Diagnosis of hepatic inflammatory pseudotumor by fine-needle biopsy

Lin, Min; Cao, Liang; Wang, Jianwei; Zhou, Jianhua

doi:10.1016/j.jimed.2022.04.002

Cited by 2 publications

(1 citation statement)

References 14 publications

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“…Moreover, since neither imaging modalities nor biochemical tests provide conclusive evidence of IPT [15], it is not easy to distinguish IPT from malignant liver tumors including hepatocellular carcinoma, Diagnostics 2023, 13, 2857 2 of 13 cholangiocellular carcinoma, cholangiolocellular carcinoma and metastatic liver cancer. Indeed, liver tumor markers such as AFP, PIVKA II, and CEA were almost within normal limits in the reported references [16,17]; however, liver function tests such as ALT and AST showed multifield increases due to inflammation in the reported references [17].…”

Section: Introductionmentioning

confidence: 85%

Hepatic Inflammatory Pseudotumor—Focusing on Its Heterogeneity

Kim,

Koma

et al. 2023

Diagnostics

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Hepatic inflammatory pseudotumors (IPTs) are defined as benign, non-malignant, non-metastasizing tumors characterized by the presence of myofibroblastic spindle cells, hetorogenous populations of inflammatory cells, particularly plasma cells, lymphocytes and macrophages, as well as locations of fibrosis and necrosis without cellular anaplasia or atypical mitoses. Despite subsequent reports in the references, hepatic IPT remains difficult to diagnose; while posing major issues specifically for its differential diagnosis compared with that of other various benign diseases and malignant hepatic tumors. Histopathological findings are always a requisite for confirming the diagnosis, particularly given that the pathogenesis of IPT remains ambiguous to date. Hepatic IPT is a heterogeneous entity in terms of its clinical features, pathological findings, and pathogenesis. Once the diagnosis is confirmed, however, needless surgery such as wedge resection and lobectomy should be avoided. Here, we discuss the heterogeneity of hepatic IPT, its clinical features, pathological findings, and pathogenesis, and describe its differential diagnosis.

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