Diagnosis of canine pulmonary thromboembolism by computed tomography and mathematical modelling using haemostatic and inflammatory variables

Marschner, Clara B.; Kristensen, Annemarie T.; Rozanski, Elizabeth A.; McEvoy, Fintan J.; Kühnel, Line; Taeymans, Olivier; Laforcade, Armelle de; Sato, Amy F.; Wiinberg, Bo

doi:10.1016/j.tvjl.2017.10.010

Cited by 25 publications

(32 citation statements)

References 38 publications

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“…Thrombosis was documented in 6/52 dogs (11.5%) with adrenal gland tumors, in 4 of 41 dogs that died in a large retrospective study of dogs undergoing splenectomy for splenic masses . In a prospective study evaluating the use of CT scanning to identify PTE, 3/6 dogs with PTE had underlying neoplasia …”

Section: Peco Question: Cancermentioning

confidence: 86%

“…Sepsis is consistently listed as an underlying cause of thrombosis in retrospective studies of thrombotic conditions in dogs, but most studies lack controls (LOE 5, Good) . Bacterial endocarditis, septic peritonitis, and aspiration pneumonia are commonly identified; however, the direct association between sepsis and thrombosis is complicated by the frequent presence of concurrent disease processes that also potentially affect hemostasis including immune‐mediated disease and neoplasia . Despite this, hemostatic alterations consistent with hypercoagulability have been identified in dogs similar to those seen in people including reduced endogenous anticoagulants (protein C 104 and antithrombin) increased fibrinogen, increased thrombin activatable fibrinolysis inhibitor, thrombomodulin downregulation, and platelet hyperreactivity …”

Section: Peco Question: Sepsismentioning

confidence: 99%

“…The predominance of deep vein thrombosis as a precursor to pulmonary embolism in people and of atherosclerosis as a precursor to arterial thrombosis further complicates our ability to directly extrapolate from the human literature, given that deep vein thrombosis and atherosclerosis are uncommon in veterinary medicine. Growing interest in hypercoagulability has led to the development of a body of veterinary literature describing thrombosis and use of antithrombotics in dogs and cats …”

Section: Introductionmentioning

confidence: 99%

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Consensus on the Rational Use of Antithrombotics in Veterinary Critical Care (CURATIVE): Domain 1—Defining populations at risk

deLaforcade

Bacek

Blais

et al. 2019

J Vet Emergen Crit Care

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Objectives:Thrombosis is a well-recognized phenomenon in dogs and cats with a significant impact on morbidity and mortality. Despite growing awareness of thrombosis and increased use of antithrombotic therapy, there is little information in the veterinary literature to guide the use of anticoagulant and antiplatelet medications. The goal of Domain 1 was to explore the association between disease and thrombosis in a number of conditions identified as potential risk factors in the current veterinary literature, to provide the basis for prescribing recommendations.Design: A population exposure comparison outcome format was used to represent patient, exposure, comparison, and outcome. Population Exposure Comparison Outcome questions were distributed to worksheet authors who performed comprehensive searches, summarized the evidence, and created guideline recommendations that were reviewed by domain chairs. Revised guidelines then underwent the Delphi survey process to reach consensus on the final guidelines.Diseases evaluated included immune-mediated hemolytic anemia, protein-losing nephropathy, pancreatitis, glucocorticoid therapy, hyperadrenocorticism, neoplasia, sepsis, cerebrovascular disease, and cardiac disease.Settings: Academic and referral veterinary medical centers.

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Section: Peco Question: Cancermentioning

confidence: 86%

Section: Peco Question: Sepsismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Consensus on the Rational Use of Antithrombotics in Veterinary Critical Care (CURATIVE): Domain 1—Defining populations at risk

deLaforcade

Bacek

Blais

et al. 2019

J Vet Emergen Crit Care

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“…Sepsis is a common disease process in retrospective studies of dogs with thrombosis, but most studies lack controls (LOE 5, Good‐Fair), and the direct association between sepsis and thrombosis is confounded by concurrent disease processes . Hemostatic alterations consistent with hypercoagulability have been identified in dogs with sepsis …”

Section: Guidelinesmentioning

confidence: 99%

American College of Veterinary Emergency and Critical Care (ACVECC) Consensus on the Rational Use of Antithrombotics in Veterinary Critical Care (CURATIVE) guidelines: Small animal

Goggs

Blais

Brainard

et al. 2019

J Vet Emergen Crit Care

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Objectives: To systematically review available evidence and establish guidelines related to the risk of developing thrombosis and the management of small animals with antithrombotics. Design: Standardized, systematic evaluation of the literature (identified by searching Medline via PubMed and CAB abstracts) was carried out in 5 domains (Defining populations at risk; Defining rational therapeutic use; Defining evidence-based protocols; Refining and monitoring antithrombotic therapies; and Discontinuing antithrombotic therapies). Evidence evaluation was carried out using Population, Intervention, Comparison, Outcome generated within each domain questions to address specific aims. This was followed by categorization of relevant articles according to level of evidence and quality (Good, Fair, or Poor). Synthesis of these data led to the development of a series of statements. Consensus on the final guidelines was achieved via Delphi-style surveys.Draft recommendations were presented at 2 international veterinary conferences and made available for community assessment, review, and comment prior to final revisions and publication. Settings: Academic and referral veterinary medical centers.Results: Over 500 studies were reviewed in detail. Worksheets from all 5 domains generated 59 statements with 83 guideline recommendations that were refined during 3 rounds of Delphi surveys. A high degree of consensus was reached across all guideline recommendations. Conclusions:Overall, systematic evidence evaluations yielded more than 80 recommendations for the treatment of small animals with or at risk of developing thrombosis. Numerous significant knowledge gaps were highlighted by the evidence reviews undertaken, indicating the need for substantial additional research in this field. K E Y W O R D S ) for their dedicated contributions to this effort. We would also like to thank the members of the veterinary community who attended and contributed to the discussion of the guidelines during the 2018 EVECC Congress and IVECCS sessions and subsequently during the online open-comment stages. CONFLICT OF INTERESTThe authors declare that they have no conflicts of interest.

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“…For monitoring the thromboembolic status, we focused on D-dimer, antithrombin (AT), and thrombin-antithrombin complex (TAT). D-dimer is a degradation product of cross-linked fibrin, reflecting the level of fibrinolysis [19]. AT is one of the thrombin-binding proteins and its depletion is associated with the mortality in various diseases with thromboembolisms [17].…”

mentioning

confidence: 99%

Treatment with rivaroxaban and monitoring of coagulation profiles in two dogs with venous thromboembolism

Uchida

Ohmi

Fujiwara

et al. 2020

The Journal of Veterinary Medical Science

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Two dogs with immune-mediated hemolytic anemia complicated with thromboembolism were presented. Both of the dogs were initially treated with immunosuppressive therapy in conjunction with dalteparin and clopidogrel. Although the immunosuppressive therapy was effective, peritoneal effusion due to thromboembolism was observed during the course of the disease in these dogs. After initiation of rivaroxaban treatment, peritoneal effusion decreased immediately in parallel with the normalization of D-dimer, antithrombin (AT), and thrombin-antithrombin complex (TAT). Hematochezia, cutaneous hemorrhage, and hematuria were observed as adverse events after administration of rivaroxaban in one case. Rivaroxaban was effective for the control of thromboembolism secondary to immune-mediated hemolytic anemia, and D-dimer, AT, and TAT were useful to monitor the status of thromboembolic disease in dogs.

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Diagnosis of canine pulmonary thromboembolism by computed tomography and mathematical modelling using haemostatic and inflammatory variables

Cited by 25 publications

References 38 publications

Consensus on the Rational Use of Antithrombotics in Veterinary Critical Care (CURATIVE): Domain 1—Defining populations at risk

Consensus on the Rational Use of Antithrombotics in Veterinary Critical Care (CURATIVE): Domain 1—Defining populations at risk

American College of Veterinary Emergency and Critical Care (ACVECC) Consensus on the Rational Use of Antithrombotics in Veterinary Critical Care (CURATIVE) guidelines: Small animal

Treatment with rivaroxaban and monitoring of coagulation profiles in two dogs with venous thromboembolism

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