Diagnosis of Acute Herpes Simplex Encephalitis by Brain Perfusion Single Photon Emission Computed Tomography

Launes, Jyrki; Lindroth, L.; Liewendahl, K.; Nikkinen, Päivi; Brownell, Anna‐Liisa; Iivanainen, Matti

doi:10.1016/s0140-6736(88)92010-7

Cited by 84 publications

(40 citation statements)

References 15 publications

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“…In contrast to the study of Launes et al [9] the present in vivo experiments, using an animal model, reveal no significant difference in brain uptake of HM-PAO between infected and non-infected animals (Fig. 1).…”

contrasting

confidence: 99%

HM-PAO-imaging and herpes encephalitis

Cleator

Lewis

Klapper

et al. 1989

Archives of Virology

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contrasting

confidence: 99%

HM-PAO-imaging and herpes encephalitis

Cleator

Lewis

Klapper

et al. 1989

Archives of Virology

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“…These have demonstrated abnormally increased tracer uptake in the acutely affected temporal lobe [2][3][4][5][6]. However, the PET metabolism pattern of elevated uptake is somewhat different from the SPECT perfusion pattern.…”

Section: Discussionmentioning

confidence: 99%

Sequential Positron Emission Tomographic Evaluations of Brain Metabolism in Acute Herpes Encephalitis

Meyer

Hübner

Raja

et al. 1994

Journal of Neuroimaging

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This first known positron emission tomography report on metabolic changes in acute herpes simplex virus (HSV-1) encephalitis demonstrates focal hypermetabolism in areas of cerebral cortex adjacent to actively inflamed hippocampus acutely infected with HSV-1. When neuropsychiatric symptoms recurred in a previously healthy 61-year-old patient 1 month after recovering from acute HSV-1 encephalitis, repeat positron emission tomography with fluorodeoxyglucose was helpful in ruling out recurrent active infection by showing marked hypometabolism throughout the previously infected temporal lobe.

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“…We ruled out neurological disorders associated with cerebral hypermetabolism on FDG-PET such as high-grade glioma [1,2], herpes simplex encephalitis [3] and seizure [4,5]. There have been two reports in which FDG-PET scan, obtained in the acute stage of LE, demonstrated hypermetabolic foci in the medial temporal lobe [6,7].…”

Section: Discussionmentioning

confidence: 99%