Abstract:Pyruvate kinase (PK) deficiency is an important cause of hereditary
non-spherocytic hemolytic anemia caused by a defect in the glycolytic
pathway in red blood cells. PK deficient erythrocytes have impaired ATP
production and resultant difficulty maintaining normal cell integrity
and function, leading to mild to severe anemia due to increased
extravascular hemolysis and splenic destruction. Sequelae of chronic
hemolysis can result in severe and occasionally life-threatening
complications such as hepatobiliary d… Show more
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