Diagnosis of Cervical Cancer With Parametrial Invasion on Whole-Tumor Dynamic Contrast-Enhanced Magnetic Resonance Imaging Combined With Whole-Lesion Texture Analysis Based on T2- Weighted Images

Abstract

Purpose: To evaluate the diagnostic value of the combination of whole-tumor dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and whole-lesion texture features based on T2-weighted images for cervical cancer with parametrial invasion. Materials and Methods: Sixty-two patients with cervical cancer (27 with parametrial invasion and 35 without invasion) preoperatively underwent routine MRI and DCE-MRI examinations. DCE-MRI parameters (K trans , K ep , and V e) and texture features (mean, skewness, kurtosis, uniformity, energy, and entropy) based on T2-weighted images were acquired by two observers. All parameters of parametrial invasion and non-invasion were analyzed by one-way analysis of variance. The diagnostic efficiency of significant variables was assessed using receiver operating characteristic analysis. Results: The invasion group of cervical cancer demonstrated significantly higher K trans (0.335 ± 0.050 vs. 0.269 ± 0.079; p < 0.001), lower energy values (0.503 ± 0.093 vs. 0.602 ± 0.087; p < 0.001), and higher entropy values (1.391 ± 0.193 vs. 1.24 ± 0.129; p < 0.001) than those in the non-invasion group. Optimal diagnostic performance [area under curve [AUC], 0.925; sensitivity, 0.935; specificity, 0.829] could be obtained by the combination of K trans , energy, and entropy values. The AUC values of K trans (0.788), energy (0.761), entropy (0.749), the combination of K trans and energy (0.814), the combination of K trans and entropy (0.727), and the combination of energy and entropy (0.619) were lower than those of the combination of K trans , energy, and entropy values. Conclusion: The combination of DCE-MRI and texture analysis is a promising method for diagnosis cervical cancer with parametrial infiltration. Moreover, the combination of K trans , energy, and entropy is more valuable than any one alone, especially in improving diagnostic sensitivity.

Amide proton transfer weighted imaging combined with dynamic contrast-enhanced MRI in predicting lymphovascular space invasion and deep stromal invasion of IB1-IIA1 cervical cancer

“…( 35 ) and Li et al. ( 36 ) studied the relationship between parametrial invasion, a high-risk factor for cervical cancer, and DCE-MRI parameters, and found that the quantitative parameter values ​​of primary lesions in the infiltrating group were significantly higher than those in the non-infiltrating group. This was similar to the results of the present study.…”

Magnetic resonance imaging in cervical cancer: current opportunities of radiomics analysis and prospects for its further developmen

“…the rate constant, K ep ) и внеклеточное объемное соотношение (англ. extracellular volume, V e ) [59]. В результате ROC-анализа были установлены пороговые значения (cut-off) для наиболее информативных визуализационных и текстурных показателей для оценки параметральной инвазии: пороговое значение K trans ≥ 0,286 мин -1 может стать оптимальным порогом для установления вовлеченности в процесс параметральной клетчатки и использоваться в клинической практике (AUC = 0,788; чувствительность = 0,839; специфичность = 0,657).…”

“…По своей диагностической эффективности она превзошла комбинированное использование K trans + Энергия (AUC = 0,727, чувствительность = 0,806, специфичность = 0,657) и Энтропия + Энергия (AUC = 0,619, чувствительность = 0,548, специфичность = 0,771, соответственно). Наиболее информативной в оценке инвазии явилась комбинация всех трех параметров -K trans + Энтропия + Энергия (AUС = 0,925, чувствительность = 0,935, специфичность = 0,829), что обосновывает сочетанное применение мультипараметрической МРТ и текстурного анализа в рамках предоперационного обследования пациенток [59].…”

Efficacy and safety of Buzhong Yiqi Decoction in improving cancer-related fatigue and immunity of cervical carcinoma patients

“…It is a common malignant tumor all over the world, with a high incidence, which has seriously affected women's physical and mental health. [1,2] In recent years, chemotherapy has gradually become one of prior treatment methods for cervical carcinoma. [3][4][5] It has been reported that low-dose chemotherapeutics could increase the sensitivity of radiotherapy in cervical carcinoma patients.…”

“…Cervical carcinoma, a malignant tumor that develops in the cervix, is mainly related to long-term infection. It is a common malignant tumor all over the world, with a high incidence, which has seriously affected women's physical and mental health [1,2] . In recent years, chemotherapy has gradually become one of prior treatment methods for cervical carcinoma [3–5] .…”