Diagnosis by polymerase chain reaction of ocular posttransplant lymphoproliferative disorder after pediatric renal transplantation

Al-Attar, Luma; Berrocal, Audina M.; Warman, Roberto; Dubovy, Sander; Paredes, Ana; Chan, Chi Chao; Davis, Janet L.

doi:10.1016/j.ajo.2003.08.013

Cited by 15 publications

(8 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several other ocular complications may occur following transplantation but were not found in our cohort. PTLD may rarely involve the eyes (16). Unclear ocular findings such as iris nodules should raise a suspicion of PTLD.…”

Section: Discussionmentioning

confidence: 99%

Ocular complications in children and adolescents following renal transplantation

Krause

Snir

Cleper

et al. 2010

Pediatric Transplantation

View full text Add to dashboard Cite

Ocular complications after renal transplantation are common in adults. Nevertheless, data regarding these complications in children are insufficient. The purpose of the present study was to assess ocular morbidity in pediatric renal graft recipients. A retrospective observational study of 71 patients aged 11.2 +/- 5.5 yr was conducted. Mean duration of follow-up was 5.6 +/- 3.5 yr. A total of 16 ocular complications were found in 12 (17%) of the patients. Three patients suffered from more than one complication. Cataract was the most common finding (six patients, 8.4%) followed by swollen disk and hypertensive retinopathy in four patients (5.7%) each and increased intra-ocular pressure in two patients (3%). Mean time interval between transplantation and occurrence of first abnormal ocular finding was 37 +/- 34.5 months. The follow-up time was significantly longer in patients with ophthalmological problems than in those without complications (7.8 yr vs. 5.2 yr, p < 0.02). No statistically significant association was found between the occurrence of ocular complications and the age of the patients at transplantation, donor source, duration of dialysis prior to transplantation, previous corticosteroid therapy or presence of acute rejection episodes. The results of the study point to the importance of regular concurrent ophthalmological follow-up in pediatric renal graft recipients to reduce/prevent ocular morbidity.

show abstract

Section: Discussionmentioning

confidence: 99%

Ocular complications in children and adolescents following renal transplantation

Krause

Snir

Cleper

et al. 2010

Pediatric Transplantation

View full text Add to dashboard Cite

show abstract

“…Although PTLD is one of the most common conditions occurring after solid organ transplantation, ocular PTLD is very rare with only 19 cases reported in the literature (Table I). Bilateral involvement occurred in around half of the cases [1,4,[9][10][11][12][13]15]. The time interval from transplantation to ocular PTLD varied from 3 months to 10 years.…”

Section: Discussionmentioning

confidence: 99%

“…However, around one-third were asymptomatic [6,7,9,10,13]. The most common ocular signs were iris nodules [1,[4][5][6][7][9][10][11][12]14,17] and mutton-fat keratic precipitates [1,[5][6][7][8][9][10][11][12]. Signs of posterior segment involvement included vitritis [3,8,16], subretinal mass [9,12], and optic disc swelling [9,12,13].…”

Section: Discussionmentioning

confidence: 99%

Successful treatment of intraocular post‐transplant lymphoproliferative disorder with intravenous rituximab

Yeung

Loong

et al. 2014

Pediatric Blood & Cancer

View full text Add to dashboard Cite

We reported a rare case of intraocular post-transplant lymphoproliferative disorder (PTLD) arising in a 3-year-old liver transplant recipient who had a prior history of systemic PTLD. The first PTLD entered remission after treatment with intravenous rituximab and withdrawal of immunosuppressants. One year after remission, she presented with granulomatous uveitis and iris nodules in the right eye. Iris biopsy confirmed recurrence of intraocular PTLD, which resolved completely after a second course of intravenous rituximab.

show abstract

“…Ocular involvement is rare in CNS PTLD, with only 17 reported cases (32–45) (Table 2). The majority of these patients were female (76%), children (82%), liver transplant recipients (59%) and on cyclosporine‐based immunosuppression (94%).…”

Section: Discussionmentioning

confidence: 99%

Central nervous system lymphoproliferative disorder in pediatric kidney transplant recipients

Traum

Rodig

Pilichowska

et al. 2006

Pediatric Transplantation

View full text Add to dashboard Cite

Post-transplant lymphoproliferative disorder (PTLD) is a complication of transplantation resulting from impaired immune surveillance because of pharmacologic immunosuppression. We present two cases of central nervous system (CNS) PTLD in children on calcineurin-inhibitor free immunosuppression with dramatically different presentations and outcomes. One patient had brain and spinal cord lymphoma with a rapid and fatal course. The other patient had brain and ocular PTLD that responded to multimodal therapy with reduction of immunosuppression, high-dose steroids, and rituximab given in a dose-escalation protocol. This protocol may have enhanced the penetration of rituximab into the CNS. We review the literature on CNS and ocular PTLD and elaborate on the treatments available for both diseases.

show abstract

Diagnosis by polymerase chain reaction of ocular posttransplant lymphoproliferative disorder after pediatric renal transplantation

Cited by 15 publications

References 5 publications

Ocular complications in children and adolescents following renal transplantation

Ocular complications in children and adolescents following renal transplantation

Successful treatment of intraocular post‐transplant lymphoproliferative disorder with intravenous rituximab

Central nervous system lymphoproliferative disorder in pediatric kidney transplant recipients

Contact Info

Product

Resources

About