Diagnosis of Coeliac Disease at Open-Access Endoscopy

Dickey, William

doi:10.1080/00365529850171882

Cited by 39 publications

(12 citation statements)

References 14 publications

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“…During routine upper GI tract endoscopy, Dickey obtained samples from the second part of the duodenum in patients suspected of having celiac disease-related findings and identified celiac disease in 8 (1.6%) of their 500-patient series [19]. In another study conducted on 129 celiac disease patients, Dickey and Hughes found that 77% had at least one Fig.…”

Section: Discussionmentioning

confidence: 97%

Correlation of Clinical and Histopathological with Endoscopic Findings of Celiac Disease in the Turkish Population

et al. 2007

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Endoscopic findings have been described for the diagnosis of celiac disease but the relationship among the clinical presentation, endoscopic markers, and the degree of histopathological findings is not clear. Thirty patients who were thought to have celiac disease were included in this study. Biopsies taken from the duodenum were examined histopathologically. The relationship among the endoscopic, clinical, and histopathological findings were investigated. Partial villous atrophy was seen in 14 patients (46.6%), and subtotal and total villous atrophy were seen in 6 (20%) patients each. Eighty six percent of patients with a mosaic appearance, 76% of patients with the finding of loss of folds, and 90% of patients with scalloping on endoscopy had either partial villous atrophy, subtotal villous atrophy, or total villous atrophy on biopsy. We conclude that endoscopic findings in celiac disease can reveal valuable information both for diagnosis and for demonstration of the severity of the disease state.

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Section: Discussionmentioning

confidence: 97%

Correlation of Clinical and Histopathological with Endoscopic Findings of Celiac Disease in the Turkish Population

et al. 2007

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“…Although their sensitivity has been demonstrated to vary in different studies (ranging from 6 to 98.7%), these markers are commonly searched to facilitate diagnosis of CD (6,(11)(12)(13)(14)(15).…”

Section: Discussionmentioning

confidence: 99%

High-Resolution Magnifying Upper Endoscopy in a Patient with Patchy Celiac Disease

Cammarota

Martino

et al. 2005

Dig Dis Sci

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“…Endoscopic markers of duodenal villous atrophy, with mosaic pattern and scalloping of folds, have been suggested as characteristic features of CD (12) (Figure 1). Applying this method DICKEY (11) observed a 1.6% prevalence of CD among individuals submitted to endoscopies due to digestive complaints. In fact, evaluation of endoscopic results in a large number of patients during standard examinations demonstrated these indicators as being disappointingly insensitive, with markers present in only 58% of those with partial mucosa atrophy (13) .…”

Section: Discussionmentioning

confidence: 99%

Prevalence of celiac disease in dyspeptic patients

Lima

Gandolfi

Pires

et al. 2005

Arq. Gastroenterol.

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BACKGROUND: Celiac disease is one of the most common dietary-mediated inflammatory enteropathies that occur in genetically predisposed individuals in response to gluten intolerance. This disorder has become more common than in the past, even if it frequently remains undetected for long periods of time. The screening of patients with dyspepsia, a symptom that can be a manifestation of celiac disease, may allow an early identification of affected individuals. Endoscopy and serological tests may have an important role in the management of these patients. AIMS: Determining the prevalence of celiac disease in dyspeptic patients submitted to routine diagnostic upper gastrointestinal endoscopy. PATIENTS/METHODS: Endoscopic findings, duodenal biopsy histological specimens and serological test results were assessed and compared in 142 patients consecutively admitted with dyspeptic symptoms between October 2001 and October 2003. RESULTS: An endoscopic pattern suggestive of celiac disease was observed in four patients. The IgG-AGA assay was positive in 24 patients. Two of the IgG-AGA positive patients also yielded positive results on the IgA-EMA test and concomitantly disclosed endoscopic pattern and histological features in duodenal biopsy compatible with celiac disease. Abnormal endoscopic findings were notably marked in biopsy proven celiac patients. Therefore, a 1.4% prevalence of celiac disease was observed in this study group. CONCLUSIONS: The high prevalence of celiac among dyspeptic symptomatic individuals indicates that they are a higher risk group for developing celiac disease. Undiagnosed celiac disease may be inferred by endoscopic markers of duodenal villous atrophy. Endoscopic findings, however, may be inadequate to suitably diagnose this disease and consequently the incorporation of diagnostic serologic assays of celiac disease in routine testing for dyspepsia is strongly recommended.

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Diagnosis of Coeliac Disease at Open-Access Endoscopy

Abstract: There is a high prevalence of coeliac disease among patients undergoing OAE, which is relevant to their clinical symptoms and which can be identified by careful endoscopic inspection of the duodenum.

Cited by 39 publications

References 14 publications

Correlation of Clinical and Histopathological with Endoscopic Findings of Celiac Disease in the Turkish Population

Correlation of Clinical and Histopathological with Endoscopic Findings of Celiac Disease in the Turkish Population

High-Resolution Magnifying Upper Endoscopy in a Patient with Patchy Celiac Disease

Prevalence of celiac disease in dyspeptic patients

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