu Rumah Sakit di Jakarta yang dipilih sesuai kriteria secara total sampling menggunakan data rekam medis periode Januari 2020 hingga Desember 2022. Data disajikan dalam bentuk deskriptif. Dari 43 responden, rerata usia adalah 47 tahun dan didominasi oleh laki-laki. Letak patologi paling sering terjadi pada bagian antral gaster pada 29 (67,4%) responden, dengan sebukan sel radang kronik umumnya sedang pada 30 (69,8%) responden, tidak ada sebukan sel PMN, atrofi kelenjar dan infeksi bakteri Helicobacter pylori pada 42 (97,7%) responden, serta tidak ditemukannya metaplasia intestinal dan displasia pada seluruh responden. Kesimpulan penelitian ini berupa lokasi patologi paling umum adalah pada bagian antral dengan infeksi umumnya ringan dengan dominasi infeksi Helicobacter pylori. Kata kunci: Endoskopi, Gastritis, Histopatologi

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Diagnosis of histological gastritis based on the Kyoto classification of gastritis in Japanese subjects – including evaluation of aging and sex difference of histological gastritis

Cited by 7 publications

References 24 publications

Endoscopic Kyoto and Kimura-Takemoto Classifications Are Comparable in Predicting High-Risk Gastric Precancerous Lesions

Endoscopic Kyoto and Kimura-Takemoto Classifications Are Comparable in Predicting High-Risk Gastric Precancerous Lesions

Relevance of pepsinogen, gastrin, and endoscopic atrophy in the diagnosis of autoimmune gastritis

Karakteristik Demografi, Letak Kelainan Anatomi, serta Gambaran Histopatologi Responden dengan Diagnosis Klinis Gastritis

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