Diagnosis of bone metastases: a meta-analysis comparing 18FDG PET, CT, MRI and bone scintigraphy

Yang, Huilin; Liu, Tao; Wang, Ximing; Xu, Yong; Deng, Shengming

doi:10.1007/s00330-011-2221-4

Cited by 315 publications

(209 citation statements)

References 78 publications

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“…Differences in the incidence of osteoblastic bony lesions or in the study design may account for such discrepancies. A recent metaanalysis found that the reported sensitivities of 18 F-FDG PET in various types of tumors ranged from 45% to 95% (9). We have previously reported that 18 F-FDG PET had a sensitivity of 70% for detecting bony metastases of nasopharyngeal carcinoma (13).…”

Section: Discussionmentioning

confidence: 91%

“…In contrast, 18 F-FDG PET/CT is superior to 99m Tc-MDP bone scanning in the detection of osteolytic or bone marrow metastases (6,7). Because 18 F-FDG PET/CT allows for the simultaneous assessment of local, regional, and distant sites of malignancy, there is active debate concerning the routine replacement of 99m Tc-MDP bone scanning with 18 F-FDG PET/CT for the detection of bony metastases (8,9).…”

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confidence: 99%

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Utility of¹⁸F-Fluoride PET/CT and¹⁸F-FDG PET/CT in the Detection of Bony Metastases in Heightened-Risk Head and Neck Cancer Patients

Chan

Wang

et al. 2012

J Nucl Med

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This study compared the diagnostic accuracy of 18 F-FDG PET/CT with that of 18 F-fluoride PET/CT in the detection of bony metastases in heightened-risk head and neck cancer patients. Methods: The study participants underwent 18 F-FDG PET/CT and 18 F-fluoride PET/CT within 2 wk of each another. Results: A total of 98 bony metastases were found in 18 of our 80 patients. 18 F-fluoride PET/CT and 18 F-FDG PET/CT showed similar lesion-based sensitivity (69.4% vs. 57.1%, P 5 0.126) and areas under the curve (0.7561 vs. 0.7959, P 5 0.149). Their combined interpretation demonstrated a significantly greater sensitivity and areas under the curve than that obtained with either modality alone (P , 0.001) in lesion-based analysis but not in patient-based analysis, with a treatment strategy change in 2 patients. Conclusion: 18 F-fluoride PET/CT is a feasible modality for detecting bony metastases in patients with head and neck cancers, with similar sensitivity to 18 F-FDG PET/CT. Their combined use may not be justifiable.

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Section: Discussionmentioning

confidence: 91%

mentioning

confidence: 99%

Utility of¹⁸F-Fluoride PET/CT and¹⁸F-FDG PET/CT in the Detection of Bony Metastases in Heightened-Risk Head and Neck Cancer Patients

Chan

Wang

et al. 2012

J Nucl Med

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“…9 They have also been combined with the redox proteins glucose oxidase 7 and cytochrome c 10 in biosensors for glucose and nitric oxide, respectively. Graphene paper electrodes have been used in lithium batteries, 17 and graphene oxide has been incorporated into a glucose biosensor. 18 Recently, Qu et al 19 used nitrogen-doped graphene, produced using chemical vapour deposition, to promote oxygen reduction in fuel cells.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical ascorbic acid sensor based on DMF-exfoliated graphene

et al. 2010

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This paper describes the electron transfer properties of graphene nano-sheets (GNSs) immobilised on pyrolysed photoresist film (PPF) electrodes. The former are produced by the dispersion and exfoliation of graphite in dimethylformamide, and they are characterised using transmission electron microscopy, scanning electron microscopy and Raman spectroscopy. Cyclic voltammetry and electrochemical impedance spectroscopy are used to quantify the effect of the GNSs on electrochemical surface area and on electron transfer kinetics. Compelling evidence is reported in relation to the importance of edgeplane sites and defects in the promotion of electron transfer at carbon nanostructures. A novel ascorbic acid (vitamin C) sensor is presented based on the PPF/GNS system, which is effective in the range 0.4 to 6.0 mM, with a 0.12 mM detection limit. The selectivity of the sensor is demonstrated using a commercially available vitamin C supplement. This is the first report of the electrochemical properties of graphene nano-sheets produced using liquid-phase exfoliation, and it will serve as an important benchmark in the development of inexpensive graphene-based electrodes with high surface area and electro-catalytic activity.

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“…Whole-body MR imaging has been shown to have superior diagnostic accuracy compared with CT and bone scintigraphy in detection of bone metastases because of its ability to assess early infiltration of bone marrow that precedes osteoblastic and osteoclastic response of the bone matrix to malignant tissue infiltration [4,2,[5][6][7]. The comparison of whole-body MR and PET/CT for the detection of bone metastases in solid tumours and haematological malignancies yielded heterogeneous results depending on the tumour histology and the PET tracer used [8][9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

18F-FDG-PET/MR increases diagnostic confidence in detection of bone metastases compared with 18F-FDG-PET/CT

Samarin

Hüllner

Queiroz

et al. 2015

Nuclear Medicine Communications

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PURPOSE: The aim of this study was to compare detection, lesion conspicuity and reader confidence of F-fluorodeoxyglucose (F-FDG)-PET/MR and F-FDG-PET/computed tomography (CT) in patients with F-FDG avid bone metastases. MATERIALS AND METHODS: In this prospective study, a total of 30 PET/CT and PET/MRI data sets were performed in 24 patients. Each examination was evaluated for the presence of PET-positive bone lesions consistent with metastatic involvement. Conspicuity of PET-positive bone lesions was evaluated on the corresponding PET/CT and PET/MR images and compared using the Wilcoxon signed-ranks test. Reader confidence was determined to evaluate whether PET/CT or PET/MR was more useful for the assessment of the bone metastases and was compared using Student's t-test. RESULTS: Overall, in both examinations, PET/CT and PET/MRI detected 86 F-FDG-positive bone lesions. On all 30 PET/MRI examinations, at least one morphological correlate for F-FDG-positive bone lesions was found on the MR component (82 out of 86 lesions). PET/CT imaging allowed identification of corresponding structural changes on the CT component in 23 out of 30 studies (65 out of 86 lesions). In lesion-by-lesion analysis, the mean lesion conspicuity was significantly better on T1 fat MR imaging compared with CT imaging (P=0.005). In seven out of 30 studies, a significant increase in reader confidence of PET/MRI compared with PET/CT was found. CONCLUSION: PET/MRI offers higher reader confidence and improved conspicuity in bone metastases compared with PET/CT. However, the overall detection rate was not different. The highest possible clinical impact of PET/MRI appears to be in patients with limited, early bone metastatic disease. Materials and methods In this prospective study, a total of 30 PET/CT and PET/MRI data sets were performed in 24 patients. Each examination was evaluated for the presence of PET-positive bone lesions consistent with metastatic involvement. Conspicuity of PET-positive bone lesions was evaluated on the corresponding PET/CT and PET/MR images and compared using the Wilcoxon signed-ranks test. Reader confidence was determined to evaluate whether PET/CT or PET/MR was more useful for the assessment of the bone metastases and was compared using Student's t-test. In lesion-by-lesion analysis, the mean lesion conspicuity was significantly better on T1 fat MR imaging compared with CT imaging (P = 0.005). In seven out of 30 studies, a significant increase in reader confidence of PET/MRI compared with PET/CT was found.Conclusion PET/MRI offers higher reader confidence and improved conspicuity in bone metastases compared with PET/CT. However, the overall detection rate was not different. The highest possible clinical impact of PET/MRI appears to be in patients with limited, early bone metastatic disease. Nucl Med Commun 00:000-000

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Diagnosis of bone metastases: a meta-analysis comparing 18FDG PET, CT, MRI and bone scintigraphy

Abstract: PET and MRI were found to be comparable and both significantly more accurate than CT and BS for the diagnosis of bone metastases.

Cited by 315 publications

References 78 publications

Utility of¹⁸F-Fluoride PET/CT and¹⁸F-FDG PET/CT in the Detection of Bony Metastases in Heightened-Risk Head and Neck Cancer Patients

Utility of¹⁸F-Fluoride PET/CT and¹⁸F-FDG PET/CT in the Detection of Bony Metastases in Heightened-Risk Head and Neck Cancer Patients

Electrochemical ascorbic acid sensor based on DMF-exfoliated graphene

18F-FDG-PET/MR increases diagnostic confidence in detection of bone metastases compared with 18F-FDG-PET/CT

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Diagnosis of bone metastases: a meta-analysis comparing 18FDG PET, CT, MRI and bone scintigraphy

Abstract: PET and MRI were found to be comparable and both significantly more accurate than CT and BS for the diagnosis of bone metastases.

Cited by 315 publications

References 78 publications

Utility of18F-Fluoride PET/CT and18F-FDG PET/CT in the Detection of Bony Metastases in Heightened-Risk Head and Neck Cancer Patients

Utility of18F-Fluoride PET/CT and18F-FDG PET/CT in the Detection of Bony Metastases in Heightened-Risk Head and Neck Cancer Patients

Electrochemical ascorbic acid sensor based on DMF-exfoliated graphene

18F-FDG-PET/MR increases diagnostic confidence in detection of bone metastases compared with 18F-FDG-PET/CT

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Utility of¹⁸F-Fluoride PET/CT and¹⁸F-FDG PET/CT in the Detection of Bony Metastases in Heightened-Risk Head and Neck Cancer Patients

Utility of¹⁸F-Fluoride PET/CT and¹⁸F-FDG PET/CT in the Detection of Bony Metastases in Heightened-Risk Head and Neck Cancer Patients