Diagnosis of Calcium Pyrophosphate Dihydrate Deposition Disease by Fine Needle Aspiration Biopsy

Pakzad, Kourosh; Yang, Yi; Ambrose, J. Lee; Landas, Steve K.

doi:10.1159/000326715

Cited by 6 publications

(24 citation statements)

References 10 publications

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“…The role of FNA in diagnosis of CPPD has been described in the neck[ 7 , 8 ] vertebral body[ 9 ], other joints (ankle, metatarso-phalangeal, knee)[ 10 ], surrounding soft tissue[ 10 ], and paraischial soft tissue mass[ 11 ]. (Table 1 ) The aspirated crystals may be intracellular or extracellular [ 7 - 10 ].…”

Section: Discussionmentioning

confidence: 99%

Calcium pyrophosphate dihydrate deposition disease (CPPD)/Pseudogout of the temporomandibular joint – FNA findings and microanalysis

Naqvi¹,

Abraham²,

Kellman³

et al. 2008

CytoJournal

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We report a case of a Calcium pyrophosphate dihydrate deposition disease (CPPD) presenting as a mass in the parotid and temporomandibular joint (TMJ) that simulated a parotid tumor. A 35 year-old man presented with pain in the left ear area. A CT Scan of the area showed a large, calcified mass surrounding the left condylar head, and extending into the infratemporal fossa. FNA of the mass showed birefringent crystals, most of which were rhomboid with occasional ones being needle shaped, embedded in an amorphous pink substance. Scanning electron microscopy (SEM) with energy dispersive x-ray spectroscopy (EDS) of these crystals showed peaks corresponding to calcium and phosphorus. SEM/EDS is a rapid method of diagnosing calcium pyrophosphate dihydrate deposition disease (CPPD) and an alternative to more commonly used method of special staining of cell block sections coupled with polarizing microscopy.

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Section: Discussionmentioning

confidence: 99%

Calcium pyrophosphate dihydrate deposition disease (CPPD)/Pseudogout of the temporomandibular joint – FNA findings and microanalysis

Naqvi¹,

Abraham²,

Kellman³

et al. 2008

CytoJournal

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“…Diagnosis of arthropathy induced by CPPD crystals is primarily based on microscopic identification of crystals in synovial fluid, 3 but they usually demonstrate a weakly positive birefringence under polarized microscopy and can be easily missed. [4][5][6] We here report a highly characteristic case of CPPD crystals-induced arthritis diagnosed on microscopic examination of the synovial fluid.…”

Section: To the Editorsmentioning

confidence: 91%

“…2,3 Identification of CPPD crystals provides an alternative cause in cases in which clinical manifestations of infectious diseases are suggested yet unproven. 5 The natural course of CPPD arthritis is spontaneous resolution over a few days or weeks. Treatment accelerates recovery and includes modified activity, physical therapy and NSAIDs.…”

Section: To the Editorsmentioning

confidence: 99%

Calcium Pyrophosphate Dihydrate Crystal–Induced Arthritis: Diagnosis by Synovial Fluid Examination

Galed-Placed¹,

Carro-Rey²

2009

Acta Cytologica

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“…The role of FNA in diagnosis of CPPD has been described in the neck 5 vertebral Body, 9 other joints (ankle, metatarso-phalangeal, knee), 10 surrounding soft Tissue, 10 and paraischial soft tissue mass. 11 The aspirated crystals may be intracellular or extracellular.…”

Section: 3mentioning

confidence: 99%

Tumoral calcium pyrophosphate dihydrate crystal deposition disease: A rare diagnosis by fine‐needle aspiration

Kishore

Khare

Gupta

et al. 2009

Diagnostic Cytopathology

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Calcium pyrophosphate dihydrate crystal deposition disease (CPPD) is a well-recognized inflammatory joint disorder characterized by presence of calcium pyrophosphate dihydrate crystals in intraarticular and periarticular tissue. We report here a case of a 48-year-old male who presented with painless right hand swelling. Clinical suspicion was that of malignant soft tissue tumor. Fine-needle aspiration (FNA) yielded chalky white gritty material. Microscopic examination showed large areas of basophilic calcified material, histiocytes, giant cells and characteristic rhomboid shaped crystals. At places, chondroid material was also identified, hence, diagnosis of CPPD was made. This was confirmed on histopathological examination. Tophaceous/ tumoral pseudogout is a rare form of CPPD and it is important to recognize that this form can be diagnosed in FNA cytology (FNAC) and misdiagnosis of benign or malignant cartilaginous lesions can be avoided.

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Diagnosis of Calcium Pyrophosphate Dihydrate Deposition Disease by Fine Needle Aspiration Biopsy

Cited by 6 publications

References 10 publications

Calcium pyrophosphate dihydrate deposition disease (CPPD)/Pseudogout of the temporomandibular joint – FNA findings and microanalysis

Calcium pyrophosphate dihydrate deposition disease (CPPD)/Pseudogout of the temporomandibular joint – FNA findings and microanalysis

Calcium Pyrophosphate Dihydrate Crystal–Induced Arthritis: Diagnosis by Synovial Fluid Examination

Tumoral calcium pyrophosphate dihydrate crystal deposition disease: A rare diagnosis by fine‐needle aspiration

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