Diagnosis of heterotopic bone marrow in the mediastinum using52Fe and positron emission tomography

Borgies, P.; Ferrant, Augustin; Leners, N.; Michaux, Jean‐Louis; Bol, Anne; Michel, Christian; Cogneau, M.; Sokal, G.

doi:10.1007/bf00631772

Cited by 13 publications

(2 citation statements)

References 6 publications

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“…A negative pressure at this site facilitates this phenomenon, Furthermore, physiological extramedullary haematopoiesis has been described at paravertebral sites in the pig (13), possibly as a result of reactivation of quiescent rests of embryonic haematopoiesis. Finally, there is no relationship between the degree of anaemia and the quantity of erythropoiesis in expansion areas (10).…”

Section: Patientmentioning

confidence: 97%

“…Indeed, extramedullary haematopoiesis could be prevented by early diagnosis and splenectomy: it has never been described following splenectomy in a case of hereditary spherocytosis. Splenectomy was carried out in 13 patients after the onset of extramedullary haematopoiesis (2,(6)(7)(8)(9)(10)(11). A fatty transformation of the masses has been observed subsequently on follow-Hereditary spherocytosis may present only a limited number of phenotypes by SDS-PAGE.…”

Section: Patientmentioning

confidence: 99%

See 1 more Smart Citation

Extramedullary haematopoiesis in hereditary spherocytosis simulating mediastinal tumour

Reman¹,

Carré²,

Belloy³

et al. 1997

European J of Haematology

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Section: Patientmentioning

confidence: 97%

Section: Patientmentioning

confidence: 99%

Extramedullary haematopoiesis in hereditary spherocytosis simulating mediastinal tumour

Reman¹,

Carré²,

Belloy³

et al. 1997

European J of Haematology

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Mediastinal extramedullary hematopoiesis as first manifestation of hereditary spherocytosis

et al. 1992

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Tc-99m nanocolloid scintigraphic imaging of intracranial meningeal extramedullary hematopoiesis in a patient with idiopathic myelofibrosis

Kaya

Çerçi

2006

Ann Nucl Med

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Meningeal extramedullary hematopoiesis (EMH) is a rare finding in idiopathic myelofibrosis. Intracranial EMH is typically asymptomatic and sites are usually found by chance. Diagnosis of EMH is difficult, based on clinical circumstances and the use of different diagnostic imaging modalities, such as CT, MRI or radionuclide imaging. We present a case with intracranial medullary hematopoiesis due to idiopathic myelofibrosis diagnosed with Tc-99m nanocolloid scintigraphy. Cranium SPECT images that were performed with Tc-99m nanocolloid showed increased radiotracer uptake in the bilateral parietal, bilateral frontal and left occipital bones and especially in falx cerebri of sinus sagittalis superior. In Tc-99m MDP bone scintigraphy, increased osteoblastic activity in the left frontal and parietal bones, in shoulders, knee and ankle joints, and in both metatarsal bones were seen. After gadodiamid injection, Tl weighted MRI showed diffuse contrast increased in the meningeal areas surrounding the brain. A biopsy of the mass revealed extramedullary hematopoiesis composed of erythroblasts, mature and immature myeloid cells, and megakaryocytes. It was deduced that these described foci of EMH.

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Diagnosis of heterotopic bone marrow in the mediastinum using52Fe and positron emission tomography

Abstract: A patient with hereditary spherocytosis was admitted with mediastinal masses on the chest X-ray. 52Fe and positron emission tomography (PET) showed uptake of 52Fe in the masses and established the diagnosis of thoracic extramedullary hematopoiesis.

Cited by 13 publications

References 6 publications

Extramedullary haematopoiesis in hereditary spherocytosis simulating mediastinal tumour

Extramedullary haematopoiesis in hereditary spherocytosis simulating mediastinal tumour

Mediastinal extramedullary hematopoiesis as first manifestation of hereditary spherocytosis

Tc-99m nanocolloid scintigraphic imaging of intracranial meningeal extramedullary hematopoiesis in a patient with idiopathic myelofibrosis

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