Diagnosis of autoimmune skin disease in the dog: Correlation between histopathologic, direct immunofluorescent and clinical findings

Werner, Linda; Brown, Kara; Halliwell, R.E.W.

doi:10.1016/0165-2427(83)90031-4

Cited by 51 publications

(50 citation statements)

References 10 publications

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“…Tumour‐unrelated diseases that may cause claw changes include erythema multiforme, lupoid onychodystrophy and autoimmune diseases, such as bullous pemphigoid, acquired bullous epidermolysis, pemphigus vulgaris and systemic lupus erythematosus (Conroy 1983, Werner and others 1983, Gross and others 2005). Although no immune profile was included in the dogs’ workup, immune‐mediated diseases were ruled out based on clinical presentation, meaning the exclusiveness of claw changes without any other dermatological lesions or systemic symptoms.…”

Section: Discussionmentioning

confidence: 99%

Unusual dermatological toxicity of hydroxyurea in two dogs with spontaneously occurring tumours

Marconato¹,

Bonfanti²,

Fileccia³

2007

J of Small Animal Practice

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Hydroxyurea is a chemotherapeutic agent used to treat hypereosinophilic syndrome, mast cell tumours and many myeloproliferative disorders. It is usually well tolerated; however, reported side effects include myelosuppression and gastrointestinal complications as well as cutaneous toxicity, in very rare cases. We report the unusual appearance of onychomadesis involving several claws on all feet in two canine patients receiving long-term hydroxyurea treatment. The healing of nail lesions required cessation of treatment in one dog and dose reduction in the second animal, supporting a strict relationship between onychopathy and administration of hydroxyurea. The aim of this case report is to increase clinical awareness of dermatological toxicity associated with long-term administration of hydroxyurea.

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Section: Discussionmentioning

confidence: 99%

Unusual dermatological toxicity of hydroxyurea in two dogs with spontaneously occurring tumours

Marconato¹,

Bonfanti²,

Fileccia³

2007

J of Small Animal Practice

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“…5 Since 1976, anecdotal cases of dogs with blistering and erosive diseases associated with basement membrane-specific autoantibodies have been reported under the umbrella diagnosis of BP. 2,4,[9][10][11]14,15,20,28,[31][32][33][35][36][37] In these cases, the specific antigen(s) targeted by autoantibodies, however, was not determined. In 1995, the canine homologue of human BP was established with the demonstration of anti-BP180 autoimmunity in a dog with cutaneous vesicles.…”

mentioning

confidence: 99%

Novel Feline Autoimmune Blistering Disease Resembling Bullous Pemphigoid in Humans: IgG Autoantibodies Target the NC16A Ectodomain of Type XVII Collagen (BP180/BPAG2)

Olivry

Chan

et al. 1999

Vet Pathol

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Abstract. In humans and dogs, bullous pemphigoid (BP) is an autoimmune blistering disease associated with the production of basement membrane autoantibodies that target the 180-kd type XVII collagen (BP180, BPAG2) and/or the 230-kd plakin epidermal isoform BPAG1e (BP230). In two adult cats, an acquired dermatosis and stomatitis was diagnosed as BP subsequent to the fulfillment of the following criteria: 1) presence of cutaneous vesicles, erosions, and ulcers; 2) histologic demonstration of subepidermal vesiculation with inflammatory cells, including eosinophils; 3) in vivo deposition of IgG autoantibodies at the epidermal basement membrane zone; and 4) serum IgG autoantibodies targeting a 180-kd epidermal protein identified as type XVII collagen. In both cats, the antigenic epitopes targeted by IgG autoantibodies were shown to be situated in the NC16A ectodomain of type XVII collagen, a situation similar to that of humans and dogs with BP. Feline BP therefore can be considered a clinical, histopathologic, and immunologic homologue of BP in humans and dogs.Key words: Autoimmunity; BP180; BPAG2; cats; collagen XVII; epidermal basement membrane; pemphigoid; skin.In humans, the binding of autoantibodies to glycoproteins located in the epidermal basement membrane zone often results in cutaneous blistering. 23 Based on immunochemical and molecular characterization of targeted autoantigens, the nosology of human vesicobullous diseases currently is being revised. The denomination of bullous pemphigoid (BP) presently is restricted to those blistering dermatoses characterized by inflammatory skin blisters, microscopical neutrophil-and eosinophil-rich subepidermal vesicles, and autoantibodies that target one or both BP antigens. These antigens consist of the following hemidesmosomal proteins: a 230-kd plakin epidermal isoform (BPAG1e, BP230) and/or the 180-kd transmembrane type XVII collagen (BPAG2, BP180). 3 BP is the most common autoimmune subepidermal bullous dermatosis of humans; it is the diagnosis achieved in ϳ70% of patients exhibiting antibasement membrane autoantibodies. 5 Since 1976, anecdotal cases of dogs with blistering and erosive diseases associated with basement membrane-specific autoantibodies have been reported under the umbrella diagnosis of BP. 2,4,[9][10][11]14,15,20,28,[31][32][33][35][36][37] In these cases, the specific antigen(s) targeted by autoantibodies, however, was not determined. In 1995, the canine homologue of human BP was established with the demonstration of anti-BP180 autoimmunity in a dog with cutaneous vesicles. 17 The immunologic identity of canine and human BP was further strengthened with the recent demonstration that in both species circulating IgG autoantibodies target similar antigenic epitopes in the NC16A ectodomain of type XVII collagen (BP180). 7 However, during the last 20 years, feline cases of blistering dermatoses associated with antibasement membrane autoantibodies have not been reported.The purpose of the present study was to demonstrate the existence of the feline coun...

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“…The clinical features were almost identical to autoimmune subepidermal blistering disease (Werner et al 1983;Olivery et al 2001). BP in dogs affects mainly the face and the ventral aspect of the body and, less frequently, the mucous membranes (Scott et al 1980;Favrot et al 2002).…”

mentioning

confidence: 75%

Subepidermal blistering disease in a 5-month-old Alaskan Malamute dog with concurrent megaesophagus

Kang

Seung

Lee

et al. 2013

Veterinary Quarterly

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Diagnosis of autoimmune skin disease in the dog: Correlation between histopathologic, direct immunofluorescent and clinical findings

Cited by 51 publications

References 10 publications

Unusual dermatological toxicity of hydroxyurea in two dogs with spontaneously occurring tumours

Unusual dermatological toxicity of hydroxyurea in two dogs with spontaneously occurring tumours

Novel Feline Autoimmune Blistering Disease Resembling Bullous Pemphigoid in Humans: IgG Autoantibodies Target the NC16A Ectodomain of Type XVII Collagen (BP180/BPAG2)

Subepidermal blistering disease in a 5-month-old Alaskan Malamute dog with concurrent megaesophagus

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