Diagnosis of cirrhosis in patients with chronic hepatitis C genotype 4: Role of ABCB11 genotype polymorphism and plasma bile acid levels

Besheer, Tarek; Arafa, Mostafa A.; El-Maksoud, M. Abd; Elalfy, Hatem; Amany, Hasson; Zalata, Khaled; Elkashef, Wagdi; Elshahawy, Heba; Raafat, Doaa; Elemshaty, Wafaa; Elsayed, Eman; Zaghloul, Hosam; Razek, Ahmed Abdel Khalek Abdel; El-Bendary, Mahmoud

doi:10.5152/tjg.2018.17570

Cited by 21 publications

(10 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Stage 3 analysis included replicating SNPs as well as SNPs that have been previously reported to associate with cirrhosis in subpopulations, as described in the introduction (Table ) . As above, we included only SNPs with minor allele count >6 in the European populations of UKBB and MGI, which corresponded to minor allele frequency >0.006.…”

Section: Methodsmentioning

confidence: 99%

“…have been previously reported to associate with cirrhosis in subpopulations, as described in the introduction (Table S1). 5,8,9,[12][13][14][15][16][22][23][24][25][26][27][28][29][30][31][32] As above, we included only SNPs with minor allele count >6 in the European populations of UKBB and MGI, which corresponded to minor allele frequency >0.006. For stage 3 SNPs, a cut-off of P < .05 in either UKBB or MGI was used because there was prior knowledge of their role in liver disease and fibrosis.…”

Section: Stage 3 Analysis Included Replicating Snps As Well As Snps Thatmentioning

confidence: 99%

See 1 more Smart Citation

Genetic variants that associate with cirrhosis have pleiotropic effects on human traits

Chen

et al. 2020

Liver International

View full text Add to dashboard Cite

Background and Aims Cirrhosis is characterized by extensive fibrosis of the liver and is a major cause of liver‐related mortality. Cirrhosis is partially heritable but genetic contributions to cirrhosis have not been systemically explored. Here, we carry out association analyses with cirrhosis in two large biobanks and determine the effects of cirrhosis associated variants on multiple human disease/traits. Methods We carried out a genome‐wide association analysis of cirrhosis as a diagnosis in UK BioBank (UKBB; 1088 cases vs. 407 873 controls) and then tested top‐associating loci for replication with cirrhosis in a hospital‐based cohort from the Michigan Genomics Initiative (MGI; 875 cases of cirrhosis vs. 30 346 controls). For replicating variants or variants previously associated with cirrhosis that also affected cirrhosis in UKBB or MGI, we determined single nucleotide polymorphism effects on all other diagnoses in UKBB (PheWAS), common metabolic traits/diseases and serum/plasma metabolites. Results Unbiased genome‐wide association study identified variants in/near PNPLA3 and HFE, and candidate variant analysis identified variants in/near TM6SF2, MBOAT7, SERPINA1, HSD17B13, STAT4 and IFNL4 that reproducibly affected cirrhosis. Most affected liver enzyme concentrations and/or aspartate transaminase‐to‐platelet ratio index. PheWAS, metabolic trait and serum/plasma metabolite association analyses revealed effects of these variants on lipid, inflammatory and other processes including new effects on many human diseases and traits. Conclusions We identified eight loci that reproducibly associate with population‐based cirrhosis and define their diverse effects on human diseases and traits.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Stage 3 Analysis Included Replicating Snps As Well As Snps Thatmentioning

confidence: 99%

Genetic variants that associate with cirrhosis have pleiotropic effects on human traits

Chen

et al. 2020

Liver International

View full text Add to dashboard Cite

show abstract

“…In Egypt, HCC is considered a significant public health problem, where it is responsible for 33.63% and 13.54% of all cancers in males and females corres- The major risk factors for liver cancer in clinical practice are related to hepatitis C viral infection, hepatitis B viral infection, alcoholic and nonalcoholic fatty liver disease [6] [7] [8] [9]. The sequences of chronic HCV infection [10] [11] include the development of liver cirrhosis [12] [13], end stage liver diseases [14] and the progression of HCC depending on different immunological factors and genetic susceptibility [15] Alternative to surgical resection of HCC, Percutaneous thermal ablation is broadly performed as a non-invasive curative treatment for HCC [19].…”

Section: Introductionmentioning

confidence: 99%

Fusion Navigation Technique for Management of Difficult to Access Hepatocellular Carcinoma: A Single Center Experience

Nakib¹,

Zakria²,

Hassany³

et al. 2020

OJGas

Self Cite

View full text Add to dashboard Cite

“…[1,2] It is the third leading causes of cancer-related death in the world. Chronic infection with hepatitis B virus (HBV) or hepatitis C virus (HCV) has a major role in the development of the disease, therefore, the diagnosis of hepatic fibrosis and inflammation in patients with chronic hepatitis is essential for therapeutic and prognostic implications [3–6,7] Recently, new markers, including specific gene signatures, have been explored to stratify the risk of recurrence and to improve management of HCC, however, predictive biomarkers are still urgently needed.…”

Section: Introductionmentioning

confidence: 99%

Investigation of the clinical significance and prognostic value of microRNA-145 in human hepatocellular carcinoma

Fan²,

He³

2018

Medicine

View full text Add to dashboard Cite

We aimed to investigate the clinical significance and prognostic value of miR-145 in hepatocellular carcinoma (HCC).HCC tissue samples and adjacent normal liver tissues were obtained from 139 patients diagnosed with HCC. The relationships between the expression level of miR-145 and clinicopathologic factors were evaluated by Chi square test. Kaplan–Meier survival analysis with the log-rank test was used to evaluate the association between miR-145 expression and HCC prognosis.miR-145 was significantly down-regulated in HCC tissues compared with the adjacent noncancerous tissues (P < .001). Its expression level was significantly correlated with tumor size (P = .010), tumor number (P = .033), lymph node metastasis (P < .000), TNM stage (P < .001) and tumor differentiation (P < .001). Kaplan–Meier curves with log rank test showed that the overall survival of the patients with low miR-145 expression was significantly shorter in comparison with the high miR-145 expression patients (P = .043). Furthermore, multivariate analysis using the Cox proportional hazards model for all variables showed that miR-145 expression was an independent prognostic factor for overall survival (P = .033).Our results indicate that low expression of miR-145 is an independent poor prognostic factor for patients with HCC. Further investigations are needed to confirm our findings.

show abstract

Diagnosis of cirrhosis in patients with chronic hepatitis C genotype 4: Role of ABCB11 genotype polymorphism and plasma bile acid levels

Cited by 21 publications

References 19 publications

Genetic variants that associate with cirrhosis have pleiotropic effects on human traits

Genetic variants that associate with cirrhosis have pleiotropic effects on human traits

Fusion Navigation Technique for Management of Difficult to Access Hepatocellular Carcinoma: A Single Center Experience

Investigation of the clinical significance and prognostic value of microRNA-145 in human hepatocellular carcinoma

Contact Info

Product

Resources

About