2019
DOI: 10.1016/j.pdpdt.2019.05.029
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Diagnosis of cervical squamous cell carcinoma and cervical adenocarcinoma based on Raman spectroscopy and support vector machine

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Cited by 37 publications
(28 citation statements)
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“…The Raman spectra acquired with 633 and 785 nm laser lines shown strong background fluorescence, inhibiting the analysis of the acquired data. The Raman spectra acquired with the 532 nm laser presented much lower fluorescence, and thus, it was chosen for the excitation of all samples for further analysis, an approach applied by other authors [16,21,22,[26][27][28]. Even so, it was impossible to obtain clear Raman signals in three out of the seven biopsy sections, due to laser-induced fluorescence.…”
Section: Resultsmentioning
confidence: 99%
“…The Raman spectra acquired with 633 and 785 nm laser lines shown strong background fluorescence, inhibiting the analysis of the acquired data. The Raman spectra acquired with the 532 nm laser presented much lower fluorescence, and thus, it was chosen for the excitation of all samples for further analysis, an approach applied by other authors [16,21,22,[26][27][28]. Even so, it was impossible to obtain clear Raman signals in three out of the seven biopsy sections, due to laser-induced fluorescence.…”
Section: Resultsmentioning
confidence: 99%
“…The peak assignments are listed in Table 3 according to the reported literature. [11,14,[21][22][23][24][25][26][27][28] The HGG and LGG group peak intensity changes compared with the normal group are shown in Table 2. The HGG group had lower intensities than the LGG group at all specific peaks except 749 cm −1 .…”
Section: Spectral Analysismentioning
confidence: 99%
“…T A B L E 3 Raman peak attribution in normal and glioma serum [11,14,[21][22][23][24][25][26][27][28] Raman shift (cm − PCA-LDA for glioma diagnosis, an ROC curve was produced, as shown in Figure 3b, and the accuracy of the discriminant analysis results was evaluated by the area under the ROC curve. Therefore, we performed a pairwise comparison of the PCA-LDA diagnostic algorithm results.…”
Section: Principal Component Analysis (Pca) and Linear Discriminantmentioning
confidence: 99%
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“…Cervical cancer typically develops from precancerous changes over 10 to 20 years [3]. Around 90% of cervical cancer cases are squamous cell carcinomas, and 10% of cases are adenocarcinomas with a small number of cases involving other types of carcinomas [4]. Although standard treatments such as surgery and combination of chemotherapy and radiotherapy have significantly improved the clinical outcomes of cervical cancer patients in early stages, the clinical management of cervical cancer in advanced stages remains a challenge.…”
Section: Introductionmentioning
confidence: 99%