Diagnosis of achalasia by esophageal manometry: The investigation of choice for early presentation

A prospective study of the clinical features, manometric findings, incidence and prevalence of achalasia in Singapore

“…These findings support previous recommendations that manometry should be considered in all patients with persistent dysphagia, even if radiology and endoscopy were normal. 9,12 None of the patients in this study developed oesophageal carcinoma, but this could be due to small patient numbers and a short duration of follow up.…”

“…A group from London recently reported similar findings; 40% of their patients with achalasia had no LOS dysfunction. 12 As part of another protocol, new patients with achalasia attending our institution were being followed up manometrically and/or radiologically for at least 1 year. All of those with an initial diagnosis of achalasia who had a normal LOS function subsequently developed more classical features of achalasia, either manometrically or radiologically (KY Ho, unpubl.…”