“…Of the available tests, the earliest was the Cand-Tec LA assay (Ramco Laboratories, Stafford, TX), which was designed to detect circulating Candida antigen in patients with serious, disseminated infection. Unfortunately, there are conflicting reports on its overall sensitivity and specificity, especially in patients with renal failure or rheumatoid factor positivity, making it difficult to confirm the diagnosis of candidiasis by the Cand-Tec assay alone [20,21]. The mannan component of the Candida cell wall is a major antigen and the target of many serum detection assays.…”