Diagnosis of gastrointestinal graft-versus-host disease

Iqbal, Nuzhat; Salzman, Donna; Lazenby, Audrey J.; Wilcox, C. Mel

doi:10.1016/s0002-9270(00)02043-8

Cited by 30 publications

(48 citation statements)

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“…Therefore, the segment of the gastrointestinal tract that should be biopsied for diagnosis of acute GI-GVHD remains subject to controversy. 25,26 Finally in our study, we did not expect a correlation between pathology scores and 18 F-FDG PET/CT, as 18 F-FDG PET/CT detects inflammation earlier before the onset of histological lesions, while the pathology score of GI-GVHD is based only on apoptosis and crypt loss 9 and does not take into account endothelial inflammation involved in GI-GVHD but detected by 18 F-FDG PET/CT, for example.…”

Section: Discussionmentioning

confidence: 59%

18F-FDG PET/CT for the assessment of gastrointestinal GVHD: results of a pilot study

Bodet-Milin

Malard

et al. 2013

Bone Marrow Transplant

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Section: Discussionmentioning

confidence: 59%

18F-FDG PET/CT for the assessment of gastrointestinal GVHD: results of a pilot study

Bodet-Milin

Malard

et al. 2013

Bone Marrow Transplant

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“…It is generally accepted that, while acute GVHD can involve the whole GI tract, chronic GI GVHD mostly affects the oesophagus, sparing the lower GI tract (McDonald et al, 1986) leading to desquamation of the oesophageal mucosa with submucosal fibrosis (Iqbal et al, 2000). Damage to the oesophageal mucosa eventually leads to symptoms such as dysphagia and odynophagia.…”

Section: Gastrointestinal Tractmentioning

confidence: 99%

Optimal management of chronic graft‐versus‐host disease in children

Jacobsohn

2010

Br J Haematol

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SummaryChronic graft-versus-host disease (GVHD) is a major complication after allogeneic haematopoietic stem cell transplantation (HSCT). Not only is it the major cause of late mortality in HSCT patients, but it also accounts for significant morbidity. Much of the literature on chronic GVHD has focused on adults. Chronic GVHD is of major importance in children, especially since they have years to live following the complications of chronic GVHD and its therapy. The goal is to review incidence, manifestations, and therapies, especially when applicable to the paediatric population.

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“…CMV colitis, which was proven by biopsy, was a factor in diagnosing small intestinal CMV disease; however, CMV enteritis involving only the small intestine without colon involvement may not be rare after Allo-HSCT because the small intestine is a frequent and severe site for gastrointestinal complications following Allo-HSCT. 7 In such a situation, our picture ( Figure 1a) showing ulceration detected by capsule endoscopy may be useful in diagnosing small intestinal CMV disease after Allo-HSCT. Clinical Laboratory Division, National Cancer Center Hospital, Tokyo, Japan E-mail: yakakuga@ncc.go.jp …”

mentioning

confidence: 88%

“…9 The differential diagnosis of intestinal disorders following Allo-HSCT includes intestinal GVHD, thrombotic microangiopathy, treatment-related toxicities and clostridium difficile enterocolitis as well as CMV enterocolitis. 7 Actual diagnosis is usually based on pathological examinations of endoscopically obtained mucosal biopsy specimens, but this is not possible with capsule endoscopy due to its lack of biopsy capability.…”

mentioning

confidence: 99%