Diagnosis of Allergy and Asthma in Childhood

Baena-Cagnani, Carlos E.; Badellino, Héctor

doi:10.1007/s11882-010-0156-5

Cited by 20 publications

(29 citation statements)

References 46 publications

(63 reference statements)

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“…13 Various factors have been associated with an increased risk for asthma, including exposure to tobacco smoke, allergens, and food preservatives. [14][15][16] For example, sodium benzoate is a preservative used in sodas and foods, 17 and negative reactions (eg, cough and/or wheeze) to sodium benzoate have been reported among asthmatic children and adults. 18,19 Although two studies reported that asthma symptoms were worsened by drinking sodas, 15,19 one study among New Zealand children found no association between "fizzy drinks" and ever having asthma after adjusting for lifestyle factors.…”

mentioning

confidence: 99%

Regular-Soda Intake Independent of Weight Status Is Associated with Asthma among US High School Students

Park¹,

Blanck²,

Sherry³

et al. 2013

Journal of the Academy of Nutrition and Dietetics

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Limited research shows an inconclusive association between soda intake and asthma, potentially attributable to certain preservatives in sodas. This cross-sectional study examined the association between regular (nondiet)-soda intake and current asthma among a nationally representative sample of high school students. Analysis was based on the 2009 national Youth Risk Behavior Survey and included 15,960 students (grades 9 through 12) with data for both regular-soda intake and current asthma status. The outcome measure was current asthma (ie, told by doctor/nurse that they had asthma and still have asthma). The main exposure variable was regular-soda intake (ie, drank a can/bottle/glass of soda during the 7 days before the survey). Multivariable logistic regression was used to estimate the adjusted odds ratios for regular-soda intake with current asthma after controlling for age, sex, race/ethnicity, weight status, and current cigarette use. Overall, 10.8% of students had current asthma. In addition, 9.7% of students who did not drink regular soda had current asthma, and 14.7% of students who drank regular soda three or more times per day had current asthma. Compared with those who did not drink regular soda, odds of having current asthma were higher among students who drank regular soda two times per day (adjusted odds ratio = 1.28; 95% CI 1.02 to 1.62) and three or more times per day (adjusted odds ratio = 1.64; 95% CI 1.25 to 2.16). The association between high regular-soda intake and current asthma suggests efforts to reduce regular-soda intake among youth might have benefits beyond improving diet quality. However, this association needs additional research, such as a longitudinal examination. KeywordsSoda; Adolescents; Asthma; Youth Risk Behavior Survey (YRBS) Address correspondence to: Sohyun Park, PhD, Division of Nutrition, Physical Activity, and Obesity, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Mailstop K26, 4770 Buford Highway, NE, Atlanta, GA 30341. spark3@cdc.gov. STATEMENT OF POTENTIAL CONFLICT OF INTERESTNo potential conflict of interest was reported by the authors. During the last 30 years, the prevalence of asthma has increased and is currently one of the most common chronic diseases among US children and adolescents. 6 Self-reported asthma prevalence during the preceding 12 months in 1980 was 3.5%, whereas current asthma prevalence in 2004 was 8.5% among US youth aged younger than 18 years. 7 The most current data indicate that in 2009, >10 million US youth aged 17 years and younger (14%) had ever been diagnosed with asthma, and 7.1 million children still had asthma (10%). 6 In addition, in 2007, there were 640,000 emergency department visits and 157,000 hospitalizations for asthma in US youth aged 17 years and younger. 8 In the United States, asthma-related medical expenses, including lost school and work days and early deaths, were estimated at about $56 billion in 2007. 9 Evidence suggests that, among children, males...

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confidence: 99%

Regular-Soda Intake Independent of Weight Status Is Associated with Asthma among US High School Students

Park¹,

Blanck²,

Sherry³

et al. 2013

Journal of the Academy of Nutrition and Dietetics

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“…Differences between the study conducted by Yao et al and our current study could be attributed to the target population and assessment of atopy. Previous studies have described that age contributes to the variability of FeNO [4,5,8,18,20,25]. Our study had an older but narrower age range than the study by Yao et al (5-18 years).…”

Section: Discussionmentioning

confidence: 58%

“…Scott et al [18] reported a positive correlation between FeNO and the number of positive skin prick tests in a cohort of asthmatics. Previous studies have also correlated aeroallergen sensitization with FeNO levels in atopic children [7,13,16,19,20]. These findings underscore the relevance of evaluating allergen sensitization status when FeNO is used as a biomarker in the diagnosis and monitoring of asthma [18].…”

Section: Introductionmentioning

confidence: 55%

“…As per manufacturer's instructions, we recorded vertical and horizontal measurements of induration and erythema, alongside 0-2 scales of itchiness and pseudopodia 20 minutes after application. Atopy was defined as a positive skin response to any of the allergen specificities as previously described [16,20,26].…”

Section: Assessment Of Atopymentioning

confidence: 99%

“…The presence of a low to normal FeNO level in patients with chronic respiratory symptoms could also be helpful to rule out atopic status [20,22], however, there is a lack of strong evidence to support the role of FeNO in identifying atopy [2,5,11,[23][24][25]. One recent study by Yao et al reported that FeNO was a better marker of allergic sensitization than it was of asthma [17].…”

Section: Introductionmentioning

confidence: 99%

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Role Of Exhaled Nitric Oxide As A Predictor Of Atopy

Romero

Robinson

Baumann

et al. 2012

D39. Evaluation and Monitoring of Asthma and Copd

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Background: The fractional exhaled nitric oxide (FeNO) is a quantitative, noninvasive and safe measure of airways inflammation that may complement the assessment of asthma. Elevations of FeNO have recently been found to correlate with allergic sensitization. Therefore, FeNO may be a useful predictor of atopy in the general population. We sought to determine the diagnostic accuracy of FeNO in predicting atopy in a population-based study. Methods: We conducted a cross-sectional study in an age-and sex-stratified random sample of 13 to 15 year-olds in two communities in Peru. We asked participants about asthma symptoms, environmental exposures and sociodemographics, and underwent spirometry, assessment of FeNO and an allergy skin test. We used multivariable logistic regression to model the odds of atopy as a function of FeNO, and calculated area-under-the-curves (AUC) to determine the diagnostic accuracy of FeNO as a predictor of atopy. Results: Of 1441 recruited participants, 1119 (83%) completed all evaluations. Mean FeNO was 17.6 ppb (SD=0.6) in atopics and 11.6 ppb (SD=0.8) in non-atopics (p<0.001). In multivariable analyses, a FeNO>20 ppb was associated with an increase in the odds of atopy in non-asthmatics (OR=5.3, 95% CI 3.3 to 8.5) and asthmatics (OR=16.2, 95% CI 3.4 to 77.5). A FeNO>20 ppb was the best predictor for atopy with an AUC of 68% (95% CI 64% to 69%). Stratified by asthma, the AUC was 65% (95% CI 61% to 69%) in non-asthmatics and 82% (95% CI 71% to 91%) in asthmatics. Conclusions: FeNO had limited accuracy to identify atopy among the general population; however, it may be a useful indicator of atopic phenotype among asthmatics.

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Spirometric reference values in urban children in madagascar: Poverty is a risk factor for low lung function

Wolff¹,

Arison²,

Rahajamiakatra³

et al. 2013

Pediatric Pulmonology

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The equations established for school children in Madagascar's capital Antananarivo showed lung function values were lower than reference values for the same age group seen not only in European, but also in African American and African children. The unique ethnicity of the Malagasy people, which combines Southeast-Asian with substantial African influences, the heavy burden of pollution and poverty may explain these differences.

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Diagnosis of Allergy and Asthma in Childhood

Cited by 20 publications

References 46 publications

Regular-Soda Intake Independent of Weight Status Is Associated with Asthma among US High School Students

Regular-Soda Intake Independent of Weight Status Is Associated with Asthma among US High School Students

Role Of Exhaled Nitric Oxide As A Predictor Of Atopy

Spirometric reference values in urban children in madagascar: Poverty is a risk factor for low lung function

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