Diagnosis of Hirschsprung disease by analyzing acetylcholinesterase staining using artificial intelligence
Yannick Braun,
Florian Friedmacher,
Till‐Martin Theilen
et al.
Abstract:ObjectivesClassical Hirschsprung disease (HD) is defined by the absence of ganglion cells in the rectosigmoid colon. The diagnosis is made from rectal biopsy, which reveals the aganglionosis and the presence of cholinergic hyperinnervation. However, depending on the method of rectal biopsy, the quality of the specimens and the related diagnostic accuracy varies substantially. To facilitate and objectify the diagnosis of HD, we investigated whether software‐based identification of cholinergic hyperinnervation i… Show more
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