Diagnosis of depression among adolescents – a clinical validation study of key questions and questionnaire

Haavet, Ole Rikard; Christensen, Kaj Sparle; Sirpal, Manjit Kaur; Haugen, Wenche

doi:10.1186/1471-2296-8-41

Cited by 7 publications

(4 citation statements)

References 18 publications

(16 reference statements)

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“…HSCL-25 is a well-known and widely used screening instrument [ 22 ]. We used the short version HSCL-10 [ 23 ], which is considered a good screening instrument in primary health care settings, and research [ 24 , 25 ]. GDAS is an easy to administer scale [ 26 ] that has been validated in the DRC [ 27 ].…”

Section: Methodsmentioning

confidence: 99%

Dietary cyanogen exposure and early child neurodevelopment: An observational study from the Democratic Republic of Congo

et al. 2018

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BackgroundDietary cyanogen exposure from ingesting bitter (toxic) cassava as a main source of food in sub-Saharan Africa is related to neurological impairments in sub-Saharan Africa. We explored possible association with early child neurodevelopmental outcomes.MethodsWe undertook a cross-sectional neurodevelopmental assessment of 12–48 month-old children using the Mullen Scale of Early Learning (MSEL) and the Gensini Gavito Scale (GGS). We used the Hopkins Symptoms Checklist-10 (HSCL-10) and Goldberg Depression Anxiety Scale (GDAS) to screen for symptoms of maternal depression-anxiety. We used the cyanogen content in household cassava flour and urinary thiocyanate (SCN) as biomarkers of dietary cyanogen exposure. We employed multivariable generalized linear models (GLM) with Gamma link function to determine predictors of early child neurodevelopmental outcomes.ResultsThe mean (SD) and median (IQR) of cyanogen content of cassava household flour were above the WHO cut-off points of 10 ppm (52.18 [32·79]) and 50 (30–50) ppm, respectively. Mean (SD) urinary levels of thiocyanate and median (IQR) were respectively 817·81 (474·59) and 688 (344–1032) μmole/l in mothers, and 617·49 (449·48) and 688 (344–688) μmole/l in children reflecting individual high levels as well as a community-wide cyanogenic exposure. The concentration of cyanide in cassava flour was significantly associated with early child neurodevelopment, motor development and cognitive ability as indicated by univariable linear regression (p < 0.05). After adjusting for biological and socioeconomic predictors at multivariable analyses, fine motor proficiency and child neurodevelopment remained the main predictors associated with the concentration of cyanide in cassava flour: coefficients of -0·08 to -.15 (p < 0·01). We also found a significant association between child linear growth, early child neurodevelopment, cognitive ability and motor development at both univariable and multivariable linear regression analyses coefficients of 1.44 to 7.31 (p < 0·01).ConclusionDietary cyanogen exposure is associated with early child neurodevelopment, cognitive abilities and motor development, even in the absence of clinically evident paralysis. There is a need for community-wide interventions for better cassava processing practices for detoxification, improved nutrition, and neuro-rehabilitation, all of which are essential for optimal development in exposed children.

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Section: Methodsmentioning

confidence: 99%

Dietary cyanogen exposure and early child neurodevelopment: An observational study from the Democratic Republic of Congo

et al. 2018

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“…To measure depressive symptoms, we used the 10-item Hopkins Symptom Checklist for depression (HSCL-10) [24]. HSCL is a prime candidate as a valid clinical instrument for identifying depression in the primary health care [25], and in research [26,27]. It has been used in the similar context in Uganda [28].…”

Section: Primary Independent Variables: Depressive Symptoms and Loss mentioning

confidence: 99%

Depressive Symptoms, Loss of Appetite and Under Nutrition among Treated HIV Patients: A Cross Sectional Study in Goma, the Democratic Republic of Congo

Akilimali¹

2016

JNHFS

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Background: The study explored the association between the depressive symptoms, loss of appetite and under nutrition among treated HIV patients in Goma, a post conflict setting. Methodology: This was a cross-sectional survey carried out from February 1 st to March 3 rd , 2016. The prevalence of depressive symptoms and loss of appetite were estimated. A logistic regression model was used to identify the associations between under nutrition, loss of appetite and depressive symptoms, adjusted for other covariates.

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“…The protocol was published in 2007. 28 A total of 43 GPs in Aarhus (n = 18) and Oslo (n = 25) were invited to participate in a cross-sectional validation study of adolescents. Included in the study were all patients aged 14-16 years listed with the GPs.…”

Section: Methodsmentioning

confidence: 99%

“…28 During the study, however, the sensitivity of the instruments proved to be higher than first approximated, and the recruitment of participants was therefore stopped early. One final possible objection is that the gold standard instrument used, CIDI, is conducted as a telephone interview.…”

Section: Comparison With Existing Literaturementioning

confidence: 99%

Identifying depression among adolescents using three key questions: a validation study in primary care

et al. 2016

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Diagnosis of depression among adolescents – a clinical validation study of key questions and questionnaire

Abstract: Background: The objective of the study is to improve general practitioners' diagnoses of adolescent depression. Major depression is ranked fourth in the worldwide disability impact.

Cited by 7 publications

References 18 publications

Dietary cyanogen exposure and early child neurodevelopment: An observational study from the Democratic Republic of Congo

Dietary cyanogen exposure and early child neurodevelopment: An observational study from the Democratic Republic of Congo

Depressive Symptoms, Loss of Appetite and Under Nutrition among Treated HIV Patients: A Cross Sectional Study in Goma, the Democratic Republic of Congo

Identifying depression among adolescents using three key questions: a validation study in primary care

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