Diagnosis of advanced prostate cancer at the community level in Rwanda

Nzeyimana, Innocent; Nyirimodoka, Alexandre; Ngendahayo, Edouard; Bonane, Alex; Muhawenimana, Emmanuel; Umurangwa, Florence; Gasana, Africa; Sibomana, Alphonse Marie; Teplitsky, Seth; Rusatira, Christophe; Rickard, Jennifer; Hategekimana, Théobald; Rwamasirabo, Emile

doi:10.1007/s11255-021-02921-8

Cited by 7 publications

(10 citation statements)

References 26 publications

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“…We also found studies conducted in Ghana ( n = 6) ( 50 , 71 , 111 , 123 , 134 , 155 ), Kenya ( n = 5) ( 70 , 96 , 115 , 132 , 139 ), Zambia ( n = 4) ( 44 , 77 , 102 , 126 ), and Eritrea ( n = 3) ( 60 – 62 ). There were seven countries with two studies each [Botswana ( 43 , 47 ), the Central African Republic ( 31 , 32 ), Mozambique ( 57 , 58 ), Rwanda ( 130 , 136 ), Senegal ( 147 , 156 ), Sudan ( 84 , 114 ) and Zimbabwe ( 38 , 39 )]. The countries with a single study were Cote d'Ivoire ( 128 ), Democratic Republic of Congo ( 99 ), Mali ( 85 ), Swaziland ( 76 ), Tanzania ( 49 ), and The Gambia ( 30 ).…”

Section: Resultsmentioning

confidence: 99%

“…The two prevalence studies from Ghana consisted of a cross-sectional study ( 123 ) and a review ( 155 ). There was one study from each of the following countries: a retrospective record review of registry from Kenya ( 96 ), Uganda ( 59 ), a cross-sectional study from Cameroon ( 100 ), a retrospective record review of pathology reports from South Africa ( 80 ) and Zambia ( 44 ), a retrospective cohort study from Tanzania ( 49 ), a cross-sectional study from Rwanda ( 136 ). The two studies that reported on the whole of Africa ( 138 , 154 ) and two global studies including Africa ( 104 , 145 ).…”

Section: Resultsmentioning

confidence: 99%

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Mapping Evidence on the Burden of Breast, Cervical, and Prostate Cancers in Sub-Saharan Africa: A Scoping Review

Musekiwa

Moyo²,

Mohammed³

et al. 2022

Front. Public Health

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BackgroundCancer remains a major public health problem, especially in Sub-Saharan Africa (SSA) where the provision of health care is poor. This scoping review mapped evidence in the literature regarding the burden of cervical, breast and prostate cancers in SSA.MethodsWe conducted this scoping review using the Arksey and O'Malley framework, with five steps: identifying the research question; searching for relevant studies; selecting studies; charting the data; and collating, summarizing, and reporting the data. We performed all the steps independently and resolved disagreements through discussion. We used Endnote software to manage references and the Rayyan software to screen studies.ResultsWe found 138 studies that met our inclusion criteria from 2,751 studies identified through the electronic databases. The majority were retrospective studies of mostly registries and patient files (n = 77, 55.8%), followed by cross-sectional studies (n = 51, 36.9%). We included studies published from 1990 to 2021, with a sharp increase from 2010 to 2021. The quality of studies was overall satisfactory. Most studies were done in South Africa (n = 20) and Nigeria (n = 17). The majority were on cervical cancer (n = 93, 67.4%), followed by breast cancer (67, 48.6%) and the least were on prostate cancer (48, 34.8%). Concerning the burden of cancer, most reported prevalence and incidence. We also found a few studies investigating mortality, disability-adjusted life years (DALYs), and years of life lost (YLL).ConclusionsWe found many retrospective record review cross-sectional studies, mainly in South Africa and Nigeria, reporting the prevalence and incidence of cervical, breast and prostate cancer in SSA. There were a few systematic and scoping reviews. There is a scarcity of cervical, breast and prostate cancer burden studies in several SSA countries. The findings in this study can inform policy on improving the public health systems and therefore reduce cancer incidence and mortality in SSA.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Mapping Evidence on the Burden of Breast, Cervical, and Prostate Cancers in Sub-Saharan Africa: A Scoping Review

Musekiwa

Moyo²,

Mohammed³

et al. 2022

Front. Public Health

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“…These findings agree with the Rwandese and Nigerian study, which showed that most (85%) prostate cancer patients had an advanced and were locally advanced (88.9%) stage at the time of diagnosis, respectively. 16 , 24 Such differences may be due to differences in literacy level and health-seeking behaviour of patients.…”

Section: Discussionmentioning

confidence: 99%

Treatment Outcomes and Its Associated Factors Among Adult Patients with Selected Solid Malignancies at Kenyatta National Hospital: A Hospital-Based Prospective Cohort Study

Degu¹,

Terefe²,

Some³

et al. 2022

CMAR

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Introduction The treatment outcome of cancer is poor in the African setting due to inadequate treatment and diagnostic facilities. However, there is a paucity of data on solid cancers in Kenya. Hence, this study aimed to investigate the treatment outcomes and its determinant factors among adult patients diagnosed with selected solid malignancies at Kenyatta National Hospital (KNH). Materials and Methods A prospective cohort study was employed at the Oncology Department of KNH from 1 st July 2020 to 31 st December 2021. All new patients with a confirmed diagnosis of lymphoma, prostate cancer and breast cancer were studied. A consecutive sample of 99 breast cancer, 50 lymphomas, and 82 prostate cancer patients was included in the study. Semi-structured questionnaires consisting of socio-demographics, clinical characteristics, and quality of life were employed to collect the data. All enrolled patients were followed prospectively for 12 months. Treatment outcomes were reported as mortality, cancer-specific survival and health-related quality of life. The data were entered and analyzed using the SPSS 20.0 statistical software. Survival outcomes and its predictors were evaluated using the Kaplan–Meier analysis and Cox regression analyses, respectively. Results The study showed that the mortality rate among breast and prostate cancer patients was 3% and 4.9%, respectively. In contrast, the mortality rate was 10% among lymphoma patients. Most of the patients had partial remission and a good overall global health-related quality of life. Older age above 60 years, co-morbidity, distant metastasis and advanced stages of disease were significant predictors of mortality. Conclusion Although the mortality was not high at 12 months, only a few patients had complete remission. For many patients, the disease was progressing, despite 12-month mortality was not high. Therefore, longer follow-up will be required to report cancer mortality accurately. In addition, most of the patients had a good overall global health-related quality of life.

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“…Late presentation is common in Africa. [ 3 4 5 8 9 13 ] The reasons for this pattern of presentation lie in the peculiarities of this subregion; lack of comprehensive health insurance, illiteracy, and poverty. [ 2 13 14 ] Public health expenditure is about $8 per capita, compared with the recommended $34.…”

Section: Discussionmentioning

confidence: 99%

“…[ 3 ] The majority of the patients with CaP in Nigeria and Africa present late with advanced disease. [ 3 4 5 ] Hormonal treatment by way of bilateral orchidectomy is the most common treatment offered to these patients in this subregion. [ 3 4 6 ]…”

Section: Introductionmentioning

confidence: 99%

Prostate cancer and challenges in management in a semi-urban centre: A 10-year experience

Okeke

Okwudili

Ojewola

et al. 2022

J West Afr Coll Surg

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Diagnosis of advanced prostate cancer at the community level in Rwanda

Cited by 7 publications

References 26 publications

Mapping Evidence on the Burden of Breast, Cervical, and Prostate Cancers in Sub-Saharan Africa: A Scoping Review

Mapping Evidence on the Burden of Breast, Cervical, and Prostate Cancers in Sub-Saharan Africa: A Scoping Review

Treatment Outcomes and Its Associated Factors Among Adult Patients with Selected Solid Malignancies at Kenyatta National Hospital: A Hospital-Based Prospective Cohort Study

Prostate cancer and challenges in management in a semi-urban centre: A 10-year experience

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