Diagnosis of bladder carcinoma using protoporphyrin IX fluorescence induced by 5‐aminolaevulinic acid

Koenig, Frank; McGovern, Francis J.; Larne, Rickard; Enquist, Henrik; Schomacker, Kevin T.; Deutsch, Thomas F.

doi:10.1046/j.1464-410x.1999.00917.x

Cited by 115 publications

(62 citation statements)

References 19 publications

(37 reference statements)

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“…b Sex. This section sums to 2813 rather than 2807 because the study by Koenig and colleagues 67 reported gender information for those enrolled (n = 55) rather than those analysed (n = 49).…”

Section: Figurementioning

confidence: 99%

“…In two 72,78 of these studies the whole patient population (n = 102) had a suspicion of bladder cancer and in three 51,58,84 the whole population had previously diagnosed bladder cancer (n = 117). The remaining eight studies 50,52,54,56,67,73,76,85 did not report this information. In total, 18 50,53,54,56,58,59,[61][62][63]67,[70][71][72][73]77,78,84,85 (67%) of 27 studies used 5-ALA as the photosensitising agent, five 57,60,65,66,81 (19%) used HAL, two 52,76 (7%) used hypericin and two 51,80 used either 5-ALA or HAL but did report the number of patients receiving each agent.…”

Section: Figurementioning

confidence: 99%

“…Across 20 studies 50,51,53,56,57,[59][60][61][62][63][65][66][67]70,71,76,77,80,81,84 providing information on patient age, the median (range) of means was 67 years (52-72 years). In total, 18 studies 50,53,54,57,[60][61][62][63][65][66][67]70,71,76,77,80,81,84 provided information on the gender of 2157 participants, of whom 1647 (76%) were men and 510 (24%) were women.…”

Section: Figurementioning

confidence: 99%

“…In total, 18 studies 50,53,54,57,[60][61][62][63][65][66][67]70,71,76,77,80,81,84 provided information on the gender of 2157 participants, of whom 1647 (76%) were men and 510 (24%) were women.…”

Section: Figurementioning

confidence: 99%

“…However, in only 55% (15/27) of studies [50][51][52][53][54][57][58][59][60]63,65,67,70,72,84 were patients considered to have received the same reference standard regardless of the PDD test result. This question was checked 'yes' if random biopsies were taken from normal-appearing areas (i.e.…”

Section: Quality Of the Included Studiesmentioning

confidence: 99%

See 4 more Smart Citations

Systematic review of the clinical effectiveness and cost-effectiveness of photodynamic diagnosis and urine biomarkers (FISH, ImmunoCyt, NMP22) and cytology for the detection and follow-up of bladder cancer

Campbell

Skea²,

Sutherland³

et al. 2010

Health Technol Assess

249

207

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How to obtain copies of this and other HTA programme reports An electronic version of this title, in Adobe Acrobat format, is available for downloading free of charge for personal use from the HTA website (www.hta.ac.uk). A fully searchable DVD is also available (see below).Printed copies of HTA journal series issues cost £20 each (post and packing free in the UK) to both public and private sector purchasers from our despatch agents.Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per issue and for the rest of the world £3 per issue. How to order:-fax (with credit card details) -post (with credit card details or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you to either print out your order or download a blank order form. Contact details are as follows:Synergie UK (HTA Department) Digital House, The Loddon Centre Wade Road Basingstoke Hants RG24 8QW Email: orders@hta.ac.uk Tel: 0845 812 4000 -ask for 'HTA Payment Services' (out-of-hours answer-phone service) Fax: 0845 812 4001 -put 'HTA Order' on the fax header Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to University of Southampton and drawn on a bank with a UK address. Paying by credit cardYou can order using your credit card by phone, fax or post. SubscriptionsNHS libraries can subscribe free of charge. Public libraries can subscribe at a reduced cost of £100 for each volume (normally comprising 40-50 titles). The commercial subscription rate is £400 per volume (addresses within the UK) and £600 per volume (addresses outside the UK). Please see our website for details. Subscriptions can be purchased only for the current or forthcoming volume. How do I get a copy of HTA on DVD?Please use the form on the HTA website (www.hta.ac.uk/htacd/index.shtml). HTA on DVD is currently free of charge worldwide.The website also provides information about the HTA programme and lists the membership of the various committees. NIHR Health Technology Assessment programmeT he Health Technology Assessment (HTA) programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care. The research findings from the HTA programme directly influence decision-making bodies such as the National Institute for Health and Clinical Excellence (NICE) and the National Screening Committee (NSC). HTA findings also help to improve the quality of clinical practice in the NHS indirectly in that they form a key component of the 'National Knowledge Service'. The HTA programme is needs led in that it fills gaps in the evidence needed by the NHS. There are three routes to the start of projects. F...

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Section: Figurementioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Section: Quality Of the Included Studiesmentioning

confidence: 99%

See 3 more Smart Citations

Systematic review of the clinical effectiveness and cost-effectiveness of photodynamic diagnosis and urine biomarkers (FISH, ImmunoCyt, NMP22) and cytology for the detection and follow-up of bladder cancer

Campbell

Skea²,

Sutherland³

et al. 2010

Health Technol Assess

249

207

View full text Add to dashboard Cite

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Novel endoscopic techniques for the detection of bladder cancer

2015

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Role of 5‐aminolevulinic acid in the detection of urothelial premalignant lesions

Zaak

Hungerhuber

Schneede

et al. 2002

Cancer

112

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BACKGROUND The authors evaluated the role of 5‐aminolevulinic acid (5‐ALA)‐induced fluorescence endoscopy (AFE) in the detection of flat urothelial lesions in light of the suggestions made for flat neoplastic lesions within the 1999 World Health Organization (WHO) classification of urinary bladder tumors. METHODS From 1995 to 2000, 713 patients underwent 1414 AFE procedures for the detection of transitional cell carcinoma of the bladder (TCCB). Fluorescence imaging was performed with an incoherent light source (D‐light; 380–440 nm) that was filtered for efficient protoporphyrin IX excitation and with cystoscopes partially blocking reflected excitation light to enable fluorescence evaluation by a red/blue color contrast 2–3 hours after 50 mL of a 3% solution of 5‐ALA was instilled into the bladder. In total, 3834 biopsy specimens (mean, 2.7 specimens per AFE procedure) were taken. RESULTS Malignant disease was found in 1250 (32.6%) of all biopsies, with 304 biopsies (24.3%) showing carcinoma in situ (cis) and dysplasia II° (dys II) according to the previous diagnostic criteria of the WHO. Under prior conventional white‐light endoscopy, 30.3% of specimens with dys II and 52.8% of specimens with cis had been missed. CONCLUSIONS The current results suggest that 5‐ALA may be more effective in the detection of flat urothelial lesions than the current diagnostic devices. Cancer 2002;95:1234–8. © 2002 American Cancer Society. DOI 10.1002/cncr.10821

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Diagnosis of bladder carcinoma using protoporphyrin IX fluorescence induced by 5‐aminolaevulinic acid

Cited by 115 publications

References 19 publications

Systematic review of the clinical effectiveness and cost-effectiveness of photodynamic diagnosis and urine biomarkers (FISH, ImmunoCyt, NMP22) and cytology for the detection and follow-up of bladder cancer

Systematic review of the clinical effectiveness and cost-effectiveness of photodynamic diagnosis and urine biomarkers (FISH, ImmunoCyt, NMP22) and cytology for the detection and follow-up of bladder cancer

Novel endoscopic techniques for the detection of bladder cancer

Role of 5‐aminolevulinic acid in the detection of urothelial premalignant lesions

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