Diagnosis of abnormal pregnancy by serum progestins and estrogens in late pregnant mares

Shikichi, Mitsumori; Iwata, Katsuroku; Ito, Katsuhiko; Murase, Harutaka; Sato, Fumio; Korosue, Kenji; Nagata, S.; Nambo, Yasuo

doi:10.1016/j.jevs.2013.10.165

Cited by 6 publications

(5 citation statements)

References 4 publications

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“…Endocrinologically, the progesterone level was higher than normal at 32 weeks of pregnancy and higher than the cutoff value calculated by Shikichi et al [ 19 ] based on abnormal pregnancies at 29 weeks. In addition, the onset of increase was at 26 weeks.…”

contrasting

confidence: 66%

“…Most of these infections are caused by bacteria, and there have been only a few reports on fungal placentitis. Regarding diagnosis of placentitis, the blood concentrations of progestin and estrogen [ 15 , 19 ], the combined thickness of the uterus and placenta (CTUP) [ 18 ], and fetal ultrasonographic indices [ 4 , 16 , 17 ] have been reported as methods of monitoring the fetal and placental conditions. Bacterial placentitis experimental models have been used for research on diagnosis [ 2 , 5 , 8 , 12 ] and treatment [ 3 ].…”

mentioning

confidence: 99%

“…Estradiol stayed within the normal range because the standard range for it was broad due to large individual differences in the normal pregnant mares. Conversely, the estradiol level reached a value below the cutoff value [ 19 ] at 37 weeks, suggesting that the drop in estradiol level heralded abortion.…”

mentioning

confidence: 99%

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A clinical case of equine fungal placentitis with reference to hormone profiles and ultrasonography

Murase

Niwa

Katayama

et al. 2015

JES

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Fungal placentitis is an infectious disease inducing abortion in pregnant mares. In the present report, we describe a field case of abortion caused by fungal placentitis with consecutive examinations. The progesterone level and combined thickness of the uterus and placenta (CTUP) were abnormal before the onset of clinical signs. Additionally, the estradiol level started to change before the appearance of clinical signs. Abnormal serum amyloid A values and an abnormal fetal heart rate were observed after the onset of clinical signs. The present report demonstrates that the progesterone level and CTUP may be adequate as early diagnostic markers of fungal placentitis and bacterial infection. Endocrinological evaluation based on cutoff values or serial measurements were also useful for early diagnosis.

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confidence: 66%

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confidence: 99%

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A clinical case of equine fungal placentitis with reference to hormone profiles and ultrasonography

Murase

Niwa

Katayama

et al. 2015

JES

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“…Although peripheral oestrogens in the mare have been suggested as a possible marker for fetoplacental wellbeing for many years [23,24,34], this is the first report to demonstrate time-dependent changes in oestrogen concentrations subsequent to experimentally-induced, ascending placentitis in mares. Approximately, 99% of the oestradiol 17-b in pregnant mares is present as a sulphoconjugate; however, the remaining 1% is present in the maternal circulation as oestradiol 17b [13].…”

Section: Discussionmentioning

confidence: 90%

Changes in maternal androgens and oestrogens in mares with experimentally‐induced ascending placentitis

Canisso

Ball

Esteller-Vico

et al. 2016

Equine Veterinary Journal

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“…Although the synergistic action of progesterone and estrogen is generally essential for mares, as in most mammals, for maintaining successful pregnancy, estrogen plays a dominant role in the maintenance of uterine elongation when the fetus grows rapidly in late pregnancy [9,10,11,12]. Therefore, monitoring circulating estradiol and progesterone is useful for detecting clinical signs of abortion, stillbirth, and perinatal fetal death during late pregnancy in mares [19,20,21,22]. …”

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confidence: 99%

PATHFAST, a novel chemiluminescent enzyme immunoassay for measuring estradiol in equine whole blood and serum

Toishi

Tsunoda

Kume

et al. 2016

Journal of Reproduction and Development

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A novel chemiluminescent enzyme immunoassay system, PATHFAST, for the measurement of estradiol in horses was evaluated. The concentrations of estradiol in the whole blood and serum of mares were measured using PATHFAST and the estradiol concentrations measured by PATHFAST were compared with those measured by a time-resolved fluoro-immunoassay (FIA). To monitor physiological changes, serum estradiol concentrations in mares were measured using PATHFAST throughout the gestation period. The serum estradiol concentrations correlated highly with those in whole blood samples. The serum concentrations of estradiol measured by PATHFAST also correlated well with FIA. Circulating estradiol increased during mid-gestation and high levels of serum estradiol were maintained in late gestation, followed by an abrupt decline to term. These results demonstrate the utility of PATHFAST in equine clinics as an accurate diagnostic tool for the rapid assay of estradiol within 26 min using unextracted whole blood.

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Diagnosis of abnormal pregnancy by serum progestins and estrogens in late pregnant mares

Cited by 6 publications

References 4 publications

A clinical case of equine fungal placentitis with reference to hormone profiles and ultrasonography

A clinical case of equine fungal placentitis with reference to hormone profiles and ultrasonography

Changes in maternal androgens and oestrogens in mares with experimentally‐induced ascending placentitis

PATHFAST, a novel chemiluminescent enzyme immunoassay for measuring estradiol in equine whole blood and serum

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